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Medical Mycology Research in Israel
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Medical Mycology Research in Israel

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".

Deadline for manuscript submissions: 10 November 2024 | Viewed by 1222

Special Issue Editor

Dr. Maya Korem

E-Mail Website
Guest Editor
Department of Clinical Microbiology and Infectious Diseases, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112001, Israel
Interests: Candida; Cryptococcus; antifungal susceptibility; fungal resistance; diagnostic methods

Special Issue Information

Dear Colleagues,

Fungal diseases are often caused by fungi that are common in the environment and their spectrum of severity ranges from mild superficial infections to invasive and life-threatening diseases. Fungal pathogens are a major threat to public health, especially in severely ill patients and immunocompromised hosts. The incidence and geographic range of fungal diseases are expanding worldwide and fungi are becoming increasingly resistant to antifungals. According to surveillance data in Israel, candidemia and invasive aspergillosis are the most frequent serious fungal diseases with significant morbidity and mortality.

This Special Issue aims to present new data on fungal infections in Israel (e.g., epidemiology and clinical data, diagnostic methods, antifungal susceptibility, and resistance mechanisms) and provide insight into current mycology research in Israel. Original studies, case studies, and reviews are welcome.

Dr. Maya Korem
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fungal infection
  • Candida
  • Aspergillus
  • antifungal susceptibility
  • dematiaceous molds

Published Papers (1 paper)

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10 pages, 444 KiB  
Brief Report
A 14-Year Cohort of Candidemia in the Pediatric Population in a Tertiary Center in Jerusalem: Clinical Characteristics, Antifungal Susceptibility, and Risk Factors for Mortality
by Maya Korem, Asher Taragin, Danna Dror, Violeta Temper and Dina Averbuch
J. Fungi 2023, 9(12), 1171; https://0-doi-org.brum.beds.ac.uk/10.3390/jof9121171 - 06 Dec 2023
Viewed by 1006
Abstract
Candida spp. can cause bloodstream infection and is associated with significant mortality. The proportion of fluconazole-resistant Candida non-albicans has increased over the years, and empirical fluconazole maybe inappropriate. In this retrospective study, we analyzed clinical characteristics, antifungal resistance patterns, and mortality in [...] Read more.
Candida spp. can cause bloodstream infection and is associated with significant mortality. The proportion of fluconazole-resistant Candida non-albicans has increased over the years, and empirical fluconazole maybe inappropriate. In this retrospective study, we analyzed clinical characteristics, antifungal resistance patterns, and mortality in children with candidemia treated at a tertiary medical center in Jerusalem between 2009 and 2022. A total of 122 children developed 127 candidemia episodes with 132 Candida isolates. Half the episodes occurred in immunocompromised children. Septic shock was present in 27 (21.3%). Candida non-albicans was responsible for 71/132 (56.5%) episodes; 16/132 (12.1%) of isolates were fluconazole-resistant. The rate of Candida non-albicans was significantly higher in fluconazole-resistant episodes (90 vs. 50.5%, p = 0.02). Prolonged severe neutropenia and previous fluconazole exposure were more frequent in fluconazole-resistant episodes. Thirty-day mortality was 25 (19.7%). Greater mortality, as shown by multivariate analysis, was associated with candidemia contracted in the pediatric intensive care unit (PICU), previous use of azoles or carbapenems, and in the presence of shock. In conclusion, mortality rates in our study were higher than those previously reported. In suspected infection associated with factors which we found to increase the probability of mortality—PICU admission, shock, and earlier azole or carbapenems exposure—empirical antifungals should be considered. Full article
(This article belongs to the Special Issue Medical Mycology Research in Israel)
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