Natural and Synthetic Coumarins and Derivatives
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 605
Special Issue Editor
Interests: asymmetric synthesis; synthesis of bidentant chiral ligands; fine organic synthesis; cross-metathesis reactions; CH activation; computer simulation of organic processes; some aspects of supramolecular chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Coumarin (2H-chromen-2-one) is a natural lactone found in many plants, where it may serve as a chemical defense against predators, mostly due to its appetite-suppressing properties and bitter taste, which may discourage animals from eating plants that contain it.
In fact, the toxicity of coumarin is quite low, so it is used as a popular pleasant-smelling fragrance ingredient in perfumes, soaps, detergents, and lotions with additional fragrance-enhancing and stabilizing functionality.
There are some medical applications of coumarin in anticoagulant, venoactive, and antineoplastic drugs. Coumarin-based compounds have found application as “turn-on” fluorescence probes for the imaging of certain peptides (e.g., in Alzheimer's disease).
Despite the limited medical application of coumarin itself, the motif of coumarin is widely used in a number of synthetic drugs and drug candidates. For example, coumarin-3-carboxylic acid is used in radiotherapy, coumarin 2-hydroxycinnamic acid is used in the treatment of glaucoma patients, and furano(pyrano)coumarins have been found to have anticancer, anti-inflammatory, and antibacterial activity. These new findings shed light on the highly potent applicability of substituted coumarins in different fields of medicine, and promise a bright future for coumarins in medical applications.
Some technical application of coumarin based dyes are also known—for example, coumarin-based compounds have a potential to be used in optoelectronics, in new solar cells, and in laser applications.
In the Special Issue titled "Natural and Synthetic Coumarins and Derivatives" we will explore the chemistry, biochemistry, medical and pharmaceutical chemistry, as well as physics of coumarin-core-based compounds, and will present their outlooks and perspectives.
Prof. Dr. Oleg M. Demchuk
Guest Editor
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Keywords
- coumarin
- 2H-chromen-2-one
- biological activity
- drug candidates
- drug discovery
- fluorescent properties
- organic solar cell
- tunable organic dye lasers
