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Diagnostics
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Diagnosis and Assessment of Spondyloarthritis
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Diagnosis and Assessment of Spondyloarthritis

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 13175

Special Issue Editors

Prof. Eduardo Collantes-Estevez

E-Mail Website
Guest Editor
Department of Rheumatology Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC) and University of Cordoba, Cordoba, Spain
Interests: bone; rheumatoid arthritis; arthritis; spondyloarthritis
Dr. Clementina López Medina

E-Mail Website
Guest Editor
1. Rheumatology Department, University Hospital Reina Sofía, 14004 Córdoba, Spain
2. Maimonides Institute of Biomedical Research From Córdoba, 14004 Córdoba, Spain
3. Department of Medical and Surgical Sciencies, University of Córdoba, 14004 Córdoba, Spain
Interests: spondyloarthritis; rheumatoid arthritis; psoriatic arthritis; back pain; imaging; epidemiology; machine learning; patient reported outcomes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Spondyloarthritis (SpA) represents a heterogeneous group of rheumatic inflammatory entities involving the axial skeleton, enthesis, and peripheral joints and may occur together with extra-articular manifestations, such as psoriasis, inflammatory bowel disease, and uveitis.

Important advances in the understanding of SpA have been made in the area of classification criteria, which have significantly improved the approach to these diseases and the better identification of patients in early stages of the disease. However, the early identification of these patients and the shortening of the diagnosis delay remain a challenge. In addition, the classification criteria cannot be used as diagnosis criteria; thus, new diagnosis tools are needed.

Due to the chronic course of the disease, reliable tools are needed to better assess function, mobility, disease activity, structural damage and treatment response.

The aim of this Special issue is to update the clinical and technological applications that can be useful in the diagnosis and assessment of SpA patients.

Prof. Eduardo Collantes-Estevez
Dr. Clementina López Medina
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Research

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11 pages, 715 KiB  
Article
The Prevalence of MRI-Defined Sacroiliitis and Classification of Spondyloarthritis in Patients with Acute Anterior Uveitis: A Longitudinal Single-Centre Cohort Study
by Kristyna Bubova, Lenka Hasikova, Katerina Mintalova, Monika Gregova, Petr Kasalicky, Aneta Klimova, Michaela Brichova, Petra Svozilkova, Jarmila Heissigerova, Jiri Vencovsky, Karel Pavelka and Ladislav Senolt
Diagnostics 2022, 12(1), 161; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics12010161 - 11 Jan 2022
Cited by 2 | Viewed by 1743
Abstract
Background: Acute anterior uveitis (AAU) is a relatively common extra-musculoskeletal manifestation of axial spondyloarthritis (axSpA); however, data on the prevalence of active sacroiliitis in patients with AAU are limited. Methods: 102 patients with AAU and 39 healthy subjects (HS) underwent clinical assessment and [...] Read more.
Background: Acute anterior uveitis (AAU) is a relatively common extra-musculoskeletal manifestation of axial spondyloarthritis (axSpA); however, data on the prevalence of active sacroiliitis in patients with AAU are limited. Methods: 102 patients with AAU and 39 healthy subjects (HS) underwent clinical assessment and sacroiliac joint MRI. Patients with absence of active sacroiliitis were reassessed after two years. International Spondyloarthritis Society (ASAS) classification criteria for axSpA (regardless of patient’s age) and expert opinion for definitive diagnosis of axSpA were applied. Results: Although chronic back pain was equally present in both groups, bone marrow edema (BME) in SIJ and BME highly suggestive of axSpA was found in 52 (51%) and in 33 (32%) patients with AAU compared with 11 (28%) and none in HS, respectively. Out of all AAU patients, 41 (40%) patients fulfilled the ASAS classification criteria for axSpA, and 29 (28%) patients were considered highly suggestive of axSpA based on clinical features. Two out of the 55 sacroiliitis-negative patients developed active sacroiliitis at the two-year follow-up. Conclusions: One-third of patients with AAU had active inflammation on SIJ MRI and clinical diagnosis of axSpA. Therefore, patients with AAU, especially those with chronic back pain, should be referred to a rheumatologist, and the examination should be repeated if a new feature of SpA appears. Full article
(This article belongs to the Special Issue Diagnosis and Assessment of Spondyloarthritis)
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12 pages, 785 KiB  
Article
Mechanical Properties of Lumbar and Cervical Paravertebral Muscles in Patients with Axial Spondyloarthritis: A Case-Control Study
by Juan L. Garrido-Castro, I. Concepción Aranda-Valera, José Peña-Amaro, Alfonso Martínez-Galisteo, Cristina González-Navas, Daiana P. Rodrigues-de-Souza, Sandra Alcaraz-Clariana, Lourdes García-Luque, Iago R. Martínez Sánchez, Clementina López-Medina, Eduardo Collantes-Estévez and Francisco Alburquerque-Sendín
Diagnostics 2021, 11(9), 1662; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics11091662 - 10 Sep 2021
Cited by 9 | Viewed by 1997
Abstract
Background: Axial spondyloarthritis (axSpA) affects spinal muscles, due to inflammation and structural damage. The mechanical properties of the muscles, such as tone or stiffness, could be altered in axSpA. The aim of this work is to analyze the mechanical properties of cervical and [...] Read more.
Background: Axial spondyloarthritis (axSpA) affects spinal muscles, due to inflammation and structural damage. The mechanical properties of the muscles, such as tone or stiffness, could be altered in axSpA. The aim of this work is to analyze the mechanical properties of cervical and lumbar spine muscles in axSpA patients and their relationship with metrology measures, function, disease activity, structural damage and quality of life. Methods: axSpA patients and age/gender/BMI matched healthy controls were recruited. The muscle mechanical properties (MMPs), such as tone or frequency, stiffness, decrement (linear elastic properties), relaxation and creep (viscoelastic properties), of cervical (semispinalis capitis) and lumbar (erector spinae) muscles were bilaterally measured at rest using myotonometry. Additionally, conventional metrology, BASMI (metrology index), BASDAI (disease activity index), mSASSS (radiological structural damage index) and SF-12 (health-related quality of life questionnaire) were used in the axSpA group. Between-groups comparison, intra-group correlations and multivariable regression analyses were performed to achieve the study aims. Results: Thirty-four axSpA patients (mean age: 46.21 ± 8.53 y) and 34 healthy volunteers (mean age: 43.97 ± 8.49 y) were recruited. Both in cervical and lumbar spine, linear elastic parameters were significantly higher in axSpA patients in comparison with controls, while viscoelastic parameters were significantly lower. Lumbar muscle frequency, stiffness, relaxation, creep and cervical muscle elasticity were fair to strongly correlated (|0.346| < r < |0.774|) with age, functional status, activity of disease, structural damage and quality of life in axSpA patients. Furthermore, moderate to good fitted multivariate models (0.328 < R2 < 0.697) were obtained combining age, conventional metrology, activity of the disease and function for the estimation of cervical and lumbar MMPs. Conclusion: Mechanical properties of spinal muscles of axSpA patients differ from controls. Lumbar and cervical muscles exhibit greater linear elastic properties and lower viscoelastic properties, which are related with age, clinical and psychophysiological features of axSpA. Full article
(This article belongs to the Special Issue Diagnosis and Assessment of Spondyloarthritis)
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Review

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10 pages, 4062 KiB  
Review
Main Diagnostic Pitfalls in Reading the Sacroiliac Joints on MRI
by Sammy Badr, Thibaut Jacques, Guillaume Lefebvre, Youssef Boulil, Ralph Abou Diwan and Anne Cotten
Diagnostics 2021, 11(11), 2001; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics11112001 - 28 Oct 2021
Cited by 7 | Viewed by 8550
Abstract
Magnetic resonance imaging of the sacroiliac joints is now frequently performed to help identify patients with early axial spondyloarthritis. However, differential diagnoses exist and should be recognized. The aim of this article is to review the most frequent differential diagnoses that may mimic [...] Read more.
Magnetic resonance imaging of the sacroiliac joints is now frequently performed to help identify patients with early axial spondyloarthritis. However, differential diagnoses exist and should be recognized. The aim of this article is to review the most frequent differential diagnoses that may mimic inflammatory sacroiliitis in clinical practice. Full article
(This article belongs to the Special Issue Diagnosis and Assessment of Spondyloarthritis)
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