Diagnosis and Management Strategies for Dry Eye Disease

Dear Colleagues,

In July 2020, the first volume of the Special Issue “Pathogenesis of the Homeostatic Failure of Ocular Surface as Morpho-Functional Unit” was launched (https://0-www-mdpi-com.brum.beds.ac.uk/journal/jcm/special_issues/ocular_surface). We received many excellent papers on the topic of the ocular surface and its diseases. Now, we would like to launch the new volume on this topic, focusing on evaporative alterations in tears.

The ocular surface system interacts with, reacts with, and adapts to daily continuous insults, trauma, and stimuli caused by direct exposure to the atmosphere and environment. Several tissue and para-inflammatory mechanisms interact to guarantee such functions, maintaining a healthy homeostatic equilibrium. Evaporation seriously affects this homeostasis, thereby becoming a critical trigger in the pathogenesis of the vicious cycle of dry eye disease (DED). Tear film lipid composition, distribution, spreading, and efficiency are crucial factors in controlling water evaporation, and are involved in the onset of the hyperosmolar and inflammatory cascades of DED. The structure of tear film lipids, and subsequently the tear film, has a considerable impact on the properties and main functions of tears, leading to a peculiar clinical picture and specific management.

The main aim of this Special Issue is to investigate the evaporative changes in dry eye disease, which affect 80% of patients. It will focus on their causes, biochemical changes, diagnostic methods, and innovative treatments.

Dr. Antonio Di Zazzo
Guest Editor

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• dry eye disease
• ocular surface diseases
• ocular surface diabetic disease