Current Status on Molecular Therapeutic Targets for Neurodegenerative Disorders
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (15 June 2021) | Viewed by 333
Special Issue Editors
Interests: drug discovery; therapeutic developments for cancer and neurodegenerative disorders; computational molecular modeling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodegenerative disease is an ensemble of over 600 diseases that affect millions worldwide. These diseases are characterized by a progressive loss of neuronal function leading to ataxia and/or dementia, with more severe forms causing death. Although there is plentiful ongoing research attempting to uncover the pathologies that lead to these neurodegenerative diseases, there are currently no available therapeutics that can either cure the diseases or address their progressive nature. The most common forms of neurodegenerative diseases are Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS). While neurodegenerative disorders tend to vary in clinical presentation, there are many pathological overlaps in their underlying mechanisms, including protein accumulation/misfolding/aggregation (seen in AD, PD, HD, and ALS), mitochondrial disfunction and oxidative stress (forms of AD, PD, HD, ALS), DNA damage/repair (AD, PD, ALS, ataxia telangiectasia, oculomotor apraxia), and intracellular transport (hereditary spastic paraplegia). As the molecular mechanisms underlying these various neurodegenerative diseases become better understood, they represent prime targets for therapeutic design in treating and potentially curing these disorders. Authors are invited to submit manuscripts to this Molecules Special Issue, “Current Status on Molecular Therapeutic Targets for Neurodegenerative Disorders”, in which all aspects related to molecular mechanisms, prime targets for therapeutic development, identification of biomarkers for diagnosis, agents in clinical trials, and challenges with current agents in various phases of clinical trials for neurodegenerative disorders may be addressed.
Dr. Jayalakshmi Sridhar
Dr. Thomas Huckaba
Guest Editors
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Keywords
- neurodegenerative disorders
- molecular targets
- biomarkers
- protein aggregation
- DNA damage and repair
- mitochondrion disorders
- therapeutic targets
- molecular pathways
- antibody target
- disease-specific selective target
