Genetics and Epigenetic Mechanisms of the Neurovascular Unit
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Genetics and Genomics".
Deadline for manuscript submissions: closed (15 December 2021) | Viewed by 4714
Special Issue Editors
Interests: genetics; molecular genetics; molecular biology; genomics; transcriptomics; next generation sequencing analysis; population genetics; gene expression regulation; neuroscience; characterization of molecular mechanisms involved in the pathogenesis of genetic rare mendelian diseases; cerebral cavernous malformations; brain arteriovenous malformations; retinitis pigmentosa; Genetics of metabolic diseases
Interests: molecular genetics and predictive medicine; molecular biology; genetics; DNA sequencing; population genetics; SNPs; genetic and molecular mechanisms involved in the pathogenesis of cerebrovascular diseases; cerebral cavernous malformations; identification of candidate genes and causative variants in different forms of retinitis pigmentosa; molecular genetic features and genotype–phenotype correlations in trimethylaminuria
Special Issues, Collections and Topics in MDPI journals
Interests: rare genetic diseases such as cerebral cavernous malformations (CCMs); trimethylaminuria (TMAU) inherited retinal dystrophies (IRDs); retinitis pigmentosa (RP)
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The Neurovascular Unit (NVU) is a concept that was formulated in 2001, during the Stroke Progress Review Group meeting of the National Institute of Neurological Disorders and Stroke. It reflects the anatomical and the functional interconnected network existing between neurons, neuroglial cells, basal lamina matrix, and endothelial cells of brain microvessels. Maintenance of NVU integrity is essential for homeostasis of the central nervous system (CNS), and it is ensured by a multicellular bidirectional crosstalk. Several secreted neurotrophic and growth factors act in a paracrine manner, contributing to the correct development and function of both nervous and endothelial cells. Neurovascular unit impairment is linked to several CNS pathological conditions leading to epigenetic reprogramming within NVU cells. In this Special Issue of Life will be welcome papers dealing with molecular genetics and epigenetics applied to clarify mechanisms of neurovascular development and signaling. Moreover, the Special Issue aims to identify genetic, epigenetic, and epitranscriptomic factors associated to NVU properties that can contribute to NVU impairment. Therefore, original articles and reviews focusing on NVU physiology and pathology are highly encouraged, as well as papers aiming to better characterize the role of a single cell type in NVU crosstalk. Expression studies will also be considered. Finally, studies are not limited to human samples, and results obtained by in vitro observations and animal models are also accepted.
Dr. Concetta Scimone
Dr. Rosalia D’Angelo
Prof. Dr. Antonina Sidoti
Guest Editors
Manuscript Submission Information
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Keywords
- Neurovascular unit
- Neurovascular crosstalk
- Epigenetics
- Epitranscriptomics
- Molecular mechanisms
- Neurovascular development
- Neurovascular unit and diseases
