Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.5
3.3
Journals
J. Compos. Sci.
Special Issues
Bio-Abio Nanocomposites for Bio-Applications
share announcement

Bio-Abio Nanocomposites for Bio-Applications

A special issue of Journal of Composites Science (ISSN 2504-477X). This special issue belongs to the section "Biocomposites".

Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 11709

Special Issue Editors

Prof. Dr. Jeong-Hwan Kim

E-Mail Website
Guest Editor
Faculty of Cardiovascular Research Institute, Graduate Scool of Medicine, Yokohama City University, Yokohama, Japan
Interests: surface and colloid chemistry; synthesis of hybrid nanocomposites; nano-pharmaceutics/theranostics; drug delivery systems; smart nanocomposites; bio-inspired nanosheet composites
Special Issues, Collections and Topics in MDPI journals
Dr. Maria Benelmekki

E-Mail
Guest Editor
Nanomaterials Lab., College of Engineering, Swansea University, Swansea, UK
Interests: surface and interfaces; biomagnetic separation; hybrid nanomaterials; advanced characterization; spectroscopy; electron microscopy; nanostructures

Special Issue Information

Dear Colleagues,

The unseen exclusive properties of nanocomposites have fascinated researchers, especially in bio-applications due to their combined/synergistic structural features with diverse components derived from nature and synthetic systems. The key challenge is a controlled synthesis of interracially/spatially well-defined heterogeneous structures, biocompatible functionalization, and stable processing to be acceptable for translational/clinical stages. Thus, harmonizing the structure–property–processing of nanocomposites of divergent (bio-abio) materials is crucial for their future bio-applications as innovative hybrid material systems.

The scope of this Special Issue covers state-of-the-art synthesis and functions of heterogeneous nanocomposite materials to offer an insight into this new family of composites with the incorporation of dissimilar bio/abio-building blocks with interest in diverse bio-applications, including, in particular, pharmaceutics, biodiagnostics, therapeutics, bioimaging, or biosensing. Contributions should be primarily related to the orchestrated chemical design of biocompatible hybrid nanocomposite structures, such as particles, assemblies, dispersions, surface/interface; their unique properties by mixing/coupling their components, e.g., biomolecules, polymers, biodegradable materials, green/natural products, and biosafe inorganic minerals/materials; and the functionalization of bio-nano-interfaces.

Dr. Jeong-Hwan Kim
Dr. Maria Benelmekki
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Composites Science is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanocomposites
  • Nanoparticles
  • Heterogeneous materials interface
  • Surface functionalization
  • Aqueous dispersion
  • Material properties
  • Biodiagnostics/therapeutics

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review, Other

12 pages, 3059 KiB  
Article
Methotrexate-Transferrin-Functionalized Fe(Salen)-Polypyrrole Nanocomposites for Targeted Photo-/Magneto-Thermal Cancer Treatments
by Jeong-Hwan Kim, Masanari Umemura, Haruki Eguchi and Yoshihiro Ishikawa
J. Compos. Sci. 2022, 6(5), 136; https://0-doi-org.brum.beds.ac.uk/10.3390/jcs6050136 - 08 May 2022
Cited by 7 | Viewed by 2062
Abstract
Designing multi-modal topical drug delivery nanocarriers using nano-hybrid particles has received significant interest in targeted cancer therapy. In this study, magnetic Fe(salen)-conducting copolymer nanocomposites based on our previous iron salt-free synthesis method are surface-functionalized with methotrexate and transferrin proteins. The nano-hybrids show near-infrared-/magnetic [...] Read more.
Designing multi-modal topical drug delivery nanocarriers using nano-hybrid particles has received significant interest in targeted cancer therapy. In this study, magnetic Fe(salen)-conducting copolymer nanocomposites based on our previous iron salt-free synthesis method are surface-functionalized with methotrexate and transferrin proteins. The nano-hybrids show near-infrared-/magnetic field-responsive hyperthermal activity in vitro, which can be extraordinarily useful in magnetically guidable local cancer targeting as a versatile multi-modal therapeutic drug delivery system. Full article
(This article belongs to the Special Issue Bio-Abio Nanocomposites for Bio-Applications)
►▼ Show Figures

Figure 1

13 pages, 5258 KiB  
Article
Aligned Collagen-CNT Nanofibrils and the Modulation Effect on Ovarian Cancer Cells
by Wen Li, Naiwei Chi, Elwin D. Clutter, Bofan Zhu and Rong R. Wang
J. Compos. Sci. 2021, 5(6), 148; https://0-doi-org.brum.beds.ac.uk/10.3390/jcs5060148 - 02 Jun 2021
Cited by 5 | Viewed by 2455
Abstract
Fibrillar collagen is a one-dimensional biopolymer and is the most abundant structural protein in the extracellular matrix (ECM) of connective tissues. Due to the unique properties of carbon nanotubes (CNTs), considerable attention has been given to the application of CNTs in developing biocomposite [...] Read more.
Fibrillar collagen is a one-dimensional biopolymer and is the most abundant structural protein in the extracellular matrix (ECM) of connective tissues. Due to the unique properties of carbon nanotubes (CNTs), considerable attention has been given to the application of CNTs in developing biocomposite materials for tissue engineering and drug delivery. When introduced to tissues, CNTs inevitably interact and integrate with collagen and impose a discernible effect on cells in the vicinity. The positive effect of the collagen-CNT (COL-CNT) matrix in tissue regeneration and the cytotoxicity of free CNTs have been investigated extensively. In this study, we aimed to examine the effect of COL-CNT on mediating the interaction between the matrix and SKOV3 ovarian cancer cells. We generated unidirectionally aligned collagen and COL-CNT nanofibrils, mimicking the structure and dimension of collagen fibrils in native tissues. AFM analysis revealed that the one-dimensional structure, high stiffness, and low adhesion of COL-CNT greatly facilitated the polarization of SKOV3 cells by regulating the β-1 integrin-mediated cell–matrix interaction, cytoskeleton rearrangement, and cell migration. Protein and gene level analyses implied that both collagen and COL-CNT matrices induced the epithelial–mesenchymal transition (EMT), and the COL-CNT matrix prompted a higher level of cell transformation. However, the induced cells expressed CD44 at a reduced level and MMP2 at an increased level, and they were responsive to the chemotherapy drug gemcitabine. The results suggested that the COL-CNT matrix induced the transdifferentiation of the epithelial cancer cells to mature, less aggressive, and less potent cells, which are inapt for tumor metastasis and chemoresistance. Thus, the presence of CNT in a collagen matrix is unlikely to cause an adverse effect on cancer patients if a controlled dose of CNT is used for drug delivery or tissue regeneration. Full article
(This article belongs to the Special Issue Bio-Abio Nanocomposites for Bio-Applications)
►▼ Show Figures

Figure 1

Review

Jump to: Research, Other

21 pages, 5809 KiB  
Review
Recent Advances in Porous 3D Cellulose Aerogels for Tissue Engineering Applications: A Review
by Ali Mirtaghavi, Jikui Luo and Rajendran Muthuraj
J. Compos. Sci. 2020, 4(4), 152; https://0-doi-org.brum.beds.ac.uk/10.3390/jcs4040152 - 19 Oct 2020
Cited by 29 | Viewed by 4617
Abstract
Current approaches in developing porous 3D scaffolds face various challenges, such as failure of mimicking extracellular matrix (ECM) native building blocks, non-sustainable scaffold fabrication techniques, and lack of functionality. Polysaccharides and proteins are sustainable, inexpensive, biodegradable, and biocompatible, with structural similarities to the [...] Read more.
Current approaches in developing porous 3D scaffolds face various challenges, such as failure of mimicking extracellular matrix (ECM) native building blocks, non-sustainable scaffold fabrication techniques, and lack of functionality. Polysaccharides and proteins are sustainable, inexpensive, biodegradable, and biocompatible, with structural similarities to the ECM. As a result, 3D-structured cellulose (e.g., cellulose nanofibrils, nanocrystals and bacterial nanocellulose)-based aerogels with high porosity and interconnected pores are ideal materials for biomedical applications. Such 3D scaffolds can be prepared using a green, scalable, and cost-effective freeze-drying technique. The physicochemical, mechanical, and biological characteristics of the cellulose can be improved by incorporation of proteins and other polysaccharides. This review will focus on recent developments related to the cellulose-based 3D aerogels prepared by sustainable freeze-drying methods for tissue engineering applications. We will also provide an overview of the scaffold development criteria; parameters that influenced the aerogel production by freeze-drying; and in vitro and in vivo studies of the cellulose-based porous 3D aerogel scaffolds. These efforts could potentially help to expand the role of cellulose-based 3D scaffolds as next-generation biomaterials. Full article
(This article belongs to the Special Issue Bio-Abio Nanocomposites for Bio-Applications)
►▼ Show Figures

Figure 1

Other

Jump to: Research, Review

8 pages, 2333 KiB  
Perspective
The Biomimetic Evolution of Composite Materials: From Straw Bricks to Engineering Structures and Nanocomposites
by Gad Marom
J. Compos. Sci. 2021, 5(5), 123; https://0-doi-org.brum.beds.ac.uk/10.3390/jcs5050123 - 07 May 2021
Cited by 3 | Viewed by 1936
Abstract
Advanced polymer-based composite materials have revolutionized the structural material arena since their appearance some 60 years ago. Yet, despite their relatively short existence, they seem to be taken for granted as if they have always been there. One of the reasons for this [...] Read more.
Advanced polymer-based composite materials have revolutionized the structural material arena since their appearance some 60 years ago. Yet, despite their relatively short existence, they seem to be taken for granted as if they have always been there. One of the reasons for this state of affairs is that composite materials of various types have accompanied human history for thousands years, and their emergence in the modern era could be considered a natural evolutionary process. Nevertheless, the continuous line that leads from early days of composites in human history to current structural materials has exhibited a number of notable steps, each generating an abrupt advance toward the contemporary new science of composite materials. In this paper, I review and discuss the history of composites with emphasis on the main steps of their development. Full article
(This article belongs to the Special Issue Bio-Abio Nanocomposites for Bio-Applications)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop