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Article

Intravenous Immunoglobulin Therapy Eliminates Candida albicans and Maintains Intestinal Homeostasis in a Murine Model of Dextran Sulfate Sodium-Induced Colitis

1
Inserm, U995/Team2, Université Lille, 1 place Verdun, F-59000 Lille, France
2
University Lille2, U995-LIRIC, Lille Inflammation Research International Centre, F-59000 Lille, France
3
CHU Lille, Service de Parasitologie Mycologie, Pôle de Biologie Pathologie Génétique, F-59000 Lille, France
4
Inserm Centre de Recherche des Cordeliers, Equipe-Immunopathologie et Immuno-intervention Thérapeutique, Sorbonne Universités, Université Paris Descartes, Sorbonne Paris Cité, F-75006 Paris, France
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(6), 1473; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20061473
Received: 13 February 2019 / Revised: 19 March 2019 / Accepted: 21 March 2019 / Published: 23 March 2019
Intravenous immunoglobulin (IVIg) therapy has diverse anti-inflammatory and immunomodulatory effects and has been employed successfully in autoimmune and inflammatory diseases. The role of IVIg therapy in the modulation of intestinal inflammation and fungal elimination has not been yet investigated. We studied IVIg therapy in a murine model of dextran sulfate sodium (DSS)-induced colitis. Mice received a single oral inoculum of Candida albicans and were exposed to DSS treatment for 2 weeks to induce colitis. All mice received daily IVIg therapy starting on day 1 for 7 days. IVIg therapy not only prevented a loss of body weight caused by the development of colitis but also reduced the severity of intestinal inflammation, as determined by clinical and histological scores. IVIg treatment significantly reduced the Escherichia coli, Enterococcus faecalis, and C. albicans populations in mice. The beneficial effects of IVIg were associated with the suppression of inflammatory cytokine interleukin (IL)-6 and enhancement of IL-10 in the gut. IVIg therapy also led to an increased expression of peroxisome proliferator-activated receptor gamma (PPARγ), while toll-like receptor 4 (TLR-4) expression was reduced. IVIg treatment reduces intestinal inflammation in mice and eliminates C. albicans overgrowth from the gut in association with down-regulation of pro-inflammatory mediators combined with up-regulation of anti-inflammatory cytokines. View Full-Text
Keywords: intravenous immunoglobulin G; colitis; dextran sulfate sodium; mice; inflammation; cytokines; Candida albicans; Escherichia coli; Enterococcus faecalis intravenous immunoglobulin G; colitis; dextran sulfate sodium; mice; inflammation; cytokines; Candida albicans; Escherichia coli; Enterococcus faecalis
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MDPI and ACS Style

Charlet, R.; Sendid, B.; Kaveri, S.V.; Poulain, D.; Bayry, J.; Jawhara, S. Intravenous Immunoglobulin Therapy Eliminates Candida albicans and Maintains Intestinal Homeostasis in a Murine Model of Dextran Sulfate Sodium-Induced Colitis. Int. J. Mol. Sci. 2019, 20, 1473. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20061473

AMA Style

Charlet R, Sendid B, Kaveri SV, Poulain D, Bayry J, Jawhara S. Intravenous Immunoglobulin Therapy Eliminates Candida albicans and Maintains Intestinal Homeostasis in a Murine Model of Dextran Sulfate Sodium-Induced Colitis. International Journal of Molecular Sciences. 2019; 20(6):1473. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20061473

Chicago/Turabian Style

Charlet, Rogatien, Boualem Sendid, Srini V. Kaveri, Daniel Poulain, Jagadeesh Bayry, and Samir Jawhara. 2019. "Intravenous Immunoglobulin Therapy Eliminates Candida albicans and Maintains Intestinal Homeostasis in a Murine Model of Dextran Sulfate Sodium-Induced Colitis" International Journal of Molecular Sciences 20, no. 6: 1473. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20061473

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