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Dear Colleagues,

Our current ability to detect neurodegenerative diseases early and manage them is limited. The insidious processes underlying these conditions are only partly understood, while the treatments used have limited efficacies. Current research aims to understand the mechanisms underlying the progressive axonal loss in various neurologic conditions and seeks ways to properly monitor, quantify, and treat their relevant clinical implications.

This Special Issue of Healthcare seeks commentaries, original research, short reports, and reviews focusing on challenges in detecting, monitoring, and treating neurodegenerative diseases. This Special Issue aims to provide information about advances in the research of various primarily neurodegenerative conditions such as dementia, Parkinson’s Disease, motor neurone disease, and diseases with evident neurodegenerative components such as multiple sclerosis.

Dr. Christos Bakirtzis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Healthcare is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Related Special Issue

Published Papers (1 paper)

Review

14 pages, 3077 KiB

Open AccessReview

The Time Trajectory of Choroid Plexus Enlargement in Multiple Sclerosis

by Athina Andravizou, Sotiria Stavropoulou De Lorenzo, Evangelia Kesidou, Iliana Michailidou, Dimitrios Parissis, Marina-Kleopatra Boziki, Polyxeni Stamati, Christos Bakirtzis and Nikolaos Grigoriadis

Healthcare 2024, 12(7), 768; https://0-doi-org.brum.beds.ac.uk/10.3390/healthcare12070768 - 01 Apr 2024

Viewed by 696

Abstract

Choroid plexus (CP) can be seen as a watchtower of the central nervous system (CNS) that actively regulates CNS homeostasis. A growing body of literature suggests that CP alterations are involved in the pathogenesis of multiple sclerosis (MS) but the underlying mechanisms remain elusive. CPs are enlarged and inflamed in relapsing-remitting (RRMS) but also in clinically isolated syndrome (CIS) and radiologically isolated syndrome (RIS) stages, far beyond MS diagnosis. Increases in the choroid plexus/total intracranial volume (CP/TIV) ratio have been robustly associated with increased lesion load, higher translocator protein (TSPO) uptake in normal-appearing white matter (NAWM) and thalami, as well as with higher annual relapse rate and disability progression in highly active RRMS individuals, but not in progressive MS. The CP/TIV ratio has only slightly been correlated with magnetic resonance imaging (MRI) findings (cortical or whole brain atrophy) and clinical outcomes (EDSS score) in progressive MS. Therefore, we suggest that plexus volumetric assessments should be mainly applied to the early disease stages of MS, whereas it should be taken into consideration with caution in progressive MS. In this review, we attempt to clarify the pathological significance of the temporal CP volume (CPV) changes in MS and highlight the pitfalls and limitations of CP volumetric analysis. Full article

(This article belongs to the Special Issue Prevention, Intervention and Care of Neurodegenerative Diseases: Second Edition)

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