Extracorporeal Membrane Oxygenation (ECMO)

Topic Information

Dear Colleagues,

During the last decades, extracorporeal membrane oxygenation (ECMO) has been used to describe the use of extracorporeal cardiopulmonary support in the ICU. Over the years the use of ECMO has expanded from neonates to adults and consists of pulmonary, cardiac, or combined support. Initially ECMO was applied when patients were on maximal conventional support and were considered to be moribund. The initial results in the neonatal population showed a mortality reduction from the predicted greater than 90% risk of mortality to a greater than 50% survival rate. In 1989 the Extracorporeal Life Support Organization (ELSO) was voluntarily formed to pool data and knowledge from all active ECMO centers.

Our Topic, together with the journals (Journal of Cardiovascular Development and Disease, Journal of Clinical Medicine, Medicina, Membranes, Advances in Respiratory Medicine) provide a platform for researchers around the globe to share the novel and cutting-edge works about extracorporeal membrane oxygenation. Topics include, but are not limited to, the following: extracorporeal CO₂ removal, extracorporeal life support, membrane biocompatibility, ECMO transportation, anticoagulation strategies, membrane imaging. Authors are invited to submit their latest results: original research papers, reviews (narrative, systematic), or case reports are welcome.

Prof. Dr. Patrick Honore
Prof. Dr. Isabelle Michaux
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Journal of Cardiovascular Development and Disease jcdd	2.4	2.4	2014	20.3 Days	CHF 2700	Submit
Journal of Clinical Medicine jcm	3.9	5.4	2012	17.9 Days	CHF 2600	Submit
Medicina medicina	2.6	3.6	1920	19.6 Days	CHF 1800	Submit
Membranes membranes	4.2	4.4	2011	13.6 Days	CHF 2700	Submit
Advances in Respiratory Medicine arm	1.8	2.0	1909	25.9 Days	CHF 1300	Submit

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Published Papers (2 papers)

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11 pages, 2945 KiB  

Open AccessArticle

Has Extracorporeal Gas Exchange Performance Reached Its Peak?

by Foivos Leonidas Mouzakis, Ali Kashefi, Flutura Hima, Khosrow Mottaghy and Jan Spillner

Membranes 2024, 14(3), 68; https://0-doi-org.brum.beds.ac.uk/10.3390/membranes14030068 - 17 Mar 2024

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Abstract

Extracorporeal gas exchange therapies evolved considerably within the first three–four decades of their appearance, and have since reached a mature stage, where minor alterations and discrete fine-tuning might offer some incremental improvement. A different approach is introduced here, making use of modern, purely [...] Read more.

Extracorporeal gas exchange therapies evolved considerably within the first three–four decades of their appearance, and have since reached a mature stage, where minor alterations and discrete fine-tuning might offer some incremental improvement. A different approach is introduced here, making use of modern, purely diffusive membrane materials, and taking advantage of the elevated concentration gradient ensuing from gas pressure buildup in the gas chamber of the oxygenator. An assortment of silicone membrane gas exchangers were tested in vitro as per a modified protocol in pursuance of assessing their gas exchange efficiency under both regular and high-pressure aeration conditions. The findings point to a stark performance gain when pressurization of the gas compartment is involved; a 40% rise above atmospheric pressure elevates oxygen transfer rate (OTR) by nearly 30%. Carbon dioxide transfer rate (CTR) does not benefit as much from this principle, yet it retains a competitive edge when higher gas flow/blood flow ratios are employed. Moreover, implementation of purely diffusive membranes warrants a bubble-free circulation. Further optimization of the introduced method ought to pave the way for in vivo animal trials, which in turn may potentially unveil new realms of gas exchange performance for therapies associated with extracorporeal circulation. Full article

(This article belongs to the Topic Extracorporeal Membrane Oxygenation (ECMO))

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11 pages, 1271 KiB  

Open AccessArticle

Severe Lung Dysfunction and Pulmonary Blood Flow during Extracorporeal Membrane Oxygenation

by Lars Falk, Marika Lidegran, Sandra Diaz Ruiz, Jan Hultman and Lars Mikael Broman

J. Clin. Med. 2024, 13(4), 1113; https://0-doi-org.brum.beds.ac.uk/10.3390/jcm13041113 - 16 Feb 2024

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Abstract

Background: Extracorporeal membrane oxygenation (ECMO) is indicated for patients with severe respiratory and/or circulatory failure. The standard technique to visualize the extent of pulmonary damage during ECMO is computed tomography (CT). Purpose: This single-center, retrospective study investigated whether pulmonary blood flow (PBF) measured [...] Read more.

Background: Extracorporeal membrane oxygenation (ECMO) is indicated for patients with severe respiratory and/or circulatory failure. The standard technique to visualize the extent of pulmonary damage during ECMO is computed tomography (CT). Purpose: This single-center, retrospective study investigated whether pulmonary blood flow (PBF) measured with echocardiography can assist in assessing the extent of pulmonary damage and whether echocardiography and CT findings are associated with patient outcomes. Methods: All patients (>15 years) commenced on ECMO between 2011 and 2017 with septic shock of pulmonary origin and a treatment time >28 days were screened. Of 277 eligible patients, 9 were identified where both CT and echocardiography had been consecutively performed. Results: CT failed to indicate any differences in viable lung parenchyma within or between survivors and non-survivors at any time during ECMO treatment. Upon initiation of ECMO, the survivors (n = 5) and non-survivors (n = 4) had similar PBF. During a full course of ECMO support, survivors showed no change in PBF (3.8 ± 2.1 at ECMO start vs. 7.9 ± 4.3 L/min, p = 0.12), whereas non-survivors significantly deteriorated in PBF from 3.5 ± 1.0 to 1.0 ± 1.1 L/min (p = 0.029). Tidal volumes were significantly lower over time among the non-survivors, p = 0.047. Conclusions: In prolonged ECMO for pulmonary septic shock, CT was not found to be effective for the evaluation of pulmonary viability or recovery. This hypothesis-generating investigation supports echocardiography as a tool to predict pulmonary recovery via the assessment of PBF at the early to later stages of ECMO support. Full article

(This article belongs to the Topic Extracorporeal Membrane Oxygenation (ECMO))

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