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Microorganisms
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Probiotics for Inflammatory Bowel Diseases: Science, Clinical and Regulatory Issues
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Probiotics for Inflammatory Bowel Diseases: Science, Clinical and Regulatory Issues

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 9833

Special Issue Editors

Prof. Dr. Claudio de Simone

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Guest Editor
Department of Infectious Diseases, University of L’Aquila, 67100 L'Aquila, Italy
Interests: probiotics; human gut microflora
Prof. Dr. Paolo Gionchetti

E-Mail Website
Guest Editor
Alma Mater Studiorum Università di Bologna, Bologna, Italy
Interests: inflammatory bowel disease pathogenesis, diagnosis, and management
Dr. Massimiliano Marazzato

E-Mail Website
Guest Editor
Università degli Studi di Roma La Sapienza, Rome, Italy
Interests: antibiotics; PCR; bacteriology; microbial molecular biology; antimicrobial resistance; gel electrophoresis; general microbiology; DNA extraction; electrophoresis; DNA

Special Issue Information

Dear Colleagues,

This Special Issue on “Probiotics for Inflammatory Bowel Diseases: Science, Clinical, and Regulatory Issues” will serve as a forum for gathering articles based solely on facts around inflammatory bowel diseases (IBD). Inflammatory bowel diseases (IBD) are a group of impairing medical conditions, and as such, we have an obligation to respect people suffering from IBD by publishing works that are grounded on personal expertise and reliable scientific facts. Microbiologists, nutritionists, and immunologists who lack a medical background in IBD should thus not suggest or endorse therapeutic or preventive procedures—and at the same time, gastroenterologists should base their judgment solely on the substantiated results of well-controlled clinical trials. In this Special Issue, we also welcome articles from veterinarians treating animals with IBD, and from people challenging false advertising of probiotics for the prevention or treatment of IBD. As Editors, we discourage the submission of articles on topics such as “candidate probiotic strains”, “strain genetics” or “criteria or recommendations by a panel of experts”.

Prof. Dr. Claudio de Simone
Prof. Dr. Paolo Gionchetti
Dr. Massimiliano Marazzato
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

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16 pages, 2595 KiB  
Article
Effects of Prebiotics and Probiotics on Honey Bees (Apis mellifera) Infected with the Microsporidian Parasite Nosema ceranae
by Daniel Borges, Ernesto Guzman-Novoa and Paul H. Goodwin
Microorganisms 2021, 9(3), 481; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms9030481 - 25 Feb 2021
Cited by 37 | Viewed by 5029
Abstract
Nosema ceranae is a microsporidian fungus that parasitizes the midgut epithelial cells of honey bees, Apis mellifera. Due to the role that midgut microorganisms play in bee health and immunity, food supplementation with prebiotics and probiotics may assist in the control of [...] Read more.
Nosema ceranae is a microsporidian fungus that parasitizes the midgut epithelial cells of honey bees, Apis mellifera. Due to the role that midgut microorganisms play in bee health and immunity, food supplementation with prebiotics and probiotics may assist in the control of N. ceranae. The dietary fiber prebiotics acacia gum, inulin, and fructooligosaccharides, as well as the commercial probiotics Vetafarm Probotic, Protexin Concentrate single-strain (Enterococcus faecium), and Protexin Concentrate multi-strain (Lactobacillus acidophilus, L. plantarum, L. rhamnosus, L. delbrueckii, Bifidobacterium bifidum, Streptococcus salivarius, and E. faecium) were tested for their effect on N. ceranae spore loads and honey bee survivorship. Bees kept in cages were inoculated with N. ceranae spores and single-dose treatments were administered in sugar syrup. Acacia gum caused the greatest reduction in N. ceranae spore numbers (67%) but also significantly increased bee mortality (62.2%). However, Protexin Concentrate single-strain gave similarly reduced spore numbers (59%) without affecting the mortality. In a second experiment, multiple doses of the probiotics revealed significantly reduced spore numbers with 2.50 mg/mL Vetafarm Probotic, and 0.25, 1.25, and 2.50 mg/mL Protexin Concentrate single-strain. Mortality was also significantly reduced with 1.25 mg/mL Protexin Concentrate single-strain. N. ceranae-inoculated bees fed 3.75 mg/mL Vetafarm Probotic had higher survival than N. ceranae-inoculated bees, which was similar to that of non-inoculated bees, while N. ceranae-inoculated bees fed 2.50 mg/mL Protexin Concentrate single-strain, had significantly higher survival than both N. ceranae-inoculated and non-inoculated bees. Protexin Concentrate single-strain is promising as it can reduce N. ceranae proliferation and increase bee survivorship of infected bees, even compared to healthy, non-infected bees. Full article
(This article belongs to the Special Issue Probiotics for Inflammatory Bowel Diseases: Science, Clinical and Regulatory Issues)
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Review

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19 pages, 582 KiB  
Review
Probiotic Shewanella putrefaciens (SpPdp11) as a Fish Health Modulator: A Review
by María Cámara-Ruiz, María Carmen Balebona, Miguel Ángel Moriñigo and María Ángeles Esteban
Microorganisms 2020, 8(12), 1990; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms8121990 - 14 Dec 2020
Cited by 36 | Viewed by 4264
Abstract
Aquaculture is considered one of the largest food production sectors in the world. Probiotics have long been considered as a beneficial tool in this industry since these microorganisms improve the welfare of different fish species by modulating several physiological functions, such as metabolism, [...] Read more.
Aquaculture is considered one of the largest food production sectors in the world. Probiotics have long been considered as a beneficial tool in this industry since these microorganisms improve the welfare of different fish species by modulating several physiological functions, such as metabolism, digestion, immune response, stress tolerance, and disease resistance, among others. SpPdp11, a probiotic isolated from the skin of healthy gilthead seabream, has been the center of attention in a good number of studies since its discovery. The purpose of this paper is to summarize, comment, and discuss the current knowledge related to the effects of SpPdp11 in two commercially important fish species in aquaculture (gilthead seabream and Senegalese sole). Furthermore, some considerations for future studies are also indicated. Full article
(This article belongs to the Special Issue Probiotics for Inflammatory Bowel Diseases: Science, Clinical and Regulatory Issues)
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