Special Issue "Clostridioides difficile Toxins and Virulence Factors"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".

Deadline for manuscript submissions: 31 January 2022.

Special Issue Editor

Prof. Dr. Charles Darkoh
E-Mail Website
Guest Editor
Center for Infectious Diseases, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston.

Special Issue Information

Clostridioides (formerly Clostridium difficile) infection (CDI) is a major public health problem worldwide. CDI incidence rates are increasing at an alarming rate, with the total cost of treatment estimated to be up to 7 billion US dollars annually. C. difficile is responsible for 10%–25% of cases of antibiotic-associated diarrhea, 50%–75% of antibiotic-associated colitis, and 90%–100% of pseudomembranous colitis. Morbidity and mortality resulting from CDI-associated diseases have also increased significantly over the past ten years, making C. difficile one of the most important emerging antibiotic-associated diarrheagenic pathogens in the world. As a result, the U. S. Centers for Disease Control and Prevention has designated C. difficile as an urgent threat. The risk for CDI increases with broad-spectrum antibiotics use, which disrupts the native gut microbiota, allowing C. difficile to proliferate. Other CDI-associated risk factors include old age, use of gastric acid-suppressing drugs, comorbidities, immunodeficiency, and inflammatory bowel disease. C. difficile virulence is largely dependent on the production of the toxins which are directly responsible for the disease. This Special Issue will cover recent findings on C. difficile toxins, as well as important virulence factors involved in its pathogenesis.

Prof. Dr. Charles Darkoh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Clostridium difficile pathogenesis
  • Clostridium toxins A and A
  • Clostridium binary toxins
  • virulence factors of Clostridium
  • toxin regulation

Published Papers

This special issue is now open for submission.
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