Endoscopic Procedures and Translational Aspects at the Skull Base

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (16 June 2023) | Viewed by 3226

Special Issue Editor


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Guest Editor
Center for Anatomy and Cell Biology, Medical University of Vienna, 1090 Wien, Austria
Interests: skull base; surgical approaches; clinical anatomy; endoscopy

Special Issue Information

Dear Colleagues,

The skull base is an important anatomical area of the human body, where the paths of distinguished surgical specialties, such as neurosurgery and ENT (Ear, Nose and Throat), cross. Here, the nasal and oral cavity as well as the cranial cavity with all their neurovascular structures, let alone the craniocervical junction, border on each other, building one of the anatomically most complex regions of the human body. Aside from the morphological challenges of the central nervous system encased in the skull and the vertebral column, the neurovascular pathways entering or entering the region distinguish this region and may be demanding when confronted with a pathology requiring surgical treatment.

As space in these osseous compartments is limited, minimally invasive approaches are necessary to address relevant pathologies. In this, endoscopic approaches play a major role for minimizing the surgical interference. Especially in designing new endoscopical pathways to locations at the skull base, exact topographical knowledge on involved anatomical structures and of their respective three-dimensional spatial relationships are essential.

As such, I am pleased to present this special issue on Endoscopic Procedures and Translational Aspects at the Skull Base. In this issue, not only new aspects of surgical approaches and treatment options on pathologies of the skull base will be presented. Especially manuscripts with a basic science approach on different facets of anatomy of the skull base as well as including imaging modalities are also in the thematic scope of this issue.

Dr. Lena Hirtler
Guest Editor

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Keywords

  • skull base
  • endoscopic approaches
  • clinical anatomy
  • cranial fossa
  • nasal cavity
  • orbita
 

Published Papers (2 papers)

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9 pages, 2728 KiB  
Article
Positioning Transclival Tumor-Treating Fields for the Treatment of Diffuse Intrinsic Pontine Gliomas
by Walid Ibn Essayed, Casey A. Jarvis, Joshua D. Bernstock, Anna Slingerland, John Albanese, Gregory K. Friedman, Omar Arnaout and Lissa Baird
Life 2023, 13(3), 601; https://0-doi-org.brum.beds.ac.uk/10.3390/life13030601 - 21 Feb 2023
Cited by 2 | Viewed by 1937
Abstract
Diffuse intrinsic pontine glioma (DIPG) carries an extremely poor prognosis, with 2-year survival rates of <10% despite the maximal radiation therapy. DIPG cells have previously been shown to be sensitive to low-intensity electric fields in vitro. Accordingly, we sought to determine if the [...] Read more.
Diffuse intrinsic pontine glioma (DIPG) carries an extremely poor prognosis, with 2-year survival rates of <10% despite the maximal radiation therapy. DIPG cells have previously been shown to be sensitive to low-intensity electric fields in vitro. Accordingly, we sought to determine if the endoscopic endonasal (EE) implantation of an electrode array in the clivus would be feasible for the application of tumor-treating fields (TTF) in DIPG. Anatomic constraints are the main limitation in pediatric EE approaches. In our Boston Children’s Hospital’s DIPG cohort, we measured the average intercarotid distance (1.68 ± 0.36 cm), clival width (1.62 ± 0.19 cm), and clival length from the base of the sella (1.43 ± 0.69 cm). Using a linear regression model, we found that only clival length and sphenoid pneumatization were significantly associated with age (R2 = 0.568, p = 0.005 *; R2 = 0.605, p = 0.0002 *). Critically, neither of these parameters represent limitations to the implantation of a device within the dimensions of those currently available. Our findings confirm that the anatomy present within this age group is amenable to the placement of a 2 × 1 cm electrode array in 94% of patients examined. Our work serves to demonstrate the feasibility of implantable transclival devices for the provision of TTFs as a novel adjunctive therapy for DIPG. Full article
(This article belongs to the Special Issue Endoscopic Procedures and Translational Aspects at the Skull Base)
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21 pages, 930 KiB  
Systematic Review
Quantitative Anatomical Studies in Neurosurgery: A Systematic and Critical Review of Research Methods
by Edoardo Agosti, Lucio De Maria, Pier Paolo Mattogno, Giuseppe Maria Della Pepa, Ginevra Federica D’Onofrio, Alessandro Fiorindi, Liverana Lauretti, Alessandro Olivi, Marco Maria Fontanella and Francesco Doglietto
Life 2023, 13(9), 1822; https://0-doi-org.brum.beds.ac.uk/10.3390/life13091822 - 28 Aug 2023
Cited by 1 | Viewed by 821
Abstract
Background: The anatomy laboratory can provide the ideal setting for the preclinical phase of neurosurgical research. Our purpose is to comprehensively and critically review the preclinical anatomical quantification methods used in cranial neurosurgery. Methods: A systematic review was conducted following the PRISMA guidelines. [...] Read more.
Background: The anatomy laboratory can provide the ideal setting for the preclinical phase of neurosurgical research. Our purpose is to comprehensively and critically review the preclinical anatomical quantification methods used in cranial neurosurgery. Methods: A systematic review was conducted following the PRISMA guidelines. The PubMed, Ovid MEDLINE, and Ovid EMBASE databases were searched, yielding 1667 papers. A statistical analysis was performed using R. Results: The included studies were published from 1996 to 2023. The risk of bias assessment indicated high-quality studies. Target exposure was the most studied feature (81.7%), mainly with area quantification (64.9%). The surgical corridor was quantified in 60.9% of studies, more commonly with the quantification of the angle of view (60%). Neuronavigation-based methods benefit from quantifying the surgical pyramid features that define a cranial neurosurgical approach and allowing post-dissection data analyses. Direct measurements might diminish the error that is inherent to navigation methods and are useful to collect a small amount of data. Conclusion: Quantifying neurosurgical approaches in the anatomy laboratory provides an objective assessment of the surgical corridor and target exposure. There is currently limited comparability among quantitative neurosurgical anatomy studies; sharing common research methods will provide comparable data that might also be investigated with artificial intelligence methods. Full article
(This article belongs to the Special Issue Endoscopic Procedures and Translational Aspects at the Skull Base)
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