Herpesvirus Diseases in Humans and Animals

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Viral Pathogens".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 2537

Special Issue Editors


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Guest Editor
Museum of Literature in Moravia, Klášter 1, 664 61 Rajhrad, Czech Republic
Interests: herpesviruses; human herpesvirus infections

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Guest Editor
Department of Applied Ecology, Faculty of Environmental Sciences, Czech University of Life Sciences Prague, Kamýcká 129, 165 00 Prague, Czech Republic
Interests: infectious diseases; pharmacology and toxicology of natural products; analytical methods for isolation and identification of natural products; molecular mechanisms of pharmacological action; pediatric infectious diseases
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Special Issue Information

Dear Colleagues,

Herpesviruses are DNA viruses that infect humans and animals with the ability to induce latent and lytic infections in their hosts, causing critical health complications. There are eight herpesvirus types currently known to infect humans, including Herpes simplex viruses (HSV-1 and HSV-2), varicella-zoster virus, Epstein–Barr virus, human herpesvirus 6 (variants A and B), human herpesvirus 7, Kaposi's sarcoma-associated herpesvirus, and human cytomegalovirus. Besides, animal herpesviruses are responsible for significant economic losses throughout the world. The Herpesviridae family includes herpesviruses that infect vertebrates and invertebrates, and, in veterinary medicine, the herpesviruses of cattle, buffalo, horses, pigs, goats and sheep are important (e.g., equine herpesvirus type 1 (EHV-1), feline herpesvirus, bovine herpesvirus 1, and pseudorabies virus). So, the herpesvirus infection has a variety of clinical forms and is extremely widespread in the world while existing treatment methods are not always quite effective.

For this Special Issue of Pathogens, we invite you to submit either an original research article or an insightful review that addresses the herpesviruses entry, signaling pathways, cell-to-cell spread, replication, pathogenesis, immune evasion, or in vitro models that facilitate studying herpesviruses infection.

Dr. Miroslava Šudomová
Dr. Sherif T. S. Hassan
Guest Editors

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Published Papers (2 papers)

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Editorial

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4 pages, 226 KiB  
Editorial
Herpesvirus Diseases in Humans and Animals: Recent Developments, Challenges, and Charting Future Paths
by Miroslava Šudomová and Sherif T. S. Hassan
Pathogens 2023, 12(12), 1422; https://0-doi-org.brum.beds.ac.uk/10.3390/pathogens12121422 - 07 Dec 2023
Viewed by 924
Abstract
Herpesviruses, a family of enveloped DNA viruses, pose significant threats to both humans and animals [...] Full article
(This article belongs to the Special Issue Herpesvirus Diseases in Humans and Animals)

Research

Jump to: Editorial

14 pages, 1242 KiB  
Article
Ovine Herpesvirus 2 Glycoprotein B Complementation Restores Infectivity to a Bovine Herpesvirus 4 gB-Null Mutant
by Daniela D. Moré, Katherine N. Baker, Smriti Shringi, Reginaldo G. Bastos, Donal O’Toole, Gaetano Donofrio and Cristina W. Cunha
Pathogens 2024, 13(3), 219; https://0-doi-org.brum.beds.ac.uk/10.3390/pathogens13030219 - 01 Mar 2024
Viewed by 1131
Abstract
Ovine herpesvirus 2 (OvHV-2) and bovine herpesvirus 4 (BoHV-4) are gamma herpesviruses that belong to the genera Macavirus and Rhadinovirus, respectively. As with all herpesviruses, both OvHV-2 and BoHV-4 express glycoprotein B (gB), which plays an essential role in the infection of [...] Read more.
Ovine herpesvirus 2 (OvHV-2) and bovine herpesvirus 4 (BoHV-4) are gamma herpesviruses that belong to the genera Macavirus and Rhadinovirus, respectively. As with all herpesviruses, both OvHV-2 and BoHV-4 express glycoprotein B (gB), which plays an essential role in the infection of host cells. In that context, it has been demonstrated that a BoHV-4 gB-null mutant is unable to infect host cells. In this study, we used homologous recombination to insert OvHV-2 ORF 8, encoding gB, into the BoHV-4 gB-null mutant genome, creating a chimeric BoHV-4 virus carrying and expressing OvHV-2 gB (BoHV-4∆gB/OvHV-2-gB) that was infectious and able to replicate in vitro. We then evaluated BoHV-4∆gB/OvHV-2-gB as a potential vaccine candidate for sheep-associated malignant catarrhal fever (SA-MCF), a fatal disease of ungulates caused by OvHV-2. Using rabbits as a laboratory model for MCF, we assessed the safety, immunogenicity, and efficacy of BoHV-4∆gB/OvHV-2-gB in an immunization/challenge trial. The results showed that while BoHV-4∆gB/OvHV-2-gB was safe and induced OvHV-2 gB-specific humoral immune responses, immunization conferred only 28.5% protection upon challenge with OvHV-2. Therefore, future studies should focus on alternative strategies to express OvHV-2 proteins to develop an effective vaccine against SA-MCF. Full article
(This article belongs to the Special Issue Herpesvirus Diseases in Humans and Animals)
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