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Microorganisms
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Group B Streptococcus
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Group B Streptococcus

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: closed (15 December 2021) | Viewed by 2788

Special Issue Editors

Dr. Jennifer Angeline Gaddy

E-Mail Website
Guest Editor
Vanderbilt University Medical Center, Nashville, TN, USA
Interests: protein structure and function; imaging
Dr. Kristen Noble

E-Mail Website
Guest Editor
Vanderbilt University Medical Center, Nashville, TN, USA
Interests: placental immune system; infection in pregnancy; neonatal immunology

Special Issue Information

Dear Colleagues,

Streptococcus agalactiae or Group B Streptococcus (GBS) is a Gram-positive, encapsulated bacterial pathogen that commonly colonizes the gastrointestinal and urogenital tract. Up to half of surveyed patients exhibit GBS colonization during pregnancy in some populations. GBS colonization is a strong risk factor for adverse outcomes during pregnancy such as chorioamnionitis, preterm premature rupture of gestational membranes, preterm birth, maternal sepsis, neonatal sepsis, and death. This Special Issue will seek to determine the environmental factors as well as bacterial and immunological mechanisms associated with GBS pathogenesis which ultimately influence disease outcomes.

Dr. Jennifer Angeline Gaddy
Dr. Kristen Noble
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Group B Streptococcus
  • preterm birth
  • pregnancy
  • premature rupture of membranes
  • chorioamnionitis
  • immunology
  • maternal–fetal interface
  • infectious disease
  • placenta
  • vagina
  • reproductive health

Published Papers (1 paper)

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Research

13 pages, 1906 KiB  
Article
Complicated Streptococcus agalactiae Sepsis with/without Meningitis in Young Infants and Newborns: The Clinical and Molecular Characteristics and Outcomes
by Chih Lin, Shih-Ming Chu, Hsiao-Chin Wang, Peng-Hong Yang, Hsuan-Rong Huang, Ming-Chou Chiang, Ren-Huei Fu, Ming-Horng Tsai and Jen-Fu Hsu
Microorganisms 2021, 9(10), 2094; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms9102094 - 03 Oct 2021
Cited by 6 | Viewed by 2242
Abstract
Background: Streptococcus agalactiae (also known as group B streptococcus, GBS) is associated with high mortality and morbidity rates in infants, especially those with complicated GBS sepsis, defined as those with meningitis, severe sepsis and/or septic shock. We aimed to characterize the clinical and [...] Read more.
Background: Streptococcus agalactiae (also known as group B streptococcus, GBS) is associated with high mortality and morbidity rates in infants, especially those with complicated GBS sepsis, defined as those with meningitis, severe sepsis and/or septic shock. We aimed to characterize the clinical and molecular characteristics and risk factors for adverse outcomes of neonates with invasive GBS diseases. Methods: From 2003 to 2020, all neonates with invasive GBS diseases who were hospitalized in a tertiary-level neonatal intensive care unit (NICU) were enrolled. The GBS isolates underwent serotyping, multilocus sequence typing (MLST) and antibiotic susceptibility testing. We compared cases of complicated GBS sepsis with uncomplicated GBS bacteremia. Results: During the study period, a total of 188 neonates (aged less than 6 months old) with invasive GBS diseases were identified and enrolled. Among them, 119 (63.3%) had uncomplicated GBS bacteremia and 69 (36.7%) neonates had complicated GBS sepsis, including meningitis (25.5%, n = 48) and severe sepsis or septic shock. Among neonates with complicated GBS sepsis, 45 (65.2%) had neurological complications, and 21 (42.0%) of 50 survivors had neurological sequelae at discharge. The overall final mortality rate was 10.1% (19 neonates died). Type III/ST-17 GBS isolates accounted for 56.5% of all complicated GBS sepsis and 68.8% of all GBS meningitis, but this strain was not significantly associated with worse outcomes. The antimicrobial resistance rate among the invasive GBS isolates was obviously increasing in the past two decades. After multivariate logistic regression analysis, neonates with thrombocytopenia and respiratory failure were independently associated with final adverse outcomes. Conclusions: a total of 36.7% of all neonatal invasive GBS diseases were associated with complicated sepsis with/without meningitis. Given the high mortality and morbidity rates in neonates with complicated GBS sepsis, further studies for early identification of specific strains, risk factors or genetic mechanisms that will cause complicated GBS sepsis are urgently needed in the future. Full article
(This article belongs to the Special Issue Group B Streptococcus)
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