Endocrine Disruptors Exposure, Health Risk Assessment and Human Biomonitoring

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Exposome Analysis and Risk Assessment".

Deadline for manuscript submissions: closed (15 August 2023) | Viewed by 1593

Special Issue Editor


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Guest Editor
Environmental Engineering Laboratory, Department of Chemical Engineering, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: environmental/atmospheric process modeling; advanced human exposure science; health impact assessment of environmental stressors; neural computation

Special Issue Information

Dear Colleagues,

EDCs are defined as exogenous substances resulting in perturbations of the endocrine system and consequently cause adverse health effects in an intact organism, or its progeny, or in (sub)populations. Exposure to EDCs is especially hazardous during certain periods of development (susceptibility windows) and has a strong influence on health throughout the whole life course. Given the above, there is a need to strengthen knowledge about EDCs in mixtures and alone; to improve methods of testing that enable the identification of EDCs; to find the most effective ways of reducing exposure and, thereby, vulnerability to disease; to collect data from areas that have not been sufficiently surveyed; to create environments that promote and enable scientific progress, innovation, and disease prevention; and to promote research aimed at better understanding exposure to EDCs and their relation to adverse health outcomes. Based on the above, a better understanding of both exposure to EDCs (using both bottom-up estimates and assimilation of human biomonitoring data), as well the health effects posed by EDCs is necessary. In this sense, manuscripts that provide new knowledge on advanced exposure and health risk assessment (e.g., NAMs, omics, systems biology models, AOPs) are more than welcomed in this Special Issue.

Dr. Spyros Karakitsios
Guest Editor

Manuscript Submission Information

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Keywords

  • EDCs
  • exposure
  • mixtures
  • NAMs
  • omics
  • AOPs
  • health effects
  • risk assessment

Published Papers (1 paper)

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Research

17 pages, 3100 KiB  
Article
Untargeted Metabolomics Analysis Reveals Toxicity Based on the Sex and Sexual Maturity of Single Low-Dose DEHP Exposure
by Hyeon-Jeong Lee, Jonghwa Jin, Yoondam Seo, Inseon Kang, Junghyun Son, Eugene C. Yi and Hophil Min
Toxics 2023, 11(9), 794; https://0-doi-org.brum.beds.ac.uk/10.3390/toxics11090794 - 20 Sep 2023
Cited by 1 | Viewed by 1305
Abstract
Di-(2-Ethylhexyl) phthalate (DEHP) is a prevalent environmental endocrine disruptor that affects homeostasis, reproduction, and developmental processes. The effects of DEHP have been shown to differ based on sex and sexual maturity. This study examines the metabolic profiles of mature adult rats from both [...] Read more.
Di-(2-Ethylhexyl) phthalate (DEHP) is a prevalent environmental endocrine disruptor that affects homeostasis, reproduction, and developmental processes. The effects of DEHP have been shown to differ based on sex and sexual maturity. This study examines the metabolic profiles of mature adult rats from both sexes, aged 10 weeks, and adolescent female rats, aged 6 weeks, following a single 5 mg/kg of body weight DEHP oral administration. An untargeted metabolomic analysis was conducted on urine samples collected at multiple times to discern potential sex- and maturity-specific DEHP toxicities. Various multivariate statistical analyses were employed to identify the relevant metabolites. The findings revealed disruptions to the steroid hormone and primary bile acid biosynthesis. Notably, DEHP exposure increased hyocholic, muricholic, and ketodeoxycholic acids in male rats. Moreover, DEHP exposure was linked to heart, liver, and kidney damage, as indicated by increased plasma GOT1 levels when compared to the levels before DEHP exposure. This study provides detailed insights into the unique mechanisms triggered by DEHP exposure concerning sex and sexual maturity, emphasizing significant distinctions in lipid metabolic profiles across the different groups. This study results deepens our understanding of the health risks linked to DEHP, informing future risk assessments and policy decisions. Full article
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