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Microorganisms
Special Issues
Inter-kingdom Signaling—Chemical Communication between Bacteria and Eukaryotes
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Inter-kingdom Signaling—Chemical Communication between Bacteria and Eukaryotes

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Systems Microbiology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 2008

Special Issue Editor

Prof. Dr. Ralf Heermann

E-Mail Website
Guest Editor
Biocenter II, Microbiology and Biotechnology, Institute of Molecular Physiology (imP), Johannes Gutenberg University Mainz, Hanns-Dieter-Hüsch-Weg 17, 55128 Mainz, Germany
Interests: bacterial cell-cell communication; inter-kingdom signaling; bacterial signal transduction; bacteria-host interactions; entomopathogenic bacteria; bacterial biofilms; drug research

Special Issue Information

Dear Colleagues,

It is well recognized that bacteria can communicate with each other via small diffusible molecules to manage group-coordinated behavior, a process termed quorum sensing. However, this cell-cell communication is not restricted to bacteria. Recent research has given evidence that similar systems also allow communication between bacteria and their eukaryotic hosts and vice versa. Bacteria and eukaryotes have co-evolved for millions of years. Therefore, it is obvious that communication between bacterial symbionts or pathogens with plants, animals, and humans as well as with eukaryotic microorganisms such as fungi is important for their co-existence. Bacteria have learned to eavesdrop hormone systems of their hosts to adapt and adequately regulate symbiosis and pathogenicity, but also to manipulate eukaryotic chemical communication to survive.

This Special Issue invites research articles on inter-kingdom signaling, especially on novel communication molecules but also on the response mechanisms of bacteria upon host detection. Since inter-kingdom signaling systems are often involved in regulation of pathogenicity, they represent promising targets for novel antimicrobials. Therefore, research articles focusing on inhibition strategies of inter-kingdom signaling are also welcome.

Prof. Dr. Ralf Heermann
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inter-kingdom signaling
  • chemical communication
  • small-molecule signaling
  • hormones
  • bacteria-host interactions
  • novel antimicrobials

Published Papers (1 paper)

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Research

18 pages, 3759 KiB  
Article
Interkingdom Signaling of the Insect Pathogen Photorhabdus luminescens with Plants Via the LuxR solo SdiA
by Nazzareno Dominelli, Alice Regaiolo, Leon Willy and Ralf Heermann
Microorganisms 2023, 11(4), 890; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms11040890 - 30 Mar 2023
Viewed by 1537
Abstract
In bacteria, group-coordinated behavior such as biofilm formation or virulence are often mediated via cell–cell communication, a process referred to as quorum sensing (QS). The canonical QS system of Gram-negative bacteria uses N-acyl homoserine lactones (AHLs) as communication molecules, which are produced [...] Read more.
In bacteria, group-coordinated behavior such as biofilm formation or virulence are often mediated via cell–cell communication, a process referred to as quorum sensing (QS). The canonical QS system of Gram-negative bacteria uses N-acyl homoserine lactones (AHLs) as communication molecules, which are produced by LuxI-type synthases and sensed by cognate LuxR-type receptors. These receptors act as transcriptional regulators controlling the expression of specific genes. Some bacteria harbor LuxR-type receptors lacking a cognate LuxI-type synthases, designated as LuxR solos. Among many other LuxR solos, the entomopathogenic enteric bacterium Photorhabdus luminescens harbors a SdiA-like LuxR solo containing an AHL signal-binding domain, for which a respective signal molecule and target genes have not been identified yet. Here we performed SPR analysis to demonstrate that SdiA acts as a bidirectional regulator of transcription, tightly controlling its own expression and the adjacent PluDJC_01670 (aidA) gene in P. luminescens, a gene supposed to be involved in the colonization of eukaryotes. Via qPCR we could further determine that in sdiA deletion mutant strains, aidA is upregulated, indicating that SdiA negatively affects expression of aidA. Furthermore, the ΔsdiA deletion mutant exhibited differences in biofilm formation and motility compared with the wild-type. Finally, using nanoDSF analysis we could identify putative binding ability of SdiA towards diverse AHLs, but also to plant-derived signals, modulating the DNA-binding capacity of SdiA, suggesting that this LuxR solo acts as an important player in interkingdom signaling between P. luminescens and plants. Full article
(This article belongs to the Special Issue Inter-kingdom Signaling—Chemical Communication between Bacteria and Eukaryotes)
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