Molecular Biology of Viruses

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Virology".

Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 2321

Special Issue Editors


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Guest Editor
College of Medicine, The Ohio State University, Columbus, OH, USA
Interests: Retrovirus; biochemistry; biophysics; host-virus interactions; genome editing; integration

E-Mail Website
Guest Editor
College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA
Interests: pathogenesis; viral oncogenesis; retrovirology; molecular biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Eukaryotic viruses are perhaps the most important causes of pandemics. In recent years, outbreaks of SARS-CoV-2, Zika, and influenza A (H1N1) have significantly disrupted lives globally. After decades of research, HIV-1 continues to be a global pandemic. Although these viruses negatively impact human life, historically, viruses have also been important tools in the understanding of eukaryotic biology. Investigations of viruses inform our understanding of basic biology mechanisms and provide novel tools for molecular biology experiments. In turn, such molecular biology tools allow advanced studies of eukaryotic viruses, including genetic analysis and dissection of host–virus interactions.

In this Special Issue, we invite research papers and review articles focused on all aspects of the molecular biology of all eukaryotic viruses. Relevant topics include but are not limited to: genetic analysis, host–virus interactions, enzymology, as well as studies of all steps in viral life cycles from entry to exit.

Prof. Kristine E. Yoder
Prof. Amanda Panfil
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • eukaryotic viruses
  • viral replication
  • viral pathogenesis
  • viral oncogenesis
  • viral evolution
  • viral genetics
  • viral epitranscriptomics
  • host–virus interactions
  • molecular biology

Published Papers (1 paper)

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Review

12 pages, 896 KiB  
Review
Epigenetic Regulation of Human T-Cell Leukemia Virus Gene Expression
by Lee Ratner
Microorganisms 2022, 10(1), 84; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms10010084 - 31 Dec 2021
Cited by 3 | Viewed by 2024
Abstract
Viral and cellular gene expression are regulated by epigenetic alterations, including DNA methylation, histone modifications, nucleosome positioning, and chromatin looping. Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus associated with inflammatory disorders and T-cell lymphoproliferative malignancy. The transforming activity of [...] Read more.
Viral and cellular gene expression are regulated by epigenetic alterations, including DNA methylation, histone modifications, nucleosome positioning, and chromatin looping. Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus associated with inflammatory disorders and T-cell lymphoproliferative malignancy. The transforming activity of HTLV-1 is driven by the viral oncoprotein Tax, which acts as a transcriptional activator of the cAMP response element-binding protein (CREB) and nuclear factor kappa B (NFκB) pathways. The epigenetic effects of Tax and the induction of lymphoproliferative malignancy include alterations in DNA methylation and histone modifications. In addition, alterations in nucleosome positioning and DNA looping also occur in HTLV-1-induced malignant cells. A mechanistic definition of these effects will pave the way to new therapies for HTLV-1-associated disorders. Full article
(This article belongs to the Special Issue Molecular Biology of Viruses)
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