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Nanomaterials
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Porous Metal-Organic Framework Nanoparticles
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Porous Metal-Organic Framework Nanoparticles

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Inorganic Materials and Metal-Organic Frameworks".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 14154

Special Issue Editors

Prof. Dr. Antonio Vargas-Berenguel

E-Mail Website
Guest Editor
Department of Chemistry and Physics, University of Almeria, 04120 Almeria, Spain
Interests: targeted nanocarriers for therapeutics; sensors for the detection of carbohydrate-lectin interactions; carbohydrates; neoglycoconjugates; glycoside multivalent effect–cyclodextrins: synthesis; supramolecular properties and applications; glycoside nanosystems based on plasmonic nanoparticles and metal organic frameworks
Special Issues, Collections and Topics in MDPI journals
Dr. Juan M. Casas-Solvas

E-Mail Website
Co-Guest Editor
Department of Chemistry and Physics, University of Almeria, Carretera Sacramento S/N, 04120 Almeria, Spain
Interests: targeted drug nanocarriers; cyclodextrins; carbohydrates; multivalency; sensors; electrochemical sensors; nanoparticles; metal-organic frameworks; molecular recognition; binding constants determination
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metal–organic frameworks (MOFs) have attracted a significant amount of interest from researchers in a broad range of scientific disciplines. Their compositional and structural diversity and porous character, with a large surface area to mass ratio and volume, enable them to be used in many applications, including gas storage, catalysis, biomedical, sensing, and energy-related applications. MOF-derived structures at the nanometre scale (NMOFs) can be synthesized by choosing appropriate organic ligands and metal ions and have been shown to enhance the performance of drug nanocarriers and provide gas sensors with high sensitivity. Progress has been made in designing tailored NMOF structures and tuning their morphologies. However, the shaping and engineering of these porous materials remain major challenges and we still need to improve our understanding of the relationship between their performance and morphology.

This Special Issue aims to present an overview of new advances in the preparation and surface engineering of size-controlled nanoscale MOFs. In addition to synthetic aspects, the scope of this Special Issue covers a broad range of applications, including nanomedicine, catalysis, gas storage, and sensors. Contributions in the form of original research articles, review papers, and short communications are welcome.

Prof. Dr. Antonio Vargas-Berenguel
Dr. Juan M. Casas-Solvas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Metal Organic Frameworks
  • Sensors
  • Nanocarriers
  • Catalysis
  • Nanoreactors
  • Drug Delivery
  • Gas storage
  • Functionalized MOFs
  • Nanoparticles
  • Storage
  • Porous materials
  • Removal

Published Papers (4 papers)

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Editorial

Jump to: Research

2 pages, 165 KiB  
Editorial
Porous Metal–Organic Framework Nanoparticles
by Juan M. Casas-Solvas and Antonio Vargas-Berenguel
Nanomaterials 2022, 12(3), 527; https://0-doi-org.brum.beds.ac.uk/10.3390/nano12030527 - 03 Feb 2022
Cited by 3 | Viewed by 1356
Abstract
Metal–organic frameworks (MOFs) are hybrid crystalline particles composed of metal cations and organic linkers [...] Full article
(This article belongs to the Special Issue Porous Metal-Organic Framework Nanoparticles)

Research

Jump to: Editorial

15 pages, 3199 KiB  
Article
Doxorubicin-Loaded Metal-Organic Frameworks Nanoparticles with Engineered Cyclodextrin Coatings: Insights on Drug Location by Solid State NMR Spectroscopy
by Xue Li, Marianna Porcino, Jingwen Qiu, Doru Constantin, Charlotte Martineau-Corcos and Ruxandra Gref
Nanomaterials 2021, 11(4), 945; https://0-doi-org.brum.beds.ac.uk/10.3390/nano11040945 - 08 Apr 2021
Cited by 21 | Viewed by 3292
Abstract
Recently developed, nanoscale metal-organic frameworks (nanoMOFs) functionalized with versatile coatings are drawing special attention in the nanomedicine field. Here we show the preparation of core–shell MIL-100(Al) nanoMOFs for the delivery of the anticancer drug doxorubicin (DOX). DOX was efficiently incorporated in the MOFs [...] Read more.
Recently developed, nanoscale metal-organic frameworks (nanoMOFs) functionalized with versatile coatings are drawing special attention in the nanomedicine field. Here we show the preparation of core–shell MIL-100(Al) nanoMOFs for the delivery of the anticancer drug doxorubicin (DOX). DOX was efficiently incorporated in the MOFs and was released in a progressive manner, depending on the initial loading. Besides, the coatings were made of biodegradable γ-cyclodextrin-citrate oligomers (CD-CO) with affinity for both DOX and the MOF cores. DOX was incorporated and released faster due to its affinity for the coating material. A set of complementary solid state nuclear magnetic resonance (ssNMR) experiments including 1H-1H and 13C-27Al two-dimensional NMR, was used to gain a deep understanding on the multiple interactions involved in the MIL-100(Al) core–shell system. To do so, 13C-labelled shells were synthesized. This study paves the way towards a methodology to assess the nanoMOF component localization at a molecular scale and to investigate the nanoMOF physicochemical properties, which play a main role on their biological applications. Full article
(This article belongs to the Special Issue Porous Metal-Organic Framework Nanoparticles)
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17 pages, 4074 KiB  
Article
Degradation Mechanism of Porous Metal-Organic Frameworks by In Situ Atomic Force Microscopy
by Ioanna Christodoulou, Tom Bourguignon, Xue Li, Gilles Patriarche, Christian Serre, Christian Marlière and Ruxandra Gref
Nanomaterials 2021, 11(3), 722; https://0-doi-org.brum.beds.ac.uk/10.3390/nano11030722 - 13 Mar 2021
Cited by 26 | Viewed by 3743
Abstract
In recent years, Metal-Organic Frameworks (MOFs) have attracted a growing interest for biomedical applications. The design of MOFs should take into consideration the subtle balance between stability and biodegradability. However, only few studies have focused on the MOFs’ stability in physiological media and [...] Read more.
In recent years, Metal-Organic Frameworks (MOFs) have attracted a growing interest for biomedical applications. The design of MOFs should take into consideration the subtle balance between stability and biodegradability. However, only few studies have focused on the MOFs’ stability in physiological media and their degradation mechanism. Here, we investigate the degradation of mesoporous iron (III) carboxylate MOFs, which are among the most employed MOFs for drug delivery, by a set of complementary methods. In situ AFM allowed monitoring with nanoscale resolution the morphological, dimensional, and mechanical properties of a series of MOFs in phosphate buffer saline and in real time. Depending on the synthetic route, the external surface presented either well-defined crystalline planes or initial defects, which influenced the degradation mechanism of the particles. Moreover, MOF stability was investigated under different pH conditions, from acidic to neutral. Interestingly, despite pronounced erosion, especially at neutral pH, the dimensions of the crystals were unchanged. It was revealed that the external surfaces of MOF crystals rapidly respond to in situ changes of the composition of the media they are in contact with. These observations are of a crucial importance for the design of nanosized MOFs for drug delivery applications. Full article
(This article belongs to the Special Issue Porous Metal-Organic Framework Nanoparticles)
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13 pages, 5930 KiB  
Article
Polydopamine-Modified Metal–Organic Frameworks, NH2-Fe-MIL-101, as pH-Sensitive Nanocarriers for Controlled Pesticide Release
by Yongpan Shan, Chunli Xu, Hongjun Zhang, Huiping Chen, Muhammad Bilal, Shujun Niu, Lidong Cao and Qiliang Huang
Nanomaterials 2020, 10(10), 2000; https://0-doi-org.brum.beds.ac.uk/10.3390/nano10102000 - 10 Oct 2020
Cited by 32 | Viewed by 5054
Abstract
Recently, metal–organic frameworks (MOFs) have become a dazzling star among porous materials used in many fields. Considering their intriguing features, MOFs have great prospects for application in the field of sustainable agriculture, especially as versatile pesticide-delivery vehicles. However, the study of MOF-based platforms [...] Read more.
Recently, metal–organic frameworks (MOFs) have become a dazzling star among porous materials used in many fields. Considering their intriguing features, MOFs have great prospects for application in the field of sustainable agriculture, especially as versatile pesticide-delivery vehicles. However, the study of MOF-based platforms for controlled pesticide release has just begun. Controlled pesticide release responsive to environmental stimuli is highly desirable for decreased agrochemical input, improved control efficacy and diminished adverse effects. In this work, simple, octahedral, iron-based MOFs (NH2-Fe-MIL-101) were synthesized through a microwave-assisted solvothermal method using Fe3+ as the node and 2-aminoterephthalic acid as the organic ligand. Diniconazole (Dini), as a model fungicide, was loaded into NH2-Fe-MIL-101 to afford Dini@NH2-Fe-MIL-101 with a satisfactory loading content of 28.1%. The subsequent polydopamine (PDA) modification could endow Dini with pH-sensitive release patterns. The release of Dini from PDA@Dini@NH2-Fe-MIL-101 was much faster in an acidic medium compared to that in neutral and basic media. Moreover, Dini@NH2-Fe-MIL-101 and PDA@Dini@NH2-Fe-MIL-101 displayed good bioactivities against the pathogenic fungus causing wheat head scab (Fusarium graminearum). This research sought to reveal the feasibility of versatile MOFs as a pesticide-delivery platform in sustainable crop protection. Full article
(This article belongs to the Special Issue Porous Metal-Organic Framework Nanoparticles)
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