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Article

Erythropoietin Mimetic Peptide (pHBSP) Corrects Endothelial Dysfunction in a Rat Model of Preeclampsia

1
Department of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia
2
Department of Obstetrics and Gynecology FPE, Kursk State Medical University, 305000 Kursk, Russia
3
Institute of Gene Biology of the Russian Academy of Sciences, Core Facility “Genome editing”, 119334 Moscow, Russia
4
Department of Histology, Embryology, Cytology, Kursk State Medical University, 305000 Kursk, Russia
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Department of Normal Physiology, Kursk State Medical University, 305000 Kursk, Russia
6
Department of Pharmacology, Kursk State Medical University, 305000 Kursk, Russia
7
Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305000 Kursk, Russia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(18), 6759; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186759
Received: 29 June 2020 / Revised: 11 September 2020 / Accepted: 11 September 2020 / Published: 15 September 2020
(This article belongs to the Special Issue Peptides for Health Benefits 2020)
Preeclampsia is a severe disease of late pregnancy. Etiological factors and a pathogenetic pattern of events still require significant clarification, but it is now recognized that a large role is played by placentation disorders and emerging endothelial dysfunction. The administration of short-chain peptides mimicking the spatial structure of the B erythropoietin chain may become one of the directions of searching for new drugs for preeclampsia prevention and therapy. Simulation of ADMA-like preeclampsia in Wistar rats was performed by the administration of a non-selective NOS blocker L-NAME from the 14th to 20th day of pregnancy. The administration of the pHBSP at the doses of 10 µg/kg and 250 µg/kg corrected the established morphofunctional disorders. The greatest effect was observed at a dose of 250 µg/kg. There was a decrease in systolic and diastolic blood pressure by 31.2 and 32.8%, respectively (p < 0.0001), a decrease in the coefficient of endothelial dysfunction by 48.6% (p = 0.0006), placental microcirculation increased by 82.8% (p < 0.0001), the NOx concentration was increased by 42,6% (p = 0.0003), the greater omentum edema decreased by 11.7% (p = 0.0005) and proteinuria decreased by 76.1% (p < 0.0002). In addition, there was an improvement in the morphological pattern of the fetoplacental complex and the ratio of BAX to Bcl-2 expression which characterizes the apoptotic orientation of the cells. View Full-Text
Keywords: endothelial dysfunction; preeclampsia; erythropoietin-derived peptide; pHBSP; placenta; Wistar rats endothelial dysfunction; preeclampsia; erythropoietin-derived peptide; pHBSP; placenta; Wistar rats
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MDPI and ACS Style

Korokin, M.; Gureev, V.; Gudyrev, O.; Golubev, I.; Korokina, L.; Peresypkina, A.; Pokrovskaia, T.; Lazareva, G.; Soldatov, V.; Zatolokina, M.; Pobeda, A.; Avdeeva, E.; Beskhmelnitsyna, E.; Denisyuk, T.; Avdeeva, N.; Bushueva, O.; Pokrovskii, M. Erythropoietin Mimetic Peptide (pHBSP) Corrects Endothelial Dysfunction in a Rat Model of Preeclampsia. Int. J. Mol. Sci. 2020, 21, 6759. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186759

AMA Style

Korokin M, Gureev V, Gudyrev O, Golubev I, Korokina L, Peresypkina A, Pokrovskaia T, Lazareva G, Soldatov V, Zatolokina M, Pobeda A, Avdeeva E, Beskhmelnitsyna E, Denisyuk T, Avdeeva N, Bushueva O, Pokrovskii M. Erythropoietin Mimetic Peptide (pHBSP) Corrects Endothelial Dysfunction in a Rat Model of Preeclampsia. International Journal of Molecular Sciences. 2020; 21(18):6759. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186759

Chicago/Turabian Style

Korokin, Mikhail, Vladimir Gureev, Oleg Gudyrev, Ivan Golubev, Liliya Korokina, Anna Peresypkina, Tatiana Pokrovskaia, Galina Lazareva, Vladislav Soldatov, Mariya Zatolokina, Anna Pobeda, Elena Avdeeva, Evgeniya Beskhmelnitsyna, Tatyana Denisyuk, Natalia Avdeeva, Olga Bushueva, and Mikhail Pokrovskii. 2020. "Erythropoietin Mimetic Peptide (pHBSP) Corrects Endothelial Dysfunction in a Rat Model of Preeclampsia" International Journal of Molecular Sciences 21, no. 18: 6759. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186759

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