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Review

Genetic Polymorphisms Associated with Rheumatoid Arthritis Development and Antirheumatic Therapy Response

1
Institute of Molecular Medicine, Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia
2
Laboratory of Epigenetics, Research Centre for Medical Genetics, 115478 Moscow, Russia
3
Department of Pharmacology and Pharmacy, Sechenov First Moscow State Medical University, 119991 Moscow, Russia
4
Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov First Moscow State Medical University, 119435 Moscow, Russia
5
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(14), 4911; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21144911
Received: 17 June 2020 / Revised: 8 July 2020 / Accepted: 9 July 2020 / Published: 11 July 2020
(This article belongs to the Special Issue Research of Pathogenesis and Novel Therapeutics in Arthritis 2.0)
Rheumatoid arthritis (RA) is the most common inflammatory arthropathy worldwide. Possible manifestations of RA can be represented by a wide variability of symptoms, clinical forms, and course options. This multifactorial disease is triggered by a genetic predisposition and environmental factors. Both clinical and genealogical studies have demonstrated disease case accumulation in families. Revealing the impact of candidate gene missense variants on the disease course elucidates understanding of RA molecular pathogenesis. A multivariate genomewide association study (GWAS) based analysis identified the genes and signalling pathways involved in the pathogenesis of the disease. However, these identified RA candidate gene variants only explain 30% of familial disease cases. The genetic causes for a significant proportion of familial RA have not been determined until now. Therefore, it is important to identify RA risk groups in different populations, as well as the possible prognostic value of some genetic variants for disease development, progression, and treatment. Our review has two purposes. First, to summarise the data on RA candidate genes and the increased disease risk associated with these alleles in various populations. Second, to describe how the genetic variants can be used in the selection of drugs for the treatment of RA. View Full-Text
Keywords: rheumatoid arthritis; polymorphism; genetic predisposition; mutation; methotrexate; interleukin; targeted therapy rheumatoid arthritis; polymorphism; genetic predisposition; mutation; methotrexate; interleukin; targeted therapy
MDPI and ACS Style

Mikhaylenko, D.S.; Nemtsova, M.V.; Bure, I.V.; Kuznetsova, E.B.; Alekseeva, E.A.; Tarasov, V.V.; Lukashev, A.N.; Beloukhova, M.I.; Deviatkin, A.A.; Zamyatnin, A.A., Jr. Genetic Polymorphisms Associated with Rheumatoid Arthritis Development and Antirheumatic Therapy Response. Int. J. Mol. Sci. 2020, 21, 4911. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21144911

AMA Style

Mikhaylenko DS, Nemtsova MV, Bure IV, Kuznetsova EB, Alekseeva EA, Tarasov VV, Lukashev AN, Beloukhova MI, Deviatkin AA, Zamyatnin AA Jr.. Genetic Polymorphisms Associated with Rheumatoid Arthritis Development and Antirheumatic Therapy Response. International Journal of Molecular Sciences. 2020; 21(14):4911. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21144911

Chicago/Turabian Style

Mikhaylenko, Dmitry S., Marina V. Nemtsova, Irina V. Bure, Ekaterina B. Kuznetsova, Ekaterina A. Alekseeva, Vadim V. Tarasov, Alexander N. Lukashev, Marina I. Beloukhova, Andrei A. Deviatkin, and Andrey A. Zamyatnin Jr. 2020. "Genetic Polymorphisms Associated with Rheumatoid Arthritis Development and Antirheumatic Therapy Response" International Journal of Molecular Sciences 21, no. 14: 4911. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21144911

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