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Nanomaterials
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Nanobiosystems for Complex Diseases
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Nanobiosystems for Complex Diseases

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 15198

Special Issue Editor

Dr. Lide Arana

E-Mail Website
Guest Editor
Applied Chemistry Department, University Basque Country, UPV EHU, Manuel Lardizabal, 3, 20018 Donostia, Spain
Interests: drug delivery systems; solid lipid nanoparticles; nanomedicine; drug targeting; sphingolipids; cell signaling; cell proliferation; cell migration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear colleagues,

Complex diseases are pathological processes triggered by a combination of different factors (related to environment, genetics, lifestyle, or unidentified factors) and are considered the most challenging diseases to treat. Therefore, complex diseases or pathological processes (cancer, neuropathies, multidrug resistance, or antibiotic resistance) require special efforts when it comes to developing efficient therapies. Nonetheless, recent developments in nanotechnology provide encouraging opportunities to design smart strategies for the visualization, diagnosis, or treatment of complex diseases.

This Special Issue will focus on the development of drug delivery systems designed to overcome biological barriers, increase drug efficiency, reduce side effects, improve combined therapy, or enable multitargeting strategies. Therefore, authors working on new therapeutic formulations to treat complex diseases are welcome to submit their contributions to this Special Issue entitled “Nanobiosystems for Complex Diseases”. We are especially interested in drug delivery systems that mimic structural and functional aspects of naturally occurring biological assemblies (cell membrane-based drug delivery systems, exosomes, lipid nanoparticles, liposomes, or micelles) and wish to showcase the most recent papers related to this innovative field.

Dr. Lide Arana
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • smart nanoparticles
  • nanobiosystems
  • lipid nanoparticles
  • biomimetic nanostructures
  • complex diseases
  • cancer
  • neuropathies
  • multidrug resistance
  • antibiotic resistance
  • biological barriers
  • combined therapy
  • multitarget therapy

Published Papers (4 papers)

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Research

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14 pages, 3736 KiB  
Article
Novel Rifampicin and Indocyanine Green Co-Loaded Perfluorocarbon Nanodroplets Provide Effective In Vivo Photo–Chemo–Probiotic Antimicrobility against Pathogen of Acne Vulgaris Cutibacterium acnes
by Kuang-Hung Hsiao, Chun-Ming Huang and Yu-Hsiang Lee
Nanomaterials 2020, 10(6), 1095; https://0-doi-org.brum.beds.ac.uk/10.3390/nano10061095 - 1 Jun 2020
Cited by 5 | Viewed by 3071
Abstract
Acne vulgaris is one of the most prevalent dermatological diseases among adolescents and is often associated with overgrowth of Cutibacterium acnes (C. acnes) in the pilosebaceous units. In this study, we aimed to develop novel rifampicin (RIF) and indocyanine green (ICG) [...] Read more.
Acne vulgaris is one of the most prevalent dermatological diseases among adolescents and is often associated with overgrowth of Cutibacterium acnes (C. acnes) in the pilosebaceous units. In this study, we aimed to develop novel rifampicin (RIF) and indocyanine green (ICG) co-loaded perfluorocarbon nanodroplets named RIPNDs which can simultaneously provide photo-, chemo-, and probiotic-antimicrobility, and explore their efficacy in treatment of C. acnes in vitro and in vivo. The RIPNDs were first characterized as being spherical in shape, with a size of 238.6 ± 7.51 nm and surface charge of −22.3 ± 3.5 mV. Then, the optimal dosages of Staphylococcus epidermidis–produced fermentation product medium (FPM) and RIPND were determined as 25% (v/v) and [RIF]/[ICG] = 3.8/20 μM, respectively, based on the analyses of inhibition zone and cytotoxicity in vitro. Through the in vivo study using C. acnes–inoculated mice, our data showed that the group treated with FPM followed by RIPNDs + near infrared (NIR) irradiation obtained the least granulocytes/macrophage-inflammatory protein 2 expression level in the epidermis, and showed a significantly lower microbial colony population compared to the groups treated with equal amount of RIF, FPM, RIPNDs, and/or combination of the above ± NIR. These results indicated that the RIPND-mediated photo–chemo–probiotic therapeutics was indeed able to rapidly suppress inflammatory response of the skin and provide a robust antibacterial effect against C. acnes with limited use of antibiotics. Taken altogether, we anticipate that the RIPND is highly potential for use in the clinical treatment of acne vulgaris. Full article
(This article belongs to the Special Issue Nanobiosystems for Complex Diseases)
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17 pages, 2583 KiB  
Article
Improving Anticancer Therapy with Naringenin-Loaded Silk Fibroin Nanoparticles
by Marta G. Fuster, Guzmán Carissimi, Mercedes G. Montalbán and Gloria Víllora
Nanomaterials 2020, 10(4), 718; https://0-doi-org.brum.beds.ac.uk/10.3390/nano10040718 - 10 Apr 2020
Cited by 48 | Viewed by 3637
Abstract
Naringenin (NAR), a flavonoid present in a variety of fruits, vegetables and herbs, exhibits a wide range of pharmacological effects, including anticancer activity. Nevertheless, its application in cancer therapy is limited due to its low bioavailability at the tumour site because of its [...] Read more.
Naringenin (NAR), a flavonoid present in a variety of fruits, vegetables and herbs, exhibits a wide range of pharmacological effects, including anticancer activity. Nevertheless, its application in cancer therapy is limited due to its low bioavailability at the tumour site because of its poor solubility in water and slow dissolution rate. To improve the therapeutic efficacy of NAR, emergent research is looking into using nanocarriers. Silk fibroin (SF), from the Bombyx mori silkworm, is a biocompatible and biodegradable polymer with excellent mechanical properties and an amphiphilic chemistry that make it a promising candidate as a controlled release drug system. The aim of this work is to synthesize naringenin-loaded silk fibroin nanoparticles (NAR-SFNs) by dissolving the SF in the ionic liquid 1-ethyl-3-methylimidazolium acetate, using high-power ultrasounds and rapid desolvation in methanol followed by the adsorption of NAR. The NAR-SFNs were characterized by dynamic light scattering, Fourier transform infrared spectroscopy and thermogravimetric analysis. The drug loading content and encapsulation efficiency were calculated. The drug release profile best fitted a first order equation. The cytotoxicity effects of free NAR, bare silk fibroin nanoparticles (SFNs) and NAR-SFNs were assessed on HeLa and EA.hy926 cells via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results demonstrated the higher in vitro anticancer potential of synthesized NAR-SFNs than that of free NAR in HeLa cancer cells. Full article
(This article belongs to the Special Issue Nanobiosystems for Complex Diseases)
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Review

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27 pages, 3407 KiB  
Review
Incorporation of Antibiotics into Solid Lipid Nanoparticles: A Promising Approach to Reduce Antibiotic Resistance Emergence
by Lide Arana, Lucia Gallego and Itziar Alkorta
Nanomaterials 2021, 11(5), 1251; https://0-doi-org.brum.beds.ac.uk/10.3390/nano11051251 - 10 May 2021
Cited by 39 | Viewed by 4436
Abstract
Antimicrobial resistance is one of the biggest threats to global health as current antibiotics are becoming useless against resistant infectious pathogens. Consequently, new antimicrobial strategies are urgently required. Drug delivery systems represent a potential solution to improve current antibiotic properties and reverse resistance [...] Read more.
Antimicrobial resistance is one of the biggest threats to global health as current antibiotics are becoming useless against resistant infectious pathogens. Consequently, new antimicrobial strategies are urgently required. Drug delivery systems represent a potential solution to improve current antibiotic properties and reverse resistance mechanisms. Among different drug delivery systems, solid lipid nanoparticles represent a highly interesting option as they offer many advantages for nontoxic targeted drug delivery. Several publications have demonstrated the capacity of SLNs to significantly improve antibiotic characteristics increasing treatment efficiency. In this review article, antibiotic-loaded solid lipid nanoparticle-related works are analyzed to summarize all information associated with applying these new formulations to tackle the antibiotic resistance problem. The main antimicrobial resistance mechanisms and relevant solid lipid nanoparticle characteristics are presented to later discuss the potential of these nanoparticles to improve current antibiotic treatment characteristics and overcome antimicrobial resistance mechanisms. Moreover, solid lipid nanoparticles also offer new possibilities for other antimicrobial agents that cannot be administrated as free drugs. The advantages and disadvantages of these new formulations are also discussed in this review. Finally, given the progress of the studies carried out to date, future directions are discussed. Full article
(This article belongs to the Special Issue Nanobiosystems for Complex Diseases)
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37 pages, 1699 KiB  
Review
Nanobiosystems for Antimicrobial Drug-Resistant Infections
by Foteini Gkartziou, Nikolaos Giormezis, Iris Spiliopoulou and Sophia G. Antimisiaris
Nanomaterials 2021, 11(5), 1075; https://0-doi-org.brum.beds.ac.uk/10.3390/nano11051075 - 22 Apr 2021
Cited by 13 | Viewed by 3520
Abstract
The worldwide increased bacterial resistance toward antimicrobial therapeutics has led investigators to search for new therapeutic options. Some of the options currently exploited to treat drug-resistant infections include drug-associated nanosystems. Additionally, the use of bacteriophages alone or in combination with drugs has been [...] Read more.
The worldwide increased bacterial resistance toward antimicrobial therapeutics has led investigators to search for new therapeutic options. Some of the options currently exploited to treat drug-resistant infections include drug-associated nanosystems. Additionally, the use of bacteriophages alone or in combination with drugs has been recently revisited; some studies utilizing nanosystems for bacteriophage delivery have been already reported. In this review article, we focus on nine pathogens that are the leading antimicrobial drug-resistant organisms, causing difficult-to-treat infections. For each organism, the bacteriophages and nanosystems developed or used in the last 20 years as potential treatments of pathogen-related infections are discussed. Summarizing conclusions and future perspectives related with the potential of such nano-antimicrobials for the treatment of persistent infections are finally highlighted. Full article
(This article belongs to the Special Issue Nanobiosystems for Complex Diseases)
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