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Micromachines
Special Issues
Microfluidic Devices for Biomedical Applications and Pathogen Detection
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Microfluidic Devices for Biomedical Applications and Pathogen Detection

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "E：Engineering and Technology".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 8218

Special Issue Editors

Dr. Chin Hong Ooi

E-Mail Website
Guest Editor
Queensland Micro- and Nanotechnology Centre, Griffith University, 170 Kessels Rd, Nathan, QLD 4111, Australia
Interests: liquid marbles; digital microfluidics; lab-on-a-chip devices; 3D printing; optical tensiometry; electrostatics; dielectrophoresis; colloids and interface science; 3D cell culture; cell stretching
Dr. Sreejith Kamalalayam Rajan

E-Mail Website
Guest Editor
Queensland Micro- and Nanotechnology Centre, Griffith University, 170 Kessels Rd, Nathan, QLD 4111, Australia
Interests: liquid-marble-based digital microfluidics; conventional microfluidics; point-of-care diagnostics; lab-on-a-chip devices; biomedical instrumentation; customized instrument design

Special Issue Information

Dear colleagues,

Microfluidics has revolutionized the area of disease diagnosis and pathogen detection in the last two decades. Biomedical microdevices and point-of-care diagnostic tools developed using microfluidic techniques have made a significant impact in recent years. Advancements in conventional continuous flow microfluidics, digital microfluidics, paper-based microfluidics, liquid marbles, and core–shell beads-based microfluidics have made their contribution to this “microfluidics revolution” in biomedical applications and pathogen detection. Conventional microfluidic devices are famous for their significantly low use of reagents, compactness, and ease of handling compared to their conventional counterparts. Recently, the development of liquid-marbles-based microfluidics and microfluidic techniques based on core–shell beads were proven to be the most environmentally friendly platforms compared to conventional techniques. Accordingly, this Special Issue invites papers reporting novel microfluidic devices and/or techniques with specific applications in biomedical engineering, point-of-care disease diagnosis, and pathogen detection.

We look forward to receiving your submissions!

Dr. Chin Hong Ooi
Dr. Sreejith Kamalalayam Rajan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Microfluidic Devices
  • Point of care disease diagnosis
  • Lab on a Chip
  • Biomedical microdevices

Published Papers (2 papers)

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Research

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9 pages, 1578 KiB  
Article
A Portable Device for LAMP Based Detection of SARS-CoV-2
by Kamalalayam Rajan Sreejith, Muhammad Umer, Larissa Dirr, Benjamin Bailly, Patrice Guillon, Mark von Itzstein, Narshone Soda, Surasak Kasetsirikul, Muhammad J. A. Shiddiky and Nam-Trung Nguyen
Micromachines 2021, 12(10), 1151; https://0-doi-org.brum.beds.ac.uk/10.3390/mi12101151 - 24 Sep 2021
Cited by 11 | Viewed by 2707
Abstract
This paper reports the design, development, and testing of a novel, yet simple and low-cost portable device for the rapid detection of SARS-CoV-2. The device performs loop mediated isothermal amplification (LAMP) and provides visually distinguishable images of the fluorescence emitted from the samples. [...] Read more.
This paper reports the design, development, and testing of a novel, yet simple and low-cost portable device for the rapid detection of SARS-CoV-2. The device performs loop mediated isothermal amplification (LAMP) and provides visually distinguishable images of the fluorescence emitted from the samples. The device utilises an aluminium block embedded with a cartridge heater for isothermal heating of the sample and a single-board computer and camera for fluorescence detection. The device demonstrates promising results within 20 min using clinically relevant starting concentrations of the synthetic template. Time-to-signal data for this device are considerably lower compared to standard quantitative Polymerase Chain Reaction(qPCR) machine (~10–20 min vs. >38 min) for 1 × 102 starting template copy number. The device in its fully optimized and characterized state can potentially be used as simple to operate, rapid, sensitive, and inexpensive platform for population screening as well as point-of-need severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) detection and patient management. Full article
(This article belongs to the Special Issue Microfluidic Devices for Biomedical Applications and Pathogen Detection)
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Review

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70 pages, 21000 KiB  
Review
Acoustic Biosensors and Microfluidic Devices in the Decennium: Principles and Applications
by Minu Prabhachandran Nair, Adrian J. T. Teo and King Ho Holden Li
Micromachines 2022, 13(1), 24; https://0-doi-org.brum.beds.ac.uk/10.3390/mi13010024 - 26 Dec 2021
Cited by 20 | Viewed by 4774
Abstract
Lab-on-a-chip (LOC) technology has gained primary attention in the past decade, where label-free biosensors and microfluidic actuation platforms are integrated to realize such LOC devices. Among the multitude of technologies that enables the successful integration of these two features, the piezoelectric acoustic wave [...] Read more.
Lab-on-a-chip (LOC) technology has gained primary attention in the past decade, where label-free biosensors and microfluidic actuation platforms are integrated to realize such LOC devices. Among the multitude of technologies that enables the successful integration of these two features, the piezoelectric acoustic wave method is best suited for handling biological samples due to biocompatibility, label-free and non-invasive properties. In this review paper, we present a study on the use of acoustic waves generated by piezoelectric materials in the area of label-free biosensors and microfluidic actuation towards the realization of LOC and POC devices. The categorization of acoustic wave technology into the bulk acoustic wave and surface acoustic wave has been considered with the inclusion of biological sample sensing and manipulation applications. This paper presents an approach with a comprehensive study on the fundamental operating principles of acoustic waves in biosensing and microfluidic actuation, acoustic wave modes suitable for sensing and actuation, piezoelectric materials used for acoustic wave generation, fabrication methods, and challenges in the use of acoustic wave modes in biosensing. Recent developments in the past decade, in various sensing potentialities of acoustic waves in a myriad of applications, including sensing of proteins, disease biomarkers, DNA, pathogenic microorganisms, acoustofluidic manipulation, and the sorting of biological samples such as cells, have been given primary focus. An insight into the future perspectives of real-time, label-free, and portable LOC devices utilizing acoustic waves is also presented. The developments in the field of thin-film piezoelectric materials, with the possibility of integrating sensing and actuation on a single platform utilizing the reversible property of smart piezoelectric materials, provide a step forward in the realization of monolithic integrated LOC and POC devices. Finally, the present paper highlights the key benefits and challenges in terms of commercialization, in the field of acoustic wave-based biosensors and actuation platforms. Full article
(This article belongs to the Special Issue Microfluidic Devices for Biomedical Applications and Pathogen Detection)
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