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Liquid Biopsy for the Diagnosis of Viral Hepatitis, Fatty Liver Steatosis, and Alcoholic Liver Diseases

by 1,2,†, 2,3,4,5,†, 3, 2,3,4,5,6, 4,5 and 1,2,3,*
1
Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
2
Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
3
Center for Liquid Biopsy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
4
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
5
Faculty of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
6
Hepatitis Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(10), 3732; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21103732
Received: 15 April 2020 / Revised: 18 May 2020 / Accepted: 19 May 2020 / Published: 25 May 2020
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
During the progression from hepatitis to fibrosis, cirrhosis, and liver failure, the accumulation of stressed/damaged hepatocyte elements associated with liver inflammation is critical. The causes of hepatocyte injuries include viral hepatitis infections, alcoholic hepatitis, and non-alcoholic fatty liver disease. Hepatocyte-derived extracellular vesicles (Hep-EVs) released from stressed/damaged hepatocytes are partly responsible for liver disease progression and liver damage because they activate non-parenchymal cells and infiltrate inflammatory cells within the liver, which are in turn are an important source of EVs. This cell-to-cell signaling is prevalent during inflammation in many liver diseases. Accordingly, special emphasis should be placed on liquid biopsy methods for the long-term monitoring of chronic liver diseases. In the present review, we have highlighted various aspects of current liquid biopsy research into chronic liver diseases. We have also reviewed recent progress on liquid biopsies that focus on cell-free DNA (cfDNA), long non-coding RNA (lncRNA), and the proteins in EVs as potential diagnostic tools and novel therapeutic targets in patients with viral hepatitis, fatty liver steatosis, and alcoholic liver diseases. View Full-Text
Keywords: viral hepatitis; non-alcoholic fatty liver disease; alcoholic liver disease; biomarkers; extracellular vesicles; microparticles; exosomes viral hepatitis; non-alcoholic fatty liver disease; alcoholic liver disease; biomarkers; extracellular vesicles; microparticles; exosomes
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MDPI and ACS Style

Shabangu, C.S.; Huang, J.-F.; Hsiao, H.-H.; Yu, M.-L.; Chuang, W.-L.; Wang, S.-C. Liquid Biopsy for the Diagnosis of Viral Hepatitis, Fatty Liver Steatosis, and Alcoholic Liver Diseases. Int. J. Mol. Sci. 2020, 21, 3732. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21103732

AMA Style

Shabangu CS, Huang J-F, Hsiao H-H, Yu M-L, Chuang W-L, Wang S-C. Liquid Biopsy for the Diagnosis of Viral Hepatitis, Fatty Liver Steatosis, and Alcoholic Liver Diseases. International Journal of Molecular Sciences. 2020; 21(10):3732. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21103732

Chicago/Turabian Style

Shabangu, Ciniso S., Jee-Fu Huang, Hui-Hua Hsiao, Ming-Lung Yu, Wan-Long Chuang, and Shu-Chi Wang. 2020. "Liquid Biopsy for the Diagnosis of Viral Hepatitis, Fatty Liver Steatosis, and Alcoholic Liver Diseases" International Journal of Molecular Sciences 21, no. 10: 3732. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21103732

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