Special Issue "Arsenic Toxicity"

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Toxicology".

Deadline for manuscript submissions: closed (28 February 2019).

Special Issue Editors

Prof. Dr. Judit Smits
E-Mail Website
Guest Editor
Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada
Interests: avian immunotoxicology; ecotoxicology; reducing chronic arsenic poisoning in humans through a dietary approach; wildlife toxicology; wildlife sentinels of ecosystem health
Dr. Rubhana Raqib
E-Mail
Guest Editor
International Center for Diarrheal Disease Research, Dhaka, 1000, Bangladesh

Special Issue Information

Dear Colleagues,

Arsenic has been a pesticide, a poison, and a medicine since ancient times with descriptions of its use noted from before the Ming Dynsasty to the 20th century. As populations grow and become more concentrated, expanding pressures on water resources, arsenic increasingly enters groundwater systems from leaching and weathering of minerals, soil and rock.  Arsenic in drinking water is just one aspect of the United Nations Sustainable Development Goals for 2030, which specifies achieving universal access to clean water as the third of its six goals.

Currently, about 100 million people worldwide are exposed to high levels of arsenic through their water and food.  South Asia, Inner Mongolia, Pakistan and Taiwan have been long recognized to have serious problems from chronic arsenic exposure in humans.  However, Argentina, Chile, Mexico, Germany, Spain, Italy, parts of United States, plus numerous other areas, are being identified to have high arsenic exposure of humans through food and water.

There is a wide range of research into problems leading to, or caused by chronic arsenic poisoning.  Geologists and geochemists have examined mechanisms contributing to the unpredictable spatial variation of arsenic contamination in ground water. The movement of arsenic through terrestrial and aquatic environments, and its toxicity to vertebrates is largely driven by its speciation.  Biochemical and gene-based studies examine physiological factors responsible for biotransformation and detoxification of arsenic.  The wide-ranging health effects from chronic arsenic exposure are of major medical interest. Skin lesions and neoplasias have well established dose-response relationships with chronic arsenic exposure at lower levels than originally thought. Long-term studies consistently show cardiovascular disease and atherosclerosis to have temporal and dose-related relationships with arsenic. 

This Special Issue is devoted to highlighting current research around the world, into the growing problem of arsenicosis in people with unacceptable levels of arsenic in their water and food.

Prof. Dr. Judit Smits
Dr. Rubhana Raqib
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • arsenic toxicity
  • adverse health effects
  • mitigating chronic arsenic toxicity
  • selenium antagonism of arsenic
  • clinical trial
  • arsenic-induced atherosclerosis

Published Papers (1 paper)

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Review

Review
Antioxidants Protect against Arsenic Induced Mitochondrial Cardio-Toxicity
Toxics 2017, 5(4), 38; https://0-doi-org.brum.beds.ac.uk/10.3390/toxics5040038 - 05 Dec 2017
Cited by 21 | Viewed by 2892
Abstract
Arsenic is a potent cardiovascular toxicant associated with numerous biomarkers of cardiovascular diseases in exposed human populations. Arsenic is also a carcinogen, yet arsenic trioxide is used as a therapeutic agent in the treatment of acute promyelotic leukemia (APL). The therapeutic use of [...] Read more.
Arsenic is a potent cardiovascular toxicant associated with numerous biomarkers of cardiovascular diseases in exposed human populations. Arsenic is also a carcinogen, yet arsenic trioxide is used as a therapeutic agent in the treatment of acute promyelotic leukemia (APL). The therapeutic use of arsenic is limited due to its severe cardiovascular side effects. Many of the toxic effects of arsenic are mediated by mitochondrial dysfunction and related to arsenic’s effect on oxidative stress. Therefore, we investigated the effectiveness of antioxidants against arsenic induced cardiovascular dysfunction. A growing body of evidence suggests that antioxidant phytonutrients may ameliorate the toxic effects of arsenic on mitochondria by scavenging free radicals. This review identifies 21 antioxidants that can effectively reverse mitochondrial dysfunction and oxidative stress in cardiovascular cells and tissues. In addition, we propose that antioxidants have the potential to improve the cardiovascular health of millions of people chronically exposed to elevated arsenic concentrations through contaminated water supplies or used to treat certain types of leukemias. Importantly, we identify conceptual gaps in research and development of new mito-protective antioxidants and suggest avenues for future research to improve bioavailability of antioxidants and distribution to target tissues in order reduce arsenic-induced cardiovascular toxicity in a real-world context. Full article
(This article belongs to the Special Issue Arsenic Toxicity)
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