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Special Issue Information

Dear colleagues,

Lipoproteins are complex particles that have a central hydrophobic core of non-polar lipids, primarily cholesterol esters and triglycerides, which is surrounded by a hydrophilic membrane consisting of phospholipids, free cholesterol, and apolipoproteins. Disorders of lipoproteins often lead to disease in humans. The sequelae of long-term dyslipoproteinemia often lead to atherosclerotic vascular disease in all arterial beds. The plasma elevation of low-density lipoprotein cholesterol, very low-density lipoproteins and lipoprotein(a), and reduced levels of high-density lipoprotein cholesterol are risk factors for coronary artery disease. Severe elevations of plasma triglycerides may lead to acute pancreatitis.

Oxidative stress resulting from cell metabolism, as well as from extracellular processes, is recognized as one of the primary processes underlying the initiation and progression of miscellaneous disorders. Because of the close interactions of plasma lipoproteins with vascular endothelial cells and the susceptibility of their surface lipids to oxidative modification, plasma lipoproteins are good biological sensors of oxidative stress in the vessel wall. Therefore, understanding the susceptibility of lipoproteins and cell membrane lipids to oxidative modification is essential for preventing the development of affected diseases.

The aim of this Special Issue is to provide update data linking changes in the oxidative modifications of lipoproteins, membrane lipid peroxidation and disease development.

This Special Issue aims to promote studies focused on lipoproteins and cell membrane lipids (e.g., small dense low-density lipoprotein, lipoprotein(a)) and disease, including reviews and experimental studies.

Kind regards,
Dr. Ming-Yow Hung
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Membranes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

oxidative stress
lipoproteins
lipids

Published Papers (2 papers)

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Research

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19 pages, 26539 KiB

Open AccessArticle

Homo Sapiens (Hsa)-microRNA (miR)-6727-5p Contributes to the Impact of High-Density Lipoproteins on Fibroblast Wound Healing In Vitro

by Khaled Mahmoud Bastaki, Jamie Maurice Roy Tarlton, Richard James Lightbody, Annette Graham and Patricia Esther Martin

Membranes 2022, 12(2), 154; https://0-doi-org.brum.beds.ac.uk/10.3390/membranes12020154 - 27 Jan 2022

Cited by 2 | Viewed by 2420

Abstract

Chronic, non-healing wounds are a significant cause of global morbidity and mortality, and strategies to improve delayed wound closure represent an unmet clinical need. High-density lipoproteins (HDL) can enhance wound healing, but exploitation of this finding is challenging due to the complexity and instability of these heterogeneous lipoproteins. The responsiveness of primary human neonatal keratinocytes, and neonatal and human dermal fibroblasts (HDF) to HDL was confirmed by cholesterol efflux, but promotion of ‘scrape’ wound healing occurred only in primary human neonatal (HDFn) and adult fibroblasts (HDFa). Treatment of human fibroblasts with HDL induced multiple changes in the expression of small non-coding microRNA sequences, determined by microchip array, including hsa-miR-6727-5p. Intriguingly, levels of hsa-miR-6727-5p increased in HDFn, but decreased in HDFa, after exposure to HDL. Delivery of a hsa-miR-6727-5p mimic elicited repression of different target genes in HDFn (ZNF584) and HDFa (EDEM3, KRAS), and promoted wound closure in HDFn. By contrast, a hsa-miR-6727-5p inhibitor promoted wound closure in HDFa. We conclude that HDL treatment exerts distinct effects on the expression of hsa-miR-6727-5p in neonatal and adult fibroblasts, and that this is a sequence which plays differential roles in wound healing in these cell types, but cannot replicate the myriad effects of HDL. Full article

(This article belongs to the Special Issue The Role of Lipoproteins and Cell Membrane Lipids in Disease)

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Review

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12 pages, 666 KiB

Open AccessReview

Role of Lipoproteins in the Pathophysiology of Breast Cancer

by Santhi Latha Pandrangi, Prasanthi Chittineedi, Rajasekhar Chikati, Juan Alejandro Neira Mosquera, Sungey Naynee Sánchez Llaguno, Gooty Jaffer Mohiddin, Suseela Lanka, Sphoorthi Shree Chalumuri and Narendra Maddu

Membranes 2022, 12(5), 532; https://0-doi-org.brum.beds.ac.uk/10.3390/membranes12050532 - 19 May 2022

Cited by 11 | Viewed by 3098

Abstract

Breast cancer is one of the most common malignancies in women and the leading cause of cancer mortality. Hypercholesterolemia and obesity are potential risk factors for the incidence of breast cancer, and their detection can enhance cancer prevention. In this paper, we discuss the current state of investigations on the importance of lipoproteins, such as low denisity lipoproteins (LDL) and high density lipoproteins (HDL), and cholesterol transporters in the progression of breast cancer, and the therapeutic strategies to reduce breast cancer mortality. Although some research has been unsuccessful at uncovering links between the roles of lipoproteins and breast cancer risk, major scientific trials have found a straight link between LDL levels and incidence of breast cancer, and an inverse link was found between HDL and breast cancer development. Cholesterol and its transporters were shown to have significant importance in the development of breast cancer in studies on breast cancer cell lines and experimental mice models. Instead of cholesterol, 27-hydroxycholesterol, which is a cholesterol metabolite, is thought to promote propagation and metastasis of estrogen receptor-positive breast cancer cell lines. Alteration of lipoproteins via oxidation and HDL glycation are thought to activate many pathways associated with inflammation, thereby promoting cellular proliferation and migration, leading to metastasis while suppressing apoptosis. Medications that lower cholesterol levels and apolipoprotein A-I mimics have appeared to be possible therapeutic agents for preventing excessive cholesterol’s role in promoting the development of breast cancer. Full article

(This article belongs to the Special Issue The Role of Lipoproteins and Cell Membrane Lipids in Disease)

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