Nanomaterials

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Dear Colleagues,

The appearance and widespread distribution of nanomaterials of various forms, chemical composition, and charge determined the emergence of a new field of science named nanotoxicology. This field is necessary for improving our understanding of the physicochemical properties of nanomaterials and assessing their toxic effect on humans and the environment. Clinical and experimental studies show that the unique properties of certain nanomaterials can have a negative impact on human cells and tissues and therefore require close attention and unified approaches to assess their safety. Thus, works on assessing the toxic potential of a wide range of nanomaterials using various test systems and modern methodological approaches are relevant. Close attention should also be paid to the evaluation of the use of nanomaterials in the food industry.

Dr. Elvira Rozhina
Guest Editor

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Keywords

toxicity
nanoparticles
nanomaterial properties
risk analysis
in vitro
in vivo
nanotechnology

Published Papers (2 papers)

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Research

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13 pages, 1889 KiB

Open AccessArticle

Features of Copper and Gold Nanoparticle Translocation in Petroselinum crispum Segments

by Alexandra Peshkova, Inga Zinicovscaia, Liliana Cepoi, Ludmila Rudi, Tatiana Chiriac, Nikita Yushin and Alexander Sohatsky

Nanomaterials 2023, 13(11), 1754; https://0-doi-org.brum.beds.ac.uk/10.3390/nano13111754 - 28 May 2023

Cited by 2 | Viewed by 1193

Abstract

The application of metal nanoparticles in industry and medicine results in their release into the environment, which can have a negative impact on human health. The effects of gold (AuNPs) and copper (CuNPs) nanoparticles at the concentration range of 1–200 mg/L on parsley (Petroselinum crispum) under conditions of root exposure and their translocation in roots and leaves were investigated in a 10-day experiment. The content of copper and gold in soil and plant segments was determined using ICP-OES and ICP-MS techniques, while the morphology of nanoparticles was analyzed using transmission electron microscopy. Differences in the nanoparticle uptake and translocation were observed: CuNPs mainly accumulated in soil (4.4–465 mg/kg), while accumulation in the leaves were at the control level. AuNPs mainly accumulated in soil (0.04–108 mg/kg), followed by roots (0.05–45 mg/kg) and leaves (0.16–53 mg/kg). The influence of AuNPs and CuNPs on the biochemical parameters of parsley was on the content of carotenoids, the levels of chlorophyll, and antioxidant activity. Application of CuNPs even at the lowest concentration led to a significant reduction in carotenoids and total chlorophyll content. AuNPs at low concentrations promoted an increase in the content of carotenoids; however, they also significantly reduced it at concentrations higher than 10 mg/L. To our knowledge, this is the first study of the effect of metal nanoparticles on parsley. Full article

(This article belongs to the Special Issue Toxicology and Safety/Risk Assessment of Nanomaterials)

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Review

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13 pages, 1364 KiB

Open AccessReview

Mechanobiological Analysis of Nanoparticle Toxicity

by Abdurazak Aman Ketebo, Shahab Ud Din, Gwang Lee and Sungsu Park

Nanomaterials 2023, 13(10), 1682; https://0-doi-org.brum.beds.ac.uk/10.3390/nano13101682 - 19 May 2023

Cited by 1 | Viewed by 1824

Abstract

Nanoparticles (NPs) are commonly used in healthcare and nanotherapy, but their toxicity at high concentrations is well-known. Recent research has shown that NPs can also cause toxicity at low concentrations, disrupting various cellular functions and leading to altered mechanobiological behavior. While researchers have used different methods to investigate the effects of NPs on cells, including gene expression and cell adhesion assays, the use of mechanobiological tools in this context has been underutilized. This review emphasizes the importance of further exploring the mechanobiological effects of NPs, which could reveal valuable insights into the mechanisms behind NP toxicity. To investigate these effects, different methods, including the use of polydimethylsiloxane (PDMS) pillars to study cell motility, traction force production, and rigidity sensing contractions, have been employed. Understanding how NPs affect cell cytoskeletal functions through mechanobiology could have significant implications, such as developing innovative drug delivery systems and tissue engineering techniques, and could improve the safety of NPs for biomedical applications. In summary, this review highlights the significance of incorporating mechanobiology into the study of NP toxicity and demonstrates the potential of this interdisciplinary field to advance our knowledge and practical use of NPs. Full article

(This article belongs to the Special Issue Toxicology and Safety/Risk Assessment of Nanomaterials)

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