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Review

The Role of Galectin-3 in the Kidneys

by 1,2,3,4 and 1,5,*
1
Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
2
Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3
Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung 812, Taiwan
4
Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
5
Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Cheorl-Ho Kim
Int. J. Mol. Sci. 2016, 17(4), 565; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17040565
Received: 14 March 2016 / Revised: 8 April 2016 / Accepted: 11 April 2016 / Published: 14 April 2016
(This article belongs to the Special Issue Glycan–Receptor Interaction)
Galectin-3 is a 32- to 35-kDa member of the galectin family of b-galactoside-binding lectins, which is characterized by a carbohydrate recognition domain. Through its carbohydrate-binding function, it regulates cell growth, differentiation, and inflammation. It also plays a complex, context-dependent role in the kidneys. During development, it promotes nephrogenesis and is strongly expressed in the ureteric bud and its derivatives. An increase in the concentration of galectin-3 has been reported to be associated with fibrosis of the kidneys. Elevated levels of plasma galectin-3 are also associated with increased risks of rapid renal function decline, incident chronic kidney disease, and progressive renal impairment, and also with cardiovascular end points, infection, and all-cause mortality in patients with renal function impairment. This review discusses a general survey on galectin-3 expressions in nephrogenesis, kidney injury animal models, clinical renal diseases, renal transplantation and the potential role of galectin-3 for treatment in kidney disease. View Full-Text
Keywords: galectin-3; kidney; clinical renal disease; nephrogenesis galectin-3; kidney; clinical renal disease; nephrogenesis
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MDPI and ACS Style

Chen, S.-C.; Kuo, P.-L. The Role of Galectin-3 in the Kidneys. Int. J. Mol. Sci. 2016, 17, 565. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17040565

AMA Style

Chen S-C, Kuo P-L. The Role of Galectin-3 in the Kidneys. International Journal of Molecular Sciences. 2016; 17(4):565. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17040565

Chicago/Turabian Style

Chen, Szu-Chia, and Po-Lin Kuo. 2016. "The Role of Galectin-3 in the Kidneys" International Journal of Molecular Sciences 17, no. 4: 565. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17040565

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