Dear Colleagues,

In parallel to the surge of studies in the field of epigenetics, dozens of epitranscriptional RNA modifications were identified in the last decades. Research in the epitranscriptome field has benefited from the recent development of methods to better quantify these marks and profile them at the genome level. Yet, despite a number of studies have confirmed the prominent role of some of these marks in shaping the fate of marked RNAs, we are only at the beginning of deciphering the effects of these modifications. Multiple effectors were identified that contribute to installing, removing, and reading these marks. However, the detailed activity of individual effectors and their joint contribution to the establishment of specific epitranscriptional patterns are yet to be deciphered. As the field progresses, novel methods are awaited for the specific, quantitative, and high-resolution profiling of these marks. Eventually, these maps will start revealing the functional role of individual modifications in physiological and disease conditions and whether the ensemble of modifications decorating various transcript types defines a new epitranscriptional code.

In this Special Issue, we will consider outstanding reviews, research, or method manuscripts on the following topics:

• Experimental methods to profile RNA modifications
• Computational methods for the analysis of epitranscriptional data
• Insights on the functional role of epitranscriptional marks and their effectors
• Prevalence and functional role of epitranscriptional marks in diseases
• The crosstalk between epitranscriptional marks
• The crosstalk between the epitranscriptome and the epigenome

Dr. Mattia Pelizzola
Dr. Silvo Conticello
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Epigenomes is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.