Next Article in Journal
Dietary Compound Kaempferol Inhibits Airway Thickening Induced by Allergic Reaction in a Bovine Serum Albumin-Induced Model of Asthma
Next Article in Special Issue
Tissue Regeneration in the Chronically Inflamed Tumor Environment: Implications for Cell Fusion Driven Tumor Progression and Therapy Resistant Tumor Hybrid Cells
Previous Article in Journal
Transcriptome Characterization for Non-Model Endangered Lycaenids, Protantigius superans and Spindasis takanosis, Using Illumina HiSeq 2500 Sequencing
Previous Article in Special Issue
Connexin 50 Expression in Ependymal Stem Progenitor Cells after Spinal Cord Injury Activation
Communication

Stem Cell Replacement Improves Expression of SMP30 in db/db Mice

1
Department of Stem Cell Disorders, Kansai Medical University, Hirakata City, Osaka 5731010, Japan
2
Department of Cardiac Surgery, Beijing Anzhen Hospital affiliated to Capital Medical University, Beijing 100029, China
3
Department of Microbiology, Kansai Medical University, Hirakata City, Osaka 5731010, Japan
4
Division of Clinical Pathology, Toyooka Hospital, Hyogo 6688501, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Wilhelm Bloch
Int. J. Mol. Sci. 2015, 16(12), 29971-29979; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms161226217
Received: 28 October 2015 / Revised: 4 December 2015 / Accepted: 9 December 2015 / Published: 16 December 2015
(This article belongs to the Special Issue Stem Cell Activation in Adult Organism)
We have previously reported that replacing bone marrow stem cells may improve hyperglycemia and oxidative stress in db/db mice, a type 2 diabetic mouse model. Senescence marker protein 30 (SMP30) is an antioxidant protein that decreases with aging. However, it has not been clear whether SMP30 decreases in the livers of obese mice, and whether stem cell replacement would improve SMP30 expression in the liver. Bone marrow stem cells of db/db mice were replaced with the bone marrow stem cells of C57BL/6 mice. Plasma cytokine and insulin levels were measured, and glycogen content, expression of SMP30, and fibrosis in the liver were assessed. Our results showed that stem cell replacement increased the expression of SMP30 in the liver, resulting from decreased plasma inflammation cytokines and hyperinsulinemia in db/db mice. This is the first report that stem cell replacement increased the expression of SMP30 in the liver, and may help prevent fibrosis in the liver of db/db mice. View Full-Text
Keywords: SMP30; stem cell replacement; cytokines; fibrosis SMP30; stem cell replacement; cytokines; fibrosis
Show Figures

Figure 1

MDPI and ACS Style

Li, M.; Guo, K.; Taketani, S.; Adachi, Y.; Ikehara, S. Stem Cell Replacement Improves Expression of SMP30 in db/db Mice. Int. J. Mol. Sci. 2015, 16, 29971-29979. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms161226217

AMA Style

Li M, Guo K, Taketani S, Adachi Y, Ikehara S. Stem Cell Replacement Improves Expression of SMP30 in db/db Mice. International Journal of Molecular Sciences. 2015; 16(12):29971-29979. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms161226217

Chicago/Turabian Style

Li, Ming, Kequan Guo, Shigeru Taketani, Yasushi Adachi, and Susumu Ikehara. 2015. "Stem Cell Replacement Improves Expression of SMP30 in db/db Mice" International Journal of Molecular Sciences 16, no. 12: 29971-29979. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms161226217

Find Other Styles

Article Access Map by Country/Region

1
Back to TopTop