Special Issue "Pore-Forming Toxin Interactions with the Membrane"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".

Deadline for manuscript submissions: 31 March 2022.

Special Issue Editor

Dr. Peter A. Keyel
E-Mail Website
Guest Editor
Department of Biological Sciences, Texas Tech University, Box 43131 Lubbock, TX 79409, USA
Interests: cholesterol-dependent cytolysin; membrane repair; inflammasome; macrophage; Dnase1L3
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Pore-forming toxins (PFTs) are used both to promote host defense and as key bacterial virulence factors. They disrupt lipid membranes and are difficult to target therapeutically. Understanding how PFTs engage with the membrane is critical to learning how to effectively target PFTs for therapy. While considerable progress has been made in this area, there remain key unknowns in several aspects of PFT–membrane biology. For example, how do PFTs target the membrane? What structural changes and regulatory factors are needed to recruit PFTs to the membrane? How does membrane composition impact PFT binding, oligomerization, and pore formation? How and what signals are generated by PFT interactions with the membrane and receptors? What commonalities exist between PFTs from different classes and/or organisms?

This Special Issue will focus on the interaction of pore-forming toxins with cell membranes, the functional outcomes of these interactions, and membrane responses to these toxins. Nonlethal toxin–membrane interactions, and novel insights into membrane organization, are areas of especial interest.

Dr. Peter A. Keyel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • pore-forming toxin
  • cholesterol-dependent cytolysin
  • hemolysin
  • plasma membrane
  • host–pathogen interaction
  • membrane repair
  • cell death
  • phase transition

Published Papers

This special issue is now open for submission.
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