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Micromachines
Special Issues
Electrochemical (Bio)sensors for Biomarkers Analysis
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Electrochemical (Bio)sensors for Biomarkers Analysis

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (10 February 2019) | Viewed by 7693

Special Issue Editors

Prof. Dr. Muhammad J. A. Shiddiky

E-Mail Website
Guest Editor
1. School of Environment and Science, Griffith University, Nathan Campus, 170 Kessels Road, Nathan, QLD 4111, Australia
2. Queensland Micro- and Nanotechnology Centre, Griffith University, Nathan Campus, 170 Kessels Road, Nathan, QLD 4111, Australia
Interests: point-of-care devices; molecular diagnostics; microfluidics devices; electrochemical sensors
Special Issues, Collections and Topics in MDPI journals
Dr. Muhammad Umer

E-Mail Website
Guest Editor
Queensland Micro- and Nanotechnology Centre, Griffith University, Nathan Campus, 170 Kessels Road, Nathan, QLD 4111, Australia
Interests: biosensors; lab-on-a-chip; liquid biopsy; electrochemical nucleic acid sensors; point-of-need testing; cancer biology; epigenetics

Special Issue Information

Dear Colleagues,

Electrochemical biosensors have gained broad attention over the years, not only due to their inherent sensitivity and specificity, but also because of their potential for portability and amenability to miniaturization. Recent progress in the fields of microfluidics, micro/nanofabrication, as well as development of novel conducting and electroactive polymers, functionalised nanomaterials, bionanoconjugates, and electrodes have paved the way for commercialisation and wide ranging application of electrochemical sensors. The importance of electrochemical sensors for biomonitoring and biomarker analysis in environmental, industrial, agricultural, and above all clinical applications is increasingly being recognised. In clinical settings, electrochemical sensing devices have proven to be specifically helpful for personalised medicine, precision theranostics, as well as minimally invasive diagnostic applications. This Special Issue will focus on recent developments in electrochemical biosensing platforms, especially those that may enable point-of-care and field testing.

Dr. Muhammad J. A. Shiddiky
Dr. Muhammad Umer
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Diagnostic
  • micro and nanodevices
  • personalized medicine
  • liquid biopsy
  • arrayed microbiosensors
  • molecular devices
  • circulating tumor cells (CTCs) analysis
  • circulating tumor DNA (ctDNA)
  • biomarkers
  • biosensors
  • immunosensors
  • nanomaterials
  • conducting polymers

Published Papers (2 papers)

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Research

14 pages, 3680 KiB  
Article
Single-Molecule Detection of DNA in a Nanochannel by High-Field Strength-Assisted Electrical Impedance Spectroscopy
by Porpin Pungetmongkol and Takatoki Yamamoto
Micromachines 2019, 10(3), 189; https://0-doi-org.brum.beds.ac.uk/10.3390/mi10030189 - 15 Mar 2019
Cited by 5 | Viewed by 3930
Abstract
Many researchers have fabricated micro and nanofluidic devices incorporating optical, chemical, and electrical detection systems with the aim of achieving on-chip analysis of macromolecules. The present study demonstrates a label-free detection of DNA using a nanofluidic device based on impedance measurements that is [...] Read more.
Many researchers have fabricated micro and nanofluidic devices incorporating optical, chemical, and electrical detection systems with the aim of achieving on-chip analysis of macromolecules. The present study demonstrates a label-free detection of DNA using a nanofluidic device based on impedance measurements that is both sensitive and simple to operate. Using this device, the electrophoresis and dielectrophoresis effect on DNA conformation and the length dependence were examined. A low alternating voltage was applied to the nanogap electrodes to generate a high intensity field (>0.5 MV/m) under non-faradaic conditions. In addition, a 100 nm thick gold electrode was completely embedded in the substrate to allow direct measurements of a solution containing the sample passing through the gap, without any surface modification required. The high intensity field in this device produced a dielectrophoretic force that stretched the DNA molecule across the electrode gap at a specific frequency, based on back and forth movements between the electrodes with the DNA in a random coil conformation. The characteristics of 100 bp, 500 bp, 1 kbp, 5 kbp, 10 kbp, and 48 kbp λ DNA associated with various conformations were quantitatively analyzed with high resolution (on the femtomolar level). The sensitivity of this system was found to be more than about 10 orders of magnitude higher than that obtained from conventional linear alternating current (AC) impedance for the analysis of bio-polymers. This new high-sensitivity process is expected to be advantageous with regard to the study of complex macromolecules and nanoparticles. Full article
(This article belongs to the Special Issue Electrochemical (Bio)sensors for Biomarkers Analysis)
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12 pages, 2066 KiB  
Article
Wireless Electrochemical Detection on a Microfluidic Compact Disc (CD) and Evaluation of Redox-Amplification during Flow
by Maria Bauer, Jaume Bartoli, Sergio O. Martinez-Chapa and Marc Madou
Micromachines 2019, 10(1), 31; https://0-doi-org.brum.beds.ac.uk/10.3390/mi10010031 - 07 Jan 2019
Cited by 12 | Viewed by 3621
Abstract
Novel biomarkers and lower limits of detection enable improved diagnostics. In this paper we analyze the influence of flow on the lower limit of electrochemical detection on a microfluidic Compact Disc (CD). Implementing wireless transfer of data reduces noise during measurements and allows [...] Read more.
Novel biomarkers and lower limits of detection enable improved diagnostics. In this paper we analyze the influence of flow on the lower limit of electrochemical detection on a microfluidic Compact Disc (CD). Implementing wireless transfer of data reduces noise during measurements and allows for real time sensing, demonstrated with the ferri-ferroyanide redox-couple in single and dual mode cyclic voltammetry. The impact of flow on redox-amplification and electrode integration for the lowest limit of detection are discussed. Full article
(This article belongs to the Special Issue Electrochemical (Bio)sensors for Biomarkers Analysis)
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