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Pathogens
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The Parasitic Schistosome Worm and Schistosomiasis
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The Parasitic Schistosome Worm and Schistosomiasis

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Parasitic Pathogens".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 3321

Special Issue Editor

Dr. Emmitt R. Jolly

E-Mail Website
Guest Editor
Department of Biology, School of Arts and Sciences, Global Health and Diseases, Division of General Medical Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Interests: schistosome; parasitic schistosome worm; schistosomiasis

Special Issue Information

Dear Colleagues,

The journal Pathogens (impact factor: 3.018) is running a Special Issue broadly on "Schistosomes", and Prof. Dr. Emmitt R Jolly (Case Western Reserve University, USA) is serving as Guest Editor. We invite you to submit an exciting original research article or review focused on schistosome biology, -omics, or host interaction for potential publication in this Special Issue. Based on your expertise in the field, we think you could make an excellent contribution to Pathogens. We look forward to hearing from you.

Dr. Emmitt R. Jolly
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Schistosoma
  • Development
  • Gene regulation
  • Helminth
  • schistosomiasis
  • proteomics
  • transcriptome
  • transfection
  • host invasion
  • host evasion
  • sporocyst
  • miracidia
  • schistosomula
  • tool development

Published Papers (2 papers)

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Research

17 pages, 2835 KiB  
Article
Characterization of Schistosome Sox Genes and Identification of a Flatworm Class of Sox Regulators
by Stephanie Wood, Kenji Ishida, James R. Hagerty, Anida Karahodza, Janay N. Dennis and Emmitt R. Jolly
Pathogens 2023, 12(5), 690; https://0-doi-org.brum.beds.ac.uk/10.3390/pathogens12050690 - 09 May 2023
Viewed by 1475
Abstract
Schistosome helminths infect over 200 million people across 78 countries and are responsible for nearly 300,000 deaths annually. However, our understanding of basic genetic pathways crucial for schistosome development is limited. The sex determining region Y-box 2 (Sox2) protein is a Sox B [...] Read more.
Schistosome helminths infect over 200 million people across 78 countries and are responsible for nearly 300,000 deaths annually. However, our understanding of basic genetic pathways crucial for schistosome development is limited. The sex determining region Y-box 2 (Sox2) protein is a Sox B type transcriptional activator that is expressed prior to blastulation in mammals and is necessary for embryogenesis. Sox expression is associated with pluripotency and stem cells, neuronal differentiation, gut development, and cancer. Schistosomes express a Sox-like gene expressed in the schistosomula after infecting a mammalian host when schistosomes have about 900 cells. Here, we characterized and named this Sox-like gene SmSOXS1. SmSoxS1 protein is a developmentally regulated activator that localizes to the anterior and posterior ends of the schistosomula and binds to Sox-specific DNA elements. In addition to SmSoxS1, we have also identified an additional six Sox genes in schistosomes, two Sox B, one SoxC, and three Sox genes that may establish a flatworm-specific class of Sox genes with planarians. These data identify novel Sox genes in schistosomes to expand the potential functional roles for Sox2 and may provide interesting insights into early multicellular development of flatworms. Full article
(This article belongs to the Special Issue The Parasitic Schistosome Worm and Schistosomiasis)
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10 pages, 257 KiB  
Article
Predicting the Occurrence of Advanced Schistosomiasis Based on FISHER Discriminant Analysis of Hematological Biomarkers
by Fei Hu, Fan Yang, Huiqun Xie, Zhulu Gao, Jing Xu, An Ning and Shuying Xie
Pathogens 2022, 11(9), 1004; https://0-doi-org.brum.beds.ac.uk/10.3390/pathogens11091004 - 03 Sep 2022
Viewed by 1168
Abstract
We established a model that predicts the possibility of chronic schistosomiasis (CS) patients developing into advanced schistosomiasis (AS) patients using special biomarkers that were detected in human peripheral blood. Blood biomarkers from two cohorts (132 CS cases and 139 AS cases) were examined [...] Read more.
We established a model that predicts the possibility of chronic schistosomiasis (CS) patients developing into advanced schistosomiasis (AS) patients using special biomarkers that were detected in human peripheral blood. Blood biomarkers from two cohorts (132 CS cases and 139 AS cases) were examined and data were collected and analyzed by univariate and multivariate logistic regression analysis. Fisher discriminant analysis (FDA) for advanced schistosomiasis was established based on specific predictive diagnostic indicators and its accuracy was assessed using data of 109 CS. The results showed that seven indicators including HGB, MON, GLB, GGT, APTT, VIII, and Fbg match the model. The accuracy of the FDA was assessed by cross-validation, and 86.7% of the participants were correctly classified into AS and CS groups. Blood biomarker data from 109 CS patients were converted into the discriminant function to determine the possibility of occurrence of AS. The results demonstrated that the possibility of occurrence of AS and CS was 62.1% and 89.0%, respectively, and the accuracy of the established model was 81.4%. Evidence displayed that Fisher discriminant analysis is a reliable predictive model in the clinical field. It’s an important guide to effectively control the occurrence of AS and lay a solid foundation for achieving the goal of schistosomiasis elimination. Full article
(This article belongs to the Special Issue The Parasitic Schistosome Worm and Schistosomiasis)
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