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Advances in Bioactive Nanoparticles on Wound Healing, Tissue Engineering and Drug Delivery

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A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 10 June 2024 | Viewed by 6255

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Special Issue Editors

Dr. Tamara Posati

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Guest Editor

Institute of organic synthesis and photoreactivity (ISOF-CNR), Rome, Italy
Interests: inorganic lamellar solids; hydrotalcites; hybrid materials; nanocomposites; biomaterials; silk fibroin extraction; purification and processing

Dr. Annalisa Aluigi

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Guest Editor

Institute of organic synthesis and photoreactivity (ISOF-CNR), Rome, Italy
Interests: biopolymer processing; electrospinning; nanocomposites; keratin nanofibers and nanoparticles; drug delivery systems; wound healing system

Dr. Giovanna Sotgiu

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Guest Editor

Institute of organic synthesis and photoreactivity (ISOF-CNR), Rome, Italy
Interests: fluorescent dyes; photoactive compounds; biomaterials; biopolymers; drug delivery systems

Special Issue Information

Dear Colleagues,

In recent years, a lot of research has been directed towards the study of bioactive inorganic, organic, and/or hybrid nanoparticles in the biomedical field. These nanomaterials play an important role in drug delivery, imaging, diagnostics, wound healing, and tissue engineering applications. In this respect, different materials have been studied and investigated, such as iron oxide, gold and silver nanoparticles, polymeric nanoparticles, lamellar solids, and nanocomposites. We invite authors to contribute original research or review articles covering the most recent progress and novel developments in the synthesis, design, use, and characterization of different nanoparticles and nanocomposites for drug delivery, tissue engineering, wound healing, and, more generally, for biomedical technologies. This Special Issue aims to cover a broad range of subjects, from nanoparticle synthesis to characterization and application. The welcomed study formats include full papers, communications, and reviews. Potential topics include, but are not limited to:

Nanoparticle and nanocomposite development, synthesis, and fabrication for drug delivery, drug release, and tissue engineering;
Inorganic, organic, and hybrid nanoparticles;
Nanoparticle-based technologies for biomedical applications;
Characterization of nanoparticles and nanocomposites and the study of their biocompatibility/toxicity towards different cell lines.

We look forward to receiving your contributions.

Dr. Tamara Posati
Dr. Annalisa Aluigi
Dr. Giovanna Sotgiu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

nanoparticles
nanocomposites
biomedical applications
drug delivery
drug release

Published Papers (4 papers)

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Research

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12 pages, 2661 KiB

Open AccessArticle

The Effect of Nanobubbles on Transdermal Applications

by Athanasios Ch. Mitropoulos, Christina Pappa, Ramonna I. Kosheleva and George Z. Kyzas

Nanomaterials 2023, 13(18), 2600; https://0-doi-org.brum.beds.ac.uk/10.3390/nano13182600 - 20 Sep 2023

Viewed by 1000

Abstract

In the present work, a new method for dermal delivery using nanobubbles (NBs) is investigated. Oxygen NBs are generated in deionized water and used to produce cosmetic formulations with hyaluronic acid as an active ingredient. Nanobubbles result in the improvement of the effect and penetration of the active ingredient through Strat-M, a synthetic membrane that resembles human skin. Experiments conducted with the Franz Cell device confirm the greater penetration of the active ingredient into Strat-M due to NBs, compared to cosmetic formulations that do not contain NBs. The effect of NBs was further examined by measuring UV-Vis and FTIR spectra. A possible mechanism was outlined, too. It was also found that NBs do not change the pH or the FTIR spectrum of the cosmetic serum indicating non-toxicity. Full article

(This article belongs to the Special Issue Advances in Bioactive Nanoparticles on Wound Healing, Tissue Engineering and Drug Delivery)

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16 pages, 5711 KiB

Open AccessArticle

Immobilization of Alendronate on Zirconium Phosphate Nanoplatelets

by Anna Donnadio, Geo Paul, Marianna Barbalinardo, Valeria Ambrogi, Gabriele Pettinacci, Tamara Posati, Chiara Bisio, Riccardo Vivani and Morena Nocchetti

Nanomaterials 2023, 13(4), 742; https://0-doi-org.brum.beds.ac.uk/10.3390/nano13040742 - 15 Feb 2023

Viewed by 1157

Abstract

Different amounts of sodium-alendronate (ALN) were loaded into layered zirconium phosphates of alpha and gamma type (αZP and γZP) by means of topotactic exchange reactions of phosphate with ALN. In order to extend the exchange process to the less accessible interlayer regions, ALN solutions were contacted with colloidal dispersions of the layered solids previously exfoliated in single sheets by means of intercalation reaction of propylamine (for αZP) or acetone (for γZP). The ALN loading degree was determined by liquid P-nuclear magnetic resonance (NMR) and inductively coupled plasma (ICP), and it was reported as ALN/Zr molar ratios (Rs). The maximum R obtained for γZP was 0.34, while αZP was able to load a higher amount of ALN, reaching Rs equal to 1. The synthesized compounds were characterized by X-ray powder diffractometry, scanning electron microscopy (SEM), solid-state NMR, and infrared spectroscopy. The way the grafted organo-phosphonate groups were bonded to the layers of the host structure was suggested. The effect of ZP derivatives was assessed on cell proliferation, and the results showed that after 7 days of incubation, none of the samples showed a decrease in cell proliferation. Full article

(This article belongs to the Special Issue Advances in Bioactive Nanoparticles on Wound Healing, Tissue Engineering and Drug Delivery)

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25 pages, 8012 KiB

Open AccessArticle

Green Synthesis and Characterization of Iron Nanoparticles Synthesized from Aqueous Leaf Extract of Vitex leucoxylon and Its Biomedical Applications

by Mohammed H. Nahari, Amer Al Ali, Abdulaziz Asiri, Mater H. Mahnashi, Ibrahim Ahmed Shaikh, Arun K. Shettar and Joy Hoskeri

Nanomaterials 2022, 12(14), 2404; https://0-doi-org.brum.beds.ac.uk/10.3390/nano12142404 - 14 Jul 2022

Cited by 11 | Viewed by 2135

Abstract

The cold extraction method was used to obtain the aqueous extract of Vitex leucoxylon leaves in a ratio of 1:10. Iron nanoparticles (FeNPs) were synthesized using aqueous leaf extract of V. leucoxylon as a reducing agent. The phytoreducing approach was used to make FeNPs by mixing 1 mL of plant extract with 1 mM of ferric sulfate. Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), Ultraviolet–visible spectroscopy (UV-Vis), and energy-dispersive X-ray spectroscopy were used to examine the synthesized FeNPs. The reducing reaction was shown by a change in the color of the solution, and the formation of black color confirms that FeNPs have been formed. The greatest absorption peak (max) was found at 395 nm in UV-Vis spectral analysis. The FTIR spectra of V. leucoxylon aqueous leaf extract showed shifts in some peaks, namely 923.96 cm⁻¹ and 1709.89 cm⁻¹, with functional groups carboxylic acids, unsaturated aldehydes, and ketones, which were lacking in the FTIR spectra of FeNPs and are responsible for FeNPs formation. FeNPs with diameters between 45 and 100 nm were observed in SEM images. The creation of FeNPs was confirmed by EDX, which shows a strong signal in the metallic iron region at 6–8 Kev. XRD revealed a crystalline nature and an average diameter of 136.43 nm. Antioxidant, anti-inflammatory, cytotoxic, and wound healing in vitro tests reported significant activity of the FeNPs. The cumulative findings of the present study indicate that the green synthesis of FeNPs boosts its biological activity and may serve as a possible dermal wound-healing agent and cytotoxic agent against cancer. Future study is needed on the identification of mechanisms involved in the synthesis of FeNPs by V. leucoxylon and its biomedical applications. Full article

(This article belongs to the Special Issue Advances in Bioactive Nanoparticles on Wound Healing, Tissue Engineering and Drug Delivery)

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Review

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36 pages, 700 KiB

Open AccessReview

The Impressive Anti-Inflammatory Activity of Cerium Oxide Nanoparticles: More than Redox?

by Francesca Corsi, Greta Deidda Tarquini, Marta Urbani, Ignacio Bejarano, Enrico Traversa and Lina Ghibelli

Nanomaterials 2023, 13(20), 2803; https://0-doi-org.brum.beds.ac.uk/10.3390/nano13202803 - 21 Oct 2023

Cited by 3 | Viewed by 1426

Abstract

Cerium oxide nanoparticles (CNPs) are biocompatible nanozymes exerting multifunctional biomimetic activities, including superoxide dismutase (SOD), catalase, glutathione peroxidase, photolyase, and phosphatase. SOD- and catalase-mimesis depend on Ce³⁺/Ce⁴⁺ redox switch on nanoparticle surface, which allows scavenging the most noxious reactive oxygen species in a self-regenerating, energy-free manner. As oxidative stress plays pivotal roles in the pathogenesis of inflammatory disorders, CNPs have recently attracted attention as potential anti-inflammatory agents. A careful survey of the literature reveals that CNPs, alone or as constituents of implants and scaffolds, strongly contrast chronic inflammation (including neurodegenerative and autoimmune diseases, liver steatosis, gastrointestinal disorders), infections, and trauma, thereby ameliorating/restoring organ function. By general consensus, CNPs inhibit inflammation cues while boosting the pro-resolving anti-inflammatory signaling pathways. The mechanism of CNPs’ anti-inflammatory effects has hardly been investigated, being rather deductively attributed to CNP-induced ROS scavenging. However, CNPs are multi-functional nanozymes that exert additional bioactivities independent from the Ce³⁺/Ce⁴⁺ redox switch, such as phosphatase activity, which could conceivably mediate some of the anti-inflammatory effects reported, suggesting that CNPs fight inflammation via pleiotropic actions. Since CNP anti-inflammatory activity is potentially a pharmacological breakthrough, it is important to precisely attribute the described effects to one or another of their nanozyme functions, thus achieving therapeutic credibility. Full article

(This article belongs to the Special Issue Advances in Bioactive Nanoparticles on Wound Healing, Tissue Engineering and Drug Delivery)

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