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Microorganisms
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Human Skin Microbiota 2.0
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Human Skin Microbiota 2.0

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 15 May 2024 | Viewed by 7801

Special Issue Editors

Prof. Dr. Holger Brüggemann

E-Mail Website
Guest Editor
Department of Biomedicine, Aarhus University, Skou Building, Høegh-Guldbergs Gade 10, 8000 Aarhus C, Denmark
Interests: skin microbiota; skin microbiome; Cutibacteria; Cutibacterium acnes; acne; coagulase-negative staphylococci; Finegoldia; Clostridium tetani; implant-associated infections; prosthetic joint infections
Special Issues, Collections and Topics in MDPI journals
Dr. Rolf Lood

E-Mail Website
Guest Editor
Biomedical Center, Lunds Universitet, Lund, Sweden
Interests: benevolent bacteria; skin microbiota; bacteriophages; Cutibacterium acnes; antimicrobial resistance
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the continuation of our previous special issue "Human Skin Microbiota".

The human skin is colonized by complex communities of bacteria, fungi, and viruses. Different skin sites host their own microbial communities, with a large interpersonal variation. There are also some common trends such as the abundance of cutibacteria and coagulase-negative staphylococci at certain skin sites. Recent years also highlighted the large intraspecific diversity, for example, concerning the bacterial species Cutibacterium acnes and Staphylococcus epidermidis.

We are beginning to understand microbial population dynamics on human skin and the underlying shaping factors, such as interferences of skin microorganisms, as well as the functional impact of the skin microbiota, including species- and strain-specific host-interacting properties and their consequences.

The objective of this Special Issue of Microorganisms is to present latest research regarding the human skin microbiota in health and disease and insights into the microbiology and genomics of individual skin microorganisms. This also includes technical procedures and exploratory studies to investigate the composition and function of the skin microbiome. In addition, this Special Issue aims to present research regarding health-beneficial and -detrimental effects of the skin microbiota and the possible exploitation and modulation for skin barrier-protective therapeutic strategies, including pre- and probiotic solutions. Original research articles, as well as review articles, are invited.

Prof. Dr. Holger Brüggemann
Dr. Rolf Lood
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin microbiota
  • skin microbiome
  • skin metagenome
  • skin microorganism
  • Staphylococcus
  • Cutibacterium
  • Corynebacterium
  • Finegoldia, Malassezia
  • phage
  • population genetics
  • microbial genomics
  • next generation sequencing
  • strain diversity
  • antimicrobials bacterial interference
  • immune system interaction
  • colonization resistance
  • prebiotics
  • probiotics

Published Papers (5 papers)

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Research

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12 pages, 1657 KiB  
Article
Women Skin Microbiota Modifications during Pregnancy
by Giulia Radocchia, Francesca Brunetti, Massimiliano Marazzato, Valentina Totino, Bruna Neroni, Giulia Bonfiglio, Antonietta Lucia Conte, Fabrizio Pantanella, Paola Ciolli and Serena Schippa
Microorganisms 2024, 12(4), 808; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms12040808 - 17 Apr 2024
Viewed by 519
Abstract
Several studies have shown fluctuations in the maternal microbiota at various body sites (gut, oral cavity, and vagina). The skin microbiota plays an important role in our health, but studies on the changes during pregnancy are limited. Quantitative and qualitative variations in the [...] Read more.
Several studies have shown fluctuations in the maternal microbiota at various body sites (gut, oral cavity, and vagina). The skin microbiota plays an important role in our health, but studies on the changes during pregnancy are limited. Quantitative and qualitative variations in the skin microbiota in pregnant woman could indeed play important roles in modifying the immune and inflammatory responses of the host. These alterations could induce inflammatory disorders affecting the individual’s dermal properties, and could potentially predict infant skin disorder in the unborn. The present study aimed to characterize skin microbiota modifications during pregnancy. For this purpose, skin samples were collected from 52 pregnant women in the first, second, and third trimester of non-complicated pregnancies and from 17 age- and sex-matched healthy controls. The skin microbiota composition was assessed by next generation sequencing (NGS) of the V3–V4 region of the bacterial rRNA 16S. Our results indicate that from the first to the third trimester of pregnancy, changes occur in the composition of the skin microbiota, microbial interactions, and various metabolic pathways. These changes could play a role in creating more advantageous conditions for fetal growth. Full article
(This article belongs to the Special Issue Human Skin Microbiota 2.0)
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12 pages, 2380 KiB  
Article
Leucobacter manosquensis sp. nov.—A Novel Bacterial Species Isolated from Healthy Human Skin
by Manon Boxberger, Sibylle Magnien, Angeline Antezack, Clara Rolland, Marine Makoa Meng, Cheikh Ibrahima Lo, Bernard La Scola and Nadim Cassir
Microorganisms 2023, 11(10), 2535; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms11102535 - 11 Oct 2023
Viewed by 1038
Abstract
Extending our knowledge on human skin microbiota is a challenge to better decipher its role in health and disease. Using the culturomics method, we isolated strain Marseille-Q4368 from the healthy forehead of a 59-year-old woman. We describe here the main characteristics of this [...] Read more.
Extending our knowledge on human skin microbiota is a challenge to better decipher its role in health and disease. Using the culturomics method, we isolated strain Marseille-Q4368 from the healthy forehead of a 59-year-old woman. We describe here the main characteristics of this bacterium using a taxonogenomic approach. This new bacterial species is Gram-positive, non-motile, and non-spore-forming. Its 16S rRNA sequence exhibited a similarity of 99.59% with Leucobacter chromiiresistens, the most closely related species in terms of nomenclature. However, a digital DNA–DNA hybridization analysis between these two species revealed a maximum identity similarity of only 27.5%. We found phenotypical and genomic differences between strain Marseille-Q4368 and its closely related species. These findings underscore the classification of this bacterium as a distinct species. Hence, we propose the name Leucobacter manosquensis sp. nov. strain Marseille-Q4368 (=CSUR Q4368 = DSM 112403) for this newly identified bacterial species. Full article
(This article belongs to the Special Issue Human Skin Microbiota 2.0)
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15 pages, 3954 KiB  
Article
Oxygen Exposure and Tolerance Shapes the Cell Wall-Associated Lipids of the Skin Commensal Cutibacterium acnes
by Iuliana Popa, David Touboul, Tilde Andersson, Eduardo Fuentes-Lemus, Cyrille Santerre, Michael J. Davies and Rolf Lood
Microorganisms 2023, 11(9), 2260; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms11092260 - 08 Sep 2023
Viewed by 1052
Abstract
Cutibacterium acnes is one of the most abundant bacteria on the skin. Being exposed to oxygen and oxic stress, the secretion of the bacterial antioxidant protein RoxP ensures an endogenous antioxidant system for the preservation of skin health. To investigate the impact of [...] Read more.
Cutibacterium acnes is one of the most abundant bacteria on the skin. Being exposed to oxygen and oxic stress, the secretion of the bacterial antioxidant protein RoxP ensures an endogenous antioxidant system for the preservation of skin health. To investigate the impact of the antioxidant RoxP on oxidation of the bacteria, wildtype and an isogenic roxp mutant were cultured in anaerobic and oxic conditions. The carbonylated status of proteins were recorded, as were the most significant modifications in a relative intensity of free fatty acids (FFA) and lipids containing fatty acids (FA), such as di- (DG) and triglycerides (TG), di- (DGDG) and sulfoquinozyldiacylglycerol (SQDG) and ceramides. Concerning the fatty acid types, it was observed that the free fatty acids contained mainly C12:0–C26:0 in hydroxy and acylated forms, the DG contained mainly C29:0–C37:0, the TG contained mainly C19:0–C33:0, and the DGDG/SQDGs contained very long fatty acids (C29:0–C37:0) demonstrating the interdependence of de novo synthesis of lipids and RoxP. The area of DGDG peaks (924.52, 929.56 and 930.58) were affected by bacterial growth conditions, with the exception of m/z 910.61. Moreover, the FFA unsaturation is wider in the SQDG species (C30:0 to C36:6) than in DG, TG or free FFA species. It could be concluded that both environmental oxidative statuses, as well as the prevalence of bacterial antioxidant systems, significantly shape the lipidome of C. acnes. Full article
(This article belongs to the Special Issue Human Skin Microbiota 2.0)
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Review

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23 pages, 5012 KiB  
Review
Plant-Based Films and Hydrogels for Wound Healing
by Ana I. Lopes, Maria M. Pintado and Freni K. Tavaria
Microorganisms 2024, 12(3), 438; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms12030438 - 21 Feb 2024
Viewed by 1254
Abstract
Skin is constantly exposed to injury and infectious agents that can compromise its structural integrity and cause wounds. When this occurs, microorganisms from the skin microbiota and external bacteria and fungi can penetrate the wound and cause an infection, which complicates the healing [...] Read more.
Skin is constantly exposed to injury and infectious agents that can compromise its structural integrity and cause wounds. When this occurs, microorganisms from the skin microbiota and external bacteria and fungi can penetrate the wound and cause an infection, which complicates the healing process. Nowadays, there are several types of wound dressings available to treat wounds, some of which are incorporated with antimicrobial agents. However, the number of microorganisms resistant to these substances is rising. Therefore, the search for new, natural alternatives such as essential oils (EOs) and plant extracts (PEs) is on the rise. However, these substances present some limitations (poor bioavailability and poor target capacity), which limits their efficiency. Their incorporation in formulations in the form of films and hydrogels (HGs) can help to overcome these issues and may be a potential alternative to the current treatments. HGs and films incorporated with PEs and EOs have antimicrobial activity, promote the viability of skin cells and fibroblast migration, and are non-toxic and biocompatible. This review discusses the use of films and HGs for the topical delivery of EOs and PEs for wound treatment and their formulations as effective wound dressings, while debating some mechanisms and biological properties to elucidate their presumptive clinical relevance and possible applications. Full article
(This article belongs to the Special Issue Human Skin Microbiota 2.0)
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24 pages, 1420 KiB  
Review
Bioprospecting the Skin Microbiome: Advances in Therapeutics and Personal Care Products
by Keir Nicholas-Haizelden, Barry Murphy, Michael Hoptroff and Malcolm J. Horsburgh
Microorganisms 2023, 11(8), 1899; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms11081899 - 27 Jul 2023
Cited by 4 | Viewed by 3113
Abstract
Bioprospecting is the discovery and exploration of biological diversity found within organisms, genetic elements or produced compounds with prospective commercial or therapeutic applications. The human skin is an ecological niche which harbours a rich and compositional diversity microbiome stemming from the multifactorial interactions [...] Read more.
Bioprospecting is the discovery and exploration of biological diversity found within organisms, genetic elements or produced compounds with prospective commercial or therapeutic applications. The human skin is an ecological niche which harbours a rich and compositional diversity microbiome stemming from the multifactorial interactions between the host and microbiota facilitated by exploitable effector compounds. Advances in the understanding of microbial colonisation mechanisms alongside species and strain interactions have revealed a novel chemical and biological understanding which displays applicative potential. Studies elucidating the organismal interfaces and concomitant understanding of the central processes of skin biology have begun to unravel a potential wealth of molecules which can exploited for their proposed functions. A variety of skin-microbiome-derived compounds display prospective therapeutic applications, ranging from antioncogenic agents relevant in skin cancer therapy to treatment strategies for antimicrobial-resistant bacterial and fungal infections. Considerable opportunities have emerged for the translation to personal care products, such as topical agents to mitigate various skin conditions such as acne and eczema. Adjacent compound developments have focused on cosmetic applications such as reducing skin ageing and its associated changes to skin properties and the microbiome. The skin microbiome contains a wealth of prospective compounds with therapeutic and commercial applications; however, considerable work is required for the translation of in vitro findings to relevant in vivo models to ensure translatability. Full article
(This article belongs to the Special Issue Human Skin Microbiota 2.0)
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