Recent Advances of Micromachines in Medicine & Biology

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B:Biology and Biomedicine".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 3207

Special Issue Editor


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Guest Editor

Special Issue Information

Dear Colleagues,

The world market for microdevices in both medicine and in biology is expanding rapidly. This also presents new challenges for the microsystem community to meet these often-demanding requirements. Micromachines offer many opportunities for both sensors and actuators. Accordingly, we hereby announce a Special Issue addressing the advances in micromachines in medicine and biology. These devices are typically in the range from the sub-mm to the nano-meter scale. We invite submissions on all aspects of the development of micromachines in both these fields. Examples of topics include implantable sensors and actuators, wearable devices, microfluidic devices and systems, microrobots, energy scavenging, etc. Related novel system concepts and application proposals are acceptable contributions. Within each of these areas, there are issues such as technology, power, safety, design, packaging, etc. Contributions covering any of these issues for micromachines when applied to medicine and biology will be considered.

Prof. Dr. Paddy J. French
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • micromachining
  • micropumps
  • microfluidic systems
  • implantable devices
  • wearable MEMS
  • microrobots
  • energy scavenging
  • flexible MEMS

Published Papers (1 paper)

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Research

14 pages, 1763 KiB  
Article
An Integrated Pulsation-Free, Backflow-Free Micropump Using the Analog Waveform-Driven Braille Actuator
by Kotaro Nishikata, Masataka Nakamura, Yuto Arai and Nobuyuki Futai
Micromachines 2022, 13(2), 294; https://0-doi-org.brum.beds.ac.uk/10.3390/mi13020294 - 13 Feb 2022
Cited by 2 | Viewed by 2220
Abstract
The widespread adoption of long-term organs-on-a-chip culture necessitates both active perfusions that mimic physiological flow conditions and minimization of the complexity of microfluidic system and fluid handling. In particular, flow in microtissue such as microvascular is free of pulsation and backflow. The refreshable [...] Read more.
The widespread adoption of long-term organs-on-a-chip culture necessitates both active perfusions that mimic physiological flow conditions and minimization of the complexity of microfluidic system and fluid handling. In particular, flow in microtissue such as microvascular is free of pulsation and backflow. The refreshable Braille actuator-based integrated microfluidic system can be employed with simple microchannels and setups. However, due to high pulsatile flow and backflow, ordinary Braille-driven micropumps generate non-physiological flow conditions. We have described a simple method for creating steady flow employing Braille actuators driven with a high-voltage analog waveform, called “constant flow waveform”, without incorporating complicated structures into the microchannel or actuator. We determined the constant flow waveform by measuring volume change of microchannel caused by actuated Braille pins using a conventional fluorescent dye and microscope. Using the constant flow waveform, we demonstrated that a Braille-driven pump reduced pulsating flow by 79% and backflow by 63% compared to conventional Braille-driven pump. Furthermore, we demonstrated that a parallel pair of three-stranded pin pumps effectively eliminated backflow by driving two pumps with the constant flow waveform half-cycle shifted to each other. Moreover, by raising the driving frequency, we could increase the average flow rate to ~2× higher than previously reported flow rate of a typical Braille-driven micropump. Full article
(This article belongs to the Special Issue Recent Advances of Micromachines in Medicine & Biology)
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