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One-Electron Reduction of Penicillins in Relation to the Oxidative Stress Phenomenon

1
Institute for Energy Security and Environmental Safety, Centre for Energy Research, Hungarian Academy of Sciences, Budapest H-1121, Hungary
2
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest H-1111, Hungary
3
Óbuda University, Sándor Rejtő Faculty of Light Industry and Environmental Engineering, Budapest H-1034, Hungary
*
Author to whom correspondence should be addressed.
Academic Editor: Malcolm D´Souza
Int. J. Mol. Sci. 2015, 16(12), 29673-29681; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms161226130
Received: 29 September 2015 / Revised: 9 November 2015 / Accepted: 11 November 2015 / Published: 11 December 2015
(This article belongs to the Special Issue Solution Chemical Kinetics)
Certain bactericidal antibiotics target mitochondrial components and, due to the leakage of electrons from the electron transport chain, one-electron reduction might occur that can lead to intermediates passing the electron to suitable acceptors. This study aimed at investigating the one-electron reduction mechanism of selected penicillin derivatives using pulse radiolysis techniques. Penicillins can accommodate the electron on each of their carbonyl carbon. Ketyl radicals are thus produced, which are reducing agents with possibility to interact with suitable biomolecules. A detailed mechanism of the reduction is reported. View Full-Text
Keywords: antibiotic; penicillin; oxidative stress; reactive oxygen species; reduction; hydrated electron; ketyl radical; pulse radiolysis antibiotic; penicillin; oxidative stress; reactive oxygen species; reduction; hydrated electron; ketyl radical; pulse radiolysis
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MDPI and ACS Style

Szabó, L.; Tóth, T.; Takács, E.; Wojnárovits, L. One-Electron Reduction of Penicillins in Relation to the Oxidative Stress Phenomenon. Int. J. Mol. Sci. 2015, 16, 29673-29681. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms161226130

AMA Style

Szabó L, Tóth T, Takács E, Wojnárovits L. One-Electron Reduction of Penicillins in Relation to the Oxidative Stress Phenomenon. International Journal of Molecular Sciences. 2015; 16(12):29673-29681. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms161226130

Chicago/Turabian Style

Szabó, László, Tünde Tóth, Erzsébet Takács, and László Wojnárovits. 2015. "One-Electron Reduction of Penicillins in Relation to the Oxidative Stress Phenomenon" International Journal of Molecular Sciences 16, no. 12: 29673-29681. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms161226130

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