Molecular Pathogenesis and Vaccine Development of Porcine Virus Infection

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Vaccines and Therapeutic Developments".

Deadline for manuscript submissions: 20 May 2024 | Viewed by 3308

Special Issue Editors


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Guest Editor
School of Veterinary Medicine, National Taiwan University, No.1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan
Interests: pestiviruses; virulence; pathogenesis; viral glycoprotein structure and function; epitope mapping
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
School of Veterinary Medicine, National Taiwan University, No.1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan
Interests: veterinary pathology; diagnostic pathology; pathogenesis of viral diseases and of swine diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, more and more endemic and emerging porcine viral diseases have spread throughout the world, causing huge economic impact on swine production. Important porcine viral diseases include African swine fever (ASF), classical swine fever (CSF), foot and mouth disease (FMD), porcine epidemic diarrhea (PED), porcine reproductive and respiratory syndrome (PRRS), and porcine circovirus associated disease (PCVAD). Vaccines are available against several porcine viral diseases, such as CSF, FMD, PRRS, and PCV2, but there is no officially licensed vaccine available for ASF. This Special Issue of Pathogens will focus on the Molecular Pathogenesis and Vaccine Development of Porcine Viral Diseases. After experiencing the impact of these viral diseases in the form of the COVID-19 pandemic, it has become clear that a precise understanding of viral pathogenesis lays a solid foundation for the development of efficacious vaccines. Thus, the two issues of molecular pathogenesis and vaccine development are in fact one.

Suggested topics for including in this Special Issue include, but are not limited to, pathogenesis in vitro and in vivo, virulence factors, host immune response, identification of potential viral antigens, new techniques for vaccine development and production, and the development of DIVA vaccines. We would like to cordially invite you to contribute your papers to this Special Issue. There is no limitation on the types of contributions; original articles, brief communications, case reports, and reviews are welcome. Your valuable input will enrich the current state of knowledge and contribute to the disease control of porcine virus infections.

Dr. Chia-Yi Chang
Prof. Dr. Fun-In Wang
Guest Editors

Manuscript Submission Information

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Keywords

  • pathogenesis
  • virulence
  • immune response
  • vaccine development
  • porcine virus

Published Papers (1 paper)

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Review

18 pages, 3288 KiB  
Review
The Effects of Swine Coronaviruses on ER Stress, Autophagy, Apoptosis, and Alterations in Cell Morphology
by Ya-Mei Chen and Eric Burrough
Pathogens 2022, 11(8), 940; https://0-doi-org.brum.beds.ac.uk/10.3390/pathogens11080940 - 19 Aug 2022
Cited by 6 | Viewed by 2852
Abstract
Swine coronaviruses include the following six members, namely porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), porcine delta coronavirus (PDCoV), swine acute diarrhea syndrome coronavirus (SADS-CoV), porcine hemagglutinating encephalomyelitis virus (PHEV), and porcine respiratory coronavirus (PRCV). Clinically, PEDV, TGEV, PDCoV, and SADS-CoV [...] Read more.
Swine coronaviruses include the following six members, namely porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), porcine delta coronavirus (PDCoV), swine acute diarrhea syndrome coronavirus (SADS-CoV), porcine hemagglutinating encephalomyelitis virus (PHEV), and porcine respiratory coronavirus (PRCV). Clinically, PEDV, TGEV, PDCoV, and SADS-CoV cause enteritis, whereas PHEV induces encephalomyelitis, and PRCV causes respiratory disease. Years of studies reveal that swine coronaviruses replicate in the cellular cytoplasm exerting a wide variety of effects on cells. Some of these effects are particularly pertinent to cell pathology, including endoplasmic reticulum (ER) stress, unfolded protein response (UPR), autophagy, and apoptosis. In addition, swine coronaviruses are able to induce cellular changes, such as cytoskeletal rearrangement, alterations of junctional complexes, and epithelial-mesenchymal transition (EMT), that render enterocytes unable to absorb nutrients normally, resulting in the loss of water, ions, and protein into the intestinal lumen. This review aims to describe the cellular changes in swine coronavirus-infected cells and to aid in understanding the pathogenesis of swine coronavirus infections. This review also explores how the virus exerted subcellular and molecular changes culminating in the clinical and pathological findings observed in the field. Full article
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