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New Insight into Cardiovascular Disease in Elderly People
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New Insight into Cardiovascular Disease in Elderly People

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Cardiovascular Clinical Research".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 3325

Special Issue Editors

Dr. Lorenzo Fácila

E-Mail Website
Guest Editor
Cardiology Department, General University Hospital of Valencia, 46014 Valencia, Spain
Interests: Cardiovascular disease; atrial fibrillation; anticoagulation; antiplatelet; ACS; CCS
Dr. Clara Bonanad

E-Mail Website
Guest Editor
Cardiology Department, Clinic University Hospital of Valencia, 46010 Valencia, Spain
Interests: cardiovascular disease; atrial fibrillation; frailty; elderly; inflammation; residual risk; anticoagulation; antiplatelet; ACS; CCS
Special Issues, Collections and Topics in MDPI journals
Dr. Albert Ariza-Sole

E-Mail Website
Guest Editor
1. Cardiology Department, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
2. Bioheart Grup de Malalties Cardiovasculars, Institut d’Investigació Biomèdica de Bellvitge—IDIBELL, L’Hospitalet de Llobregat, 08908 Barcelona, Spain
Interests: Cardiovascular disease; atrial fibrillation; frailty; elderly; inflammation; residual risk; anticoagulation; antiplatelet; ACS; CCS
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiovascular diseases are frequent among elderly patients. It is estimated that 70% of the population over 70 will develop cardiovascular diseases. People older than 65 are more likely to suffer acute coronary syndrome, experience a stroke, or develop coronary artery disease and heart failure. Heart disease is also the leading cause of mortality, disability, and deterioration of the quality of life of millions of older adults. The geriatric population has grown worldwide in recent decades because life expectancy has increased significantly. However, the aged population is underrepresented in clinical trials, and current clinical practice guidelines do not include specific recommendations. Elderly patients with cardiovascular disease present characteristics that may differ from the general population. They are also a heterogeneous group that ranges from robust and independent individuals to those who may experience additional complications such as polypharmacy, frailty, comorbidities, or inflammation.

Thus, in this Special Issue, we welcome contributions focused on various domains related to cardiovascular disease in the elderly, in order to improve the management of elderly patients with acute coronary syndrome and other cardiovascular diseases.

Dr. Lorenzo Fácila
Dr. Clara Bonanad
Dr. Albert Ariza-Sole
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular disease
  • atrial fibrillation
  • frailty
  • elderly
  • inflammation
  • residual risk
  • anticoagulation
  • antiplatelet
  • ACS
  • CCS

Published Papers (2 papers)

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Research

11 pages, 1595 KiB  
Article
Weight Change and Risk of Atherosclerosis Measured by Carotid Intima–Media Thickness (cIMT) from a Prospective Cohort—Analysis of the First-Wave Follow-Up Data of the Canadian Longitudinal Study on Aging (CLSA)
by Jian Liu, Newman Siu Kwan Sze, Miya Narushima and Deborah O’Leary
J. Cardiovasc. Dev. Dis. 2023, 10(10), 435; https://0-doi-org.brum.beds.ac.uk/10.3390/jcdd10100435 - 19 Oct 2023
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Abstract
To explore impact of weight change (WC) on risk of atherosclerosis measured by cIMT, 20,700 participants from the CLSA follow-up were included in analysis. WC was defined as the difference of weight measured at follow-up and baseline, then quartered into four groups (Q1–Q4). [...] Read more.
To explore impact of weight change (WC) on risk of atherosclerosis measured by cIMT, 20,700 participants from the CLSA follow-up were included in analysis. WC was defined as the difference of weight measured at follow-up and baseline, then quartered into four groups (Q1–Q4). cIMT > 1.0 mm was defined as high risk for atherosclerosis. Adjusted odds ratio (OR (95% CI)) from logistic regression models were used to evaluate the association between WC and risk of atherosclerosis. At follow-up, participants had gained 0.118 kg weight, on average, and 16.4% of them were at high risk for atherosclerosis. The mean levels of cIMT were comparable between participants from Q1 to Q4. Compared to Q2 (reference), the ORs (95% CI) were 1.00 (0.86, 1.15), 1.19 (1.03,1.38), and 1.25 (1.08,1.45) for Q1, Q3, and Q4, respectively. A similar pattern was observed when analyses were conducted for ages < 65 vs. 65+ separately, but it was weaker for those aged 65+. Results from the jointed distribution analyses indicated that moderate weight loss might increase risk for atherosclerosis among participants with obese BMI at baseline, but not for those with cardiovascular event status at baseline. Weight gain, however, would increase risk for atherosclerosis regardless of cardiovascular event status, or overweight/obese BMI at baseline. Full article
(This article belongs to the Special Issue New Insight into Cardiovascular Disease in Elderly People)
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14 pages, 516 KiB  
Article
Educational Intervention Effects on Depression and Anxiety in Patients after Myocardial Infarction: A Randomized Controlled Trial
by Lazzat M. Zhamaliyeva, Damira G. Zhamankulova, Nurgul A. Abenova and Gulbakit K. Koshmaganbetova
J. Cardiovasc. Dev. Dis. 2023, 10(7), 267; https://0-doi-org.brum.beds.ac.uk/10.3390/jcdd10070267 - 22 Jun 2023
Viewed by 1516
Abstract
Depression and anxiety in cardiovascular disease worsen the prognosis of patients. Treatments for these disorders often provide limited improvement. The present study aimed to test, for the first time, the impact of educational technology on anxiety and depressive symptoms in patients participating in [...] Read more.
Depression and anxiety in cardiovascular disease worsen the prognosis of patients. Treatments for these disorders often provide limited improvement. The present study aimed to test, for the first time, the impact of educational technology on anxiety and depressive symptoms in patients participating in a cardiac rehabilitation program. A 12-month randomized controlled trial was conducted, in which 207 patients were randomly assigned to either the experimental (n = 76) or control (n = 69) groups. The intervention involved a structured patient education program provided by medical students who had undergone specially designed training in cardiac rehabilitation. The primary outcomes were death, hospitalization, heart failure, and recurrent myocardial infarction. The study also assessed anxiety and depression. A year later, the experimental group showed a statistically significant decrease in anxiety and depression on the HADS scale, with reductions of 2.0 and 1.9 points, respectively (p < 0.05). The control group showed reductions of 1.5 and 1.2 points (p < 0.05). The difference in the Hamilton Rating Scale for Depression between the groups at 12 months was −1.29 in favor of the main group (95% CI, −0.7 to −1.88), and the standardized mean difference was 0.36 (95% CI, 0.03 to 0.69). No treatment-related adverse events were observed. The results suggest that educational interventions can have a positive impact on mental health. The study’s strengths include a structured intervention, randomization, and long-term follow-up. The limitations include the lack of blinding of study participants and a relatively small sample size. Full article
(This article belongs to the Special Issue New Insight into Cardiovascular Disease in Elderly People)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Epigenetics, immunosenescence and iron deficiency in ACS: an unknown enemy
Authors: Andrea Arroyo-Álvarez; Guillermo Barreres; Carles Muñoz-Alfonso; Daniela Maidana; Clara Bonanad-Lozano
Affiliation: Servicio de Cardiología, Hospital Clínico Universitario de Valencia, Valencia, España
Abstract: In 2050, more than 30% of the world's population will become older adults, 70% of whom will develop cardiovascular disease. Therefore, improving these patients' diagnostic, prognostic, and therapeutic approaches is relevant and explains the emerging interest in geriatric cardiology. Iron deficiency reaches a prevalence of about 60% in these patients. Iron deficiency affects the prognostic and quality of life of those patients. There are factors involved in aging, including low-grade chronic degradation, chronic inflammation, oxidative stress, the accumulation of senescent cells, and epigenetic alterations. Accelerated biological age based on epigenetic markers has been related to the progression of atherosclerosis, worse prognosis of cardiovascular disease, and a proinflammatory profile. This chronic inflammation increases with age and has also been associated with the progression of atherosclerosis, high cardiovascular risk, and poor prognosis of older cardiac patients. Thus, the concept of inflammaging appeared. Furthermore, inflammation also disrupts iron metabolism, as inflammatory cytokines promote hepcidin expression, increasing iron retention within storage cells, which can lead to functional iron deficiency.

Title: Surgical Treatment of Acute Type A Aortic Dissection in Elderly Patients
Authors: Leonard Pitts
Affiliation: 1. Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany; 2. Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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