Int. J. Mol. Sci., Volume 21, Issue 18 (September-2 2020) – 526 articles
Cover Story (view full-size image): The tumour microenvironment (TME) contains different cell types, including cancer, stromal, mesenchymal and endothelial cells, as well as cancer-associated fibroblasts and immune cells. In recent years, extracellular vesicles (EVs) released from all these cells have gained attention as cell-to-cell communication mediators in the TME. In the TME, EVs control different aspects of tumour growth and progression, including immune escape and pre-metastatic niche formation. However, EVs can also retain anti-tumour properties depending on the TME conditions and their cell of origin. Based on their functional properties, EVs have been proposed as tools for anti-cancer-based approaches. However, to exploit EVs as a novel therapeutic option, methods of boosting their anti-cancer properties while removing their tumour-promoting activity should be clearly defined. View this paper.
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