Next Article in Journal
Inflammaging and Frailty Status Do Not Result in an Increased Extracellular Vesicle Concentration in Circulation
Next Article in Special Issue
The Effects of Aquaporin-1 in Pulmonary Edema Induced by Fat Embolism Syndrome
Previous Article in Journal
Immune Checkpoint Inhibitors: A New Opportunity in the Treatment of Ovarian Cancer?
Previous Article in Special Issue
Progress in AQP Research and New Developments in Therapeutic Approaches to Ischemic and Hemorrhagic Stroke
Review

Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation

Department of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Kenichi Ishibashi
Int. J. Mol. Sci. 2016, 17(7), 1172; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17071172
Received: 25 May 2016 / Revised: 12 July 2016 / Accepted: 14 July 2016 / Published: 20 July 2016
(This article belongs to the Special Issue Aquaporin)
Aquaporins (AQPs) play important roles in the water transport system in the human body. There are currently 13 types of AQP, AQP0 through AQP12, which are expressed in various organs. Many members of the AQP family are expressed in the intestinal tract. AQP3 is predominantly expressed in the colon, ultimately controlling the water transport. Recently, it was clarified that several laxatives exhibit a laxative effect by changing the AQP3 expression level in the colon. In addition, it was revealed that morphine causes severe constipation by increasing the AQP3 expression level in the colon. These findings have shown that AQP3 is one of the most important functional molecules in water transport in the colon. This review will focus on the physiological and pathological roles of AQP3 in the colon, and discuss clinical applications of colon AQP3. View Full-Text
Keywords: aquaporin; colon; diarrhea; laxative; constipation; morphine aquaporin; colon; diarrhea; laxative; constipation; morphine
Show Figures

Graphical abstract

MDPI and ACS Style

Ikarashi, N.; Kon, R.; Sugiyama, K. Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation. Int. J. Mol. Sci. 2016, 17, 1172. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17071172

AMA Style

Ikarashi N, Kon R, Sugiyama K. Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation. International Journal of Molecular Sciences. 2016; 17(7):1172. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17071172

Chicago/Turabian Style

Ikarashi, Nobutomo, Risako Kon, and Kiyoshi Sugiyama. 2016. "Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation" International Journal of Molecular Sciences 17, no. 7: 1172. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17071172

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop