Digitally Manufactured Microfluidics and Microsystems

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "D3: 3D Printing and Additive Manufacturing".

Deadline for manuscript submissions: closed (10 December 2022) | Viewed by 7363

Special Issue Editors


E-Mail Website
Guest Editor
Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
Interests: microfluidics; 3D-printing; cancer; organ-on-a-chip; BioMEMS
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Mechanical Engineering, Koç University, Sariyer, 34450 Istanbul, Turkey
Interests: 3D printed microfluidics; portable diagnostic devices; health monitoring devices; magnetics; bioprinting
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Mechanical Engineering, Concordia University, Montréal, QC H3G2W1, Canada
Interests: nano-bio interactions; biosensors; optical BIoMEMS
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Mechanical Engineering, Concordia University, Montréal, QC H3G2W1, Canada
Interests: additive manufacturing; high-intensity focused ultrasound; holograms and metamaterials for ultrasound; micro-electro-mechanical systems; intelligent manufacturing; virtual manufacturing; CAD/CAM/CAE; multi-axis cnc machining and grinding; gear manufacturing; advanced cutting tool design
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We would like to propose a 100% discount on six quotas and a 66% discount on six quotas for high-quality publications in this Special Issue:

Eligibility for the discount:
– Submission before the deadline 10 December 2022;
– Open to all career levels;
– Both reviews and articles will be considered.

Selection Criteria:
The winners will be selected by the Guest Editors according to the following criteria:
– Scientific merit and broad impact;
– Originality of the research objectives and/or the ideas presented;
– Creativity of the study design or uniqueness of the approaches and concepts;
– Peer reviewers’ comments (no rejection from reviewers);
– Clarity of presentation.

Prizes:
–The respective winners of six “first prizes” can publish a paper with a 100% discount in this Special Issue (original price—CHF 2000);
–The respective winners of six “second prizes” can publish a paper with a 66% discount in this Special Issue (original price—CHF 2000).

Submission, Peer-review and Evaluation process:
1. Submit your paper before the deadline on 10 December 2022 via this link (https://susy.mdpi.com/user/manuscripts/upload/fd473cb4c9207a18fbf83d4334a67f55?form%5Bjournal_id%5D=22&form%5Bspecial_issue_id%5D=122491). Please mention whether you would like to join this featured-papers-contest in the cover letter during submission;
2. Submissions follow a peer review process;
3. Guest editors will begin to evaluate the contest candidates after they are accepted from the peer review process. If not participating in the contest, regular submissions will not wait for the evaluation process and will be accepted directly after peer review;
4. After evaluation, the contest candidates will be accepted—the six “first prizes” winners will receive an invoice of CHF 0, and the six “second prizes” winners will receive an invoice of CHF 680.

In the last two decades, the vast majority of microfluidic systems have been built in poly(dimethylsiloxane) (PDMS) by soft lithography, a technique based on PDMS micromolding. A long list of key PDMS properties have contributed to the success of soft lithography: PDMS is biocompatible, elastomeric, transparent, gas-permeable, water-impermeable, fairly inexpensive, copyright-free, and rapidly prototyped with high precision using simple procedures. However, the fabrication process typically involves substantial human labor, which tends to make PDMS devices difficult to disseminate outside of research labs. More industry-friendly alternatives to PDMS such as the micromolding or micromachining of thermoplastics have been presented. However, the layered molding limits the 3D complexity of the devices that can be produced. Digital manufacturing (DM) is a family of computer-centered processes that integrate digital 3D designs, automated (additive or subtractive) fabrication, and device testing in order to increase fabrication efficiency. Importantly, DM enables the inexpensive realization of 3D designs that are impossible or very difficult to mold. This Special Issue showcases research papers, short communications, and review papers that highlight the latest developments in the DM of microfluidics and microsystems, including additive or subtractive manufacturing processes such as stereolithograpy (SLA), digital light processing (DLP)-based SLA, two-photon direct laser writing (DLW), Continuous Liquid Interface Printing (CLIP), PolyJet, fused deposition modeling (FDM), direct sound printing (DSP), volumetric printing, laser cutting, CNC milling, 3D-printed molds, and bioprinting, particularly advances in resins and resolution and the biological, biochemical, biophysical, and biomedical applications of additive manufacturing. Following the example of the preceding 2020 Special Issue on the same theme, this Issue will be published as an open-source book of wide dissemination and impact. 

We would like to cordially invite you to participate in this featured-papers-contest, publish research or review articles with us and enjoy the impact of open access publishing with Micromachines.

Prof. Dr. Albert Folch
Prof. Dr. Savas Tasoglu
Prof. Dr. Muthukumaran Packirisamy
Dr. Mohsen Habibi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • 3D printing
  • additive manufacturing
  • direct write lithography
  • microfluidics
  • photochemistry
  • sonochemistry
  • polymerization
  • CNC milling

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Other

15 pages, 2939 KiB  
Article
3D-Printed Dip Slides Miniaturize Bacterial Identification and Antibiotic Susceptibility Tests Allowing Direct Mastitis Sample Analysis
by Tai The Diep, Samuel Bizley and Alexander Daniel Edwards
Micromachines 2022, 13(6), 941; https://0-doi-org.brum.beds.ac.uk/10.3390/mi13060941 - 14 Jun 2022
Viewed by 2774
Abstract
The early detection of antimicrobial resistance remains an essential step in the selection and optimization of antibiotic treatments. Phenotypic antibiotic susceptibility testing including the measurement of minimum inhibitory concentration (MIC) remains critical for surveillance and diagnostic testing. Limitations to current testing methods include [...] Read more.
The early detection of antimicrobial resistance remains an essential step in the selection and optimization of antibiotic treatments. Phenotypic antibiotic susceptibility testing including the measurement of minimum inhibitory concentration (MIC) remains critical for surveillance and diagnostic testing. Limitations to current testing methods include bulky labware and laborious methods. Furthermore, the requirement of a single strain of bacteria to be isolated from samples prior to antibiotic susceptibility testing delays results. The mixture of bacteria present in a sample may also have an altered resistance profile to the individual strains, and so measuring the susceptibility of the mixtures of organisms found in some samples may be desirable. To enable simultaneous MIC and bacterial species detection in a simple and rapid miniaturized format, a 3D-printed frame was designed for a multi-sample millifluidic dip-slide device that combines panels of identification culture media with a range of antibiotics (Ampicillin, Amoxicillin, Amikacin, Ceftazidime, Cefotaxime, Ofloxacin, Oxytetracycline, Streptomycin, Gentamycin and Imipenem) diluted in Muëller–Hinton Agar. Our proof-of-concept evaluation confirmed that the direct detection of more than one bacterium parallel to measuring MIC in samples is possible, which is validated using reference strains E. coli ATCC 25922, Klebsiella pneumoniae ATCC 13883, Pseudomonas aeruginosa ATCC 10145, and Staphylococcus aureus ATCC 12600 and with mastitis milk samples collected from Reading University Farm. When mixtures were tested, a MIC value was obtained that reflected the most resistant organism present (i.e., highest MIC), suggesting it may be possible to estimate a minimum effective antibiotic concentration for mixtures directly from samples containing multiple pathogens. We conclude that this simple miniaturized approach to the rapid simultaneous identification and antibiotic susceptibility testing may be suitable for directly testing agricultural samples, which is achieved through shrinking conventional tests into a simple “dip-and-incubate” device that can be 3D printed anywhere. Full article
(This article belongs to the Special Issue Digitally Manufactured Microfluidics and Microsystems)
Show Figures

Figure 1

Other

Jump to: Research

10 pages, 1893 KiB  
Perspective
3D-Printed Microneedles for Point-of-Care Biosensing Applications
by Misagh Rezapour Sarabi, Sattar Akbari Nakhjavani and Savas Tasoglu
Micromachines 2022, 13(7), 1099; https://0-doi-org.brum.beds.ac.uk/10.3390/mi13071099 - 13 Jul 2022
Cited by 21 | Viewed by 3170
Abstract
Microneedles (MNs) are an emerging technology for user-friendly and minimally invasive injection, offering less pain and lower tissue damage in comparison to conventional needles. With their ability to extract body fluids, MNs are among the convenient candidates for developing biosensing setups, where target [...] Read more.
Microneedles (MNs) are an emerging technology for user-friendly and minimally invasive injection, offering less pain and lower tissue damage in comparison to conventional needles. With their ability to extract body fluids, MNs are among the convenient candidates for developing biosensing setups, where target molecules/biomarkers are detected by the biosensor using the sample collected with the MNs. Herein, we discuss the 3D printing of microneedle arrays (MNAs) toward enabling point-of-care (POC) biosensing applications. Full article
(This article belongs to the Special Issue Digitally Manufactured Microfluidics and Microsystems)
Show Figures

Figure 1

Back to TopTop