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Vision
Special Issues
The Ocular Microbiome
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The Ocular Microbiome

A special issue of Vision (ISSN 2411-5150).

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 3866

Special Issue Editors

Prof. Dr. Darlene Miller

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Guest Editor
1. Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA
2. Ocular Microbiology Laboratory, Anne Bates Leach Eye Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, McKnight Research Pavilions, Rm 103A,1638 NW 10th Avenue, Miami, FL 33136, USA
3. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, USA
Interests: ophthalmology; ocular microbiology; keratitis; ocular infectious diseases
Special Issues, Collections and Topics in MDPI journals
Dr. Kara Cavuoto

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Guest Editor
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 NW 17th Street, Miami, FL 33136, USA
Interests: ocular infections; conjunctivitis; keratitis; ocular surface microbiome; adults; children
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Background: The ocular surface microbiome is a complex network of microorganisms that live on the surface of the eye. Studies have shown that the microbiome is not only composed of bacteria, but also viruses, fungi and rarely protozoa. Various factors can influence these organisms, including ocular surface health, aging, contact lens wear, medications, infections and ocular surgery. Additionally, the interplay between these microorganisms, the ocular surface and invading pathogens may have important roles in disease pathophysiology.

Goal: Basic and translational research on the ocular surface microbiome, the interspecies and intraspecies interactions and host response is required in order to elucidate their roles in the health and disease of the eye.

Scope: This Special Issue will feature the diversity of the ocular surface microbial community, their interactions and impact on ocular surface homeostasis.  Authors are invited to submit original basic and translational research articles or reviews.

The conjunct Special Issue in Microorganisms: The Ocular Microbiome

Prof. Dr. Darlene Miller
Dr. Kara Cavuoto
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vision is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (1 paper)

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Research

12 pages, 1188 KiB  
Article
Ocular Surface Microbiota in Contact Lens Users and Contact-Lens-Associated Bacterial Keratitis
by Jasmine Andersson, Josef K. Vogt, Marlene D. Dalgaard, Oluf Pedersen, Kim Holmgaard and Steffen Heegaard
Vision 2021, 5(2), 27; https://0-doi-org.brum.beds.ac.uk/10.3390/vision5020027 - 03 Jun 2021
Cited by 12 | Viewed by 3104
Abstract
Our objectives were to investigate whether the conjunctival microbiota is altered by contact lens wear and/or bacterial keratitis and to explore the hypothesis that commensals of conjunctival microbiota contribute to bacterial keratitis. Swab samples from both eyes were collected separately from the inferior [...] Read more.
Our objectives were to investigate whether the conjunctival microbiota is altered by contact lens wear and/or bacterial keratitis and to explore the hypothesis that commensals of conjunctival microbiota contribute to bacterial keratitis. Swab samples from both eyes were collected separately from the inferior fornix of the conjunctiva of non-contact-lens users (nparticipants = 28) and contact lens users (nparticipants = 26) and from patients with contact-lens-associated bacterial keratitis (nparticipants = 9). DNA from conjunctival swab samples was analyzed with 16S rRNA gene amplicon sequencing. Pathogens from the corneal infiltrates were identified by cultivation. In total, we identified 19 phyla and 283 genera; the four most abundant genera were Pseudomonas, Enhydrobacter, Staphylococcus, and Cutibacterium. Several pathogens related to bacterial keratitis were identified in the conjunctival microbiota of the whole study population, and the same bacteria were identified by both methods in the conjunctiva and cornea for four patients with contact-lens-associated bacterial keratitis. The overall conjunctival microbiota profile was not altered by contact lens wear or bacterial keratitis; thus, it does not appear to contribute to the development of bacterial keratitis in contact lens users. However, in some individuals, conjunctival microbiota may harbor opportunistic pathogens causing contact-lens-associated bacterial keratitis. Full article
(This article belongs to the Special Issue The Ocular Microbiome)
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