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Review

Epigenetic Regulation of BDNF Gene during Development and Diseases

by 1 and 1,2,*
1
Institute of Molecular Medicine and Department of Medical Science, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan
2
Department of Medical Science, National Tsing Hua University, Hsinchu 30013, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Guiting Lin
Int. J. Mol. Sci. 2017, 18(3), 571; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18030571
Received: 24 January 2017 / Accepted: 1 March 2017 / Published: 6 March 2017
(This article belongs to the Special Issue Brain-Derived Neurotrophic Factor)
Brain-derived neurotrophic factor (BDNF) is required for the development of the nervous system, proper cognitive function and memory formation. While aberrant expression of BDNF has been implicated in neurological disorders, the transcriptional regulation of BDNF remains to be elucidated. In response to different stimuli, BDNF expression can be initiated from different promoters. Several studies have suggested that the expression of BDNF is regulated by promoter methylation. An emerging theme points to the possibility that histone modifications at the BDNF promoters may link to the neurological pathology. Thus, understanding the epigenetic regulation at the BDNF promoters will shed light on future therapies for neurological disorders. The present review summarizes the current knowledge of histone modifications of the BDNF gene in neuronal diseases, as well as the developmental regulation of the BDNF gene based on data from the Encyclopedia of DNA Elements (ENCODE). View Full-Text
Keywords: BDNF; histone modification; neuronal development; neurodegenerative disease BDNF; histone modification; neuronal development; neurodegenerative disease
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MDPI and ACS Style

Chen, K.-W.; Chen, L. Epigenetic Regulation of BDNF Gene during Development and Diseases. Int. J. Mol. Sci. 2017, 18, 571. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18030571

AMA Style

Chen K-W, Chen L. Epigenetic Regulation of BDNF Gene during Development and Diseases. International Journal of Molecular Sciences. 2017; 18(3):571. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18030571

Chicago/Turabian Style

Chen, Kuan-Wei, and Linyi Chen. 2017. "Epigenetic Regulation of BDNF Gene during Development and Diseases" International Journal of Molecular Sciences 18, no. 3: 571. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18030571

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