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Microorganisms
Special Issues
Research on Natural Products against Pathogens
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Research on Natural Products against Pathogens

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: 30 May 2024 | Viewed by 1305

Special Issue Editor

Dr. Ana R. Díaz-Marrero

E-Mail Website
Guest Editor
Instituto de Productos Naturales y Agrobiología (IPNA), Consejo Superior de Investigaciones Científicas (CSIC), Avenida Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain
Interests: marine natural products; marine microbial compounds; bioassay-guided isolation; NMR structural analysis; biomedical applications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Infectious diseases have always represented a threat to humans, and they have been overcome through the discovery of antibiotics and antiviral agents. In addition to the most frequent antibiotic-resistant strains, the COVID-19 pandemic reactivated global concerns about emerging pathogens, leading to infections that are more difficult to treat.

The main natural products used as pharmaceuticals have evolved to become structurally diverse and unique and have a high biological affinity and specificity. Most antimicrobial drugs currently used in clinics originate from or are inspired by natural products, and thus, they will continue to be important raw materials for the development of new drugs.

The aim of this Special Issue of Microoorganisms is to cover the new findings and advances in the chemistry and biology of antimicrobial natural molecules, comprising novel structural features, biosynthetic studies, metabolomic studies, as well as their biological activities and mechanisms of action. Review articles that make substantial advances within this field will also be considered.

In this Special Issue of Microorganisms, scientists are encouraged to contribute to the advancement and future directions in the field of antipathogenic natural products.

Dr. Ana R. Diaz-Marrero
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • secondary metabolites
  • biological activity
  • antimicrobial
  • antibacterial
  • antiviral
  • antiparasitic
  • pathogens
  • microorganisms

Published Papers (1 paper)

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Research

20 pages, 6157 KiB  
Article
Efficacy of Penicillium limosum Strain AK-7 Derived Bioactive Metabolites on Antimicrobial, Antioxidant, and Anticancer Activity against Human Ovarian Teratocarcinoma (PA-1) Cell Line
by Dhanyakumara Shivapoojar Basavarajappa, Shaik Kalimulla Niazi, Asmatanzeem Bepari, Rasha Assad Assiri, Syed Arif Hussain, Muzaheed, Sreenivasa Nayaka, Halaswamy Hiremath, Muthuraj Rudrappa, Bidhayak Chakraborty and Anil Hugar
Microorganisms 2023, 11(10), 2480; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms11102480 - 03 Oct 2023
Cited by 1 | Viewed by 999
Abstract
Natural metabolites from beneficial fungi were recognized for their potential to inhibit multidrug-resistant human and plant fungal pathogens. The present study describes the isolation, metabolite profiling, antibacterial, and antifungal, antioxidant, and anticancer activities of soil fungi. Among the 17 isolates, the AK-7 isolate [...] Read more.
Natural metabolites from beneficial fungi were recognized for their potential to inhibit multidrug-resistant human and plant fungal pathogens. The present study describes the isolation, metabolite profiling, antibacterial, and antifungal, antioxidant, and anticancer activities of soil fungi. Among the 17 isolates, the AK-7 isolate was selected based on the primary screening. Further, the identification of isolate AK-7 was performed by 18S rRNA sequencing and identified as Penicillium limosum (with 99.90% similarity). Additionally, the ethyl acetate extract of the Penicillium limosum strain AK-7 (AK-7 extract) was characterized by Fourier Transform Infrared Spectroscopy (FTIR) and a Gas Chromatography-Mass Spectroscopy (GC-MS) analysis, and the results showed different functional groups and bioactive metabolites. Consequently, a secondary screening of antibacterial activity by the agar well diffusion method showed significant antibacterial activity against Gram-negative and Gram-positive bacterial pathogens. The AK-7 extract exhibited notable antifungal activity by a food poisoning method and showed maximum inhibition of 77.84 ± 1.62%, 56.42 ± 1.27%, and 37.96 ± 1.84% against Cercospora canescens, Fusarium sambucinum and Sclerotium rolfsii phytopathogens. Consequently, the AK-7 extract showed significant antioxidant activity against DPPH and ABTS•+ free radicals with IC50 values of 59.084 μg/mL and 73.36 μg/mL. Further, the anticancer activity of the AK-7 extract against the human ovarian teratocarcinoma (PA-1) cell line was tested by MTT and Annexin V flow cytometry. The results showed a dose-dependent reduction in cell viability and exhibited apoptosis with an IC50 value of 82.04 μg/mL. The study highlights the potential of the Penicillium limosum strain AK-7 as a source of active metabolites and natural antibacterial, antifungal, antioxidant, and anticancer agent, and it could be an excellent alternative for pharmaceutical and agricultural sectors. Full article
(This article belongs to the Special Issue Research on Natural Products against Pathogens)
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