Research Advances in Organofluorine Chemistry

Dear Colleagues,

Organofluorine chemistry stands as a vibrant and pivotal field within the realm of organic synthesis and material science. The incorporation of fluorine atoms into organic molecules brings about a plethora of enhancements in their physical, chemical, and biological properties, leading to applications ranging from pharmaceuticals to advanced materials.

The significance of organofluorine compounds is vividly evident in modern society. Their utilization in drug design, agrochemical development, and materials engineering has propelled scientific innovation. The introduction of fluorine imparts desirable characteristics such as lipophilicity, increased metabolic stability, altered reactivity, and heightened bioactivity to molecules. This has translated into an impressive surge in the percentage of commercial pharmaceuticals and agrochemicals integrating fluorine moieties, with these figures continuously on the rise.

The synthesis of organofluorine compounds, however, is a challenging endeavor due to the scarcity of naturally occurring fluorinated molecules. Consequently, synthetic chemists have fervently explored various strategies to introduce fluorine atoms into organic substrates. Novel methodologies and versatile fluorine-containing reagents have emerged, diversifying the toolkit for creating fluorinated compounds. Moreover, fluorine-containing building blocks have proven invaluable in constructing complex molecules, further catalyzing advances in the field.

This Special Issue on Organofluorine Chemistry is dedicated to unraveling the latest breakthroughs, innovative methodologies, and exciting applications within this domain. Researchers are invited to contribute their work on novel synthetic routes, investigation of unique properties and interactions of organofluorine molecules, and their impact on diverse disciplines. This platform provides an opportunity to deepen our understanding of organofluorine chemistry's dynamic landscape and its continuous role in shaping modern science and technology.

Dr. Jin-Hong Lin
Guest Editor

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• fluorine fluorination reactions
• fluorine incorporation
• organic fluorine compounds
• novel fluorine-containing reagents
• fluorination synthetic strategies
• fluorine catalysis