Dear colleagues,

Alzheimer’s disease (AD) is the main contributor to dementia worldwide, a cognitive syndrome that progressively and fatally impairs the ability of the affected individuals to perform essential everyday tasks. Dementia is also the major cause of disability among elderly people worldwide, and its derived social and economic costs are massive. Although the molecular and cellular basis of AD remains a matter of intense scientific investigation and has been partially uncovered, several crucial aspects related to the neuropathology of AD still require our attention and interest. These aspects, although not exhaustive, may involve the following actions: uncovering currently unknown idiopathic triggering factors, shedding light on the molecular mechanisms of neuropathology onset, understanding common neuropathological mechanisms that defy brain cell heterogeneity, identifying potential early-onset biological diagnostic and prognostic markers (neuropathology onset proposed as early as 20 years before clinical diagnosis). Thus, this Special Issue focuses on generating genuine and valuable scientific knowledge on the molecular and cellular basis of AD, with foresight on the apparition of novel diagnosis and therapeutic strategies for this fatal neurological disorder.

You may choose our Joint Special Issue in Biomolecules, or Joint Special Issue in Cells.

Dr. Xavier Gallart-Palau
Dr. Aida Serra
Prof. Dr. Giulio Pasinetti
Dr. Joyce Harary
Guest Editors

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