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Marine Drugs
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Marine Bioactives in Food and Medicine—Selected Papers from 6th International...
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Marine Bioactives in Food and Medicine—Selected Papers from 6th International Symposium on Phytochemicals in Medicine and Food (6-ISPMF)

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 2665

Special Issue Editors

Prof. Dr. Shucheng Liu

E-Mail Website
Guest Editor
College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China
Interests: seafood science & technology; food technology; food gel; food science
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Maria Daglia

E-Mail Website
Guest Editor
Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
Interests: food chemistry and analysis; food supplements; functional foods; chromatographic and spectrophotometric methods; natural compounds; polyphenols; antioxidant activity; anti- inflammatory activity; epigenetic effect of food components-mirnas; preclinical studies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, which is related to the 6th International Symposium on Phytochemicals in Medicine and Food (6-ISPMF, Hangzhou, August 5–10, 2022), seeks an updated and new knowledge on natural products from marine environments. Marine drugs and functional foods have received increased attention due to their considerable benefits for human health. This Special Issue will shape the future research directions for the important marine bioresources. Our purpose is to feature high-quality, advanced research and knowledge contributed by various research groups all around the world working on marine natural products. We invite researchers to contribute reviews and reports of their recent work on the functional and nutritional properties of natural products from marine as well as the biotechnological improvements. Please note that registration to 6th International Symposium on Phytochemicals in Medicine and Food is obligatory for acceptance.

The Special Issue will focus on natural products from marine environments, including the following aspects:

  • Natural products from marine environments for preventing and managing modern diseases;
  • Importance of functional foods from marine environments for human health;
  • Bioactivity and function of edible marine plants and animals;
  • New strategy of using marine drugs for promoting human health;
  • Pharmacokinetics and biotransformation of marine drugs;
  • Biotechnology for yielding bioactive components from marine environments.

Prof. Dr. Shucheng Liu
Prof. Dr. Maria Daglia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products from marine resources
  • edible marine plants and animals
  • natural products
  • bioactive peptides
  • food chemistry
  • nutrition
  • metabolism
  • prevention
  • chemoprevention
  • functional food
  • pharmacokinetics
  • biotransformation
  • bioactivity
  • structure-activity relationship

Published Papers (1 paper)

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Research

22 pages, 5375 KiB  
Article
Antioxidant Activity of Gracilaria lemaneiformis Polysaccharide Degradation Based on Nrf-2/Keap-1 Signaling Pathway in HepG2 Cells with Oxidative Stress Induced by H2O2
by Xiaoshan Long, Xiao Hu, Chuang Pan, Huan Xiang, Shengjun Chen, Bo Qi, Shucheng Liu and Xianqing Yang
Mar. Drugs 2022, 20(9), 545; https://0-doi-org.brum.beds.ac.uk/10.3390/md20090545 - 24 Aug 2022
Cited by 14 | Viewed by 2140
Abstract
The objective of this research was to investigate the antioxidant activity of Gracilarialemaneiformis polysaccharide degradation and its underlying mechanism involved in the Nrf-2/Keap-1 signaling pathway in HepG2 cells with oxidative stress induced by H2O2. The result of the [...] Read more.
The objective of this research was to investigate the antioxidant activity of Gracilarialemaneiformis polysaccharide degradation and its underlying mechanism involved in the Nrf-2/Keap-1 signaling pathway in HepG2 cells with oxidative stress induced by H2O2. The result of the scavenging ability of free radicals showed that GLP-HV (polysaccharide degraded by H2O2–vitamin C (Vc)) performed a better scavenging ability than GLP (G.lemaneiformis polysaccharide). Moreover, the scavenging ability of polysaccharide to these free radicals from strong to weak was as follows: superoxide radical, ferric ion, ABTS+, and DPPH radical, and their IC50 values were 3.56 ± 0.0028, 4.97 ± 0.18, 9.62 ± 0.35, and 23.85 ± 1.78 mg/mL, respectively. Furthermore, GLP-HV obviously relieved oxidative stress in HepG2 cells, which strengthened the activity of T-AOC, CAT, GSH-PX, and SOD, and diminished the intensity of MDA, intracellular ROS, and calcium ion based on the Nrf-2/Keap-1 signaling pathway. The PCR result revealed that polysaccharide upregulated the expression of the genes Nrf-2, HO-1, NQO-1, and ZO-1 and downregulated Keap-1. The correlation between chemical properties and antioxidant mechanism of GLP-HV was evaluated via a heat map. The results illustrated that reducing sugar and active groups presented a positive correlation, and molecular weight and viscosity exhibited a negative relation with antioxidant activity. Full article
(This article belongs to the Special Issue Marine Bioactives in Food and Medicine—Selected Papers from 6th International Symposium on Phytochemicals in Medicine and Food (6-ISPMF))
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