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International Journal of Molecular Sciences runs special issues to create collections of papers on specific topics. The aim is to build a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors who are experts in the subject and oversee the editorial process for papers. Papers published in a Special Issue will be collected together on a dedicated page of the journal website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pathogenesis and Treatment of Autism Spectrum Disorders 2.0
edited by
submission deadline 15 May 2022 | 4 articles | Viewed by 4690
Keywords: autism; arachidonic acid; signaling mediators; social impairment; drug targets
(This special issue belongs to the Section Molecular Neurobiology)
Ocular Disorders: From Age-Related to Genetically Determined Conditions submission deadline 15 May 2022 | 1 articles | Viewed by 938
Keywords: gene; macular degeneration; glaucoma; biomarkers; pathogenesis; chemical signaling; retina; cornea; molecular and cellular mechanisms; treatment options
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Extracellular Heat Shock Proteins as Regulator of the Immune System
edited by and
submission deadline 15 May 2022 | 1 articles | Viewed by 1412
Keywords: Circulating/extracellular heat shock protein (HSP); Chronic inflammation; Autoimmune diseases; Chronic inflammatory; lung diseases (asthma; COPD); Fibrosis; Rheumatism; Diabetes; Cardiovascular diseases; Neurology; Obesity
(This special issue belongs to the Section Molecular Immunology)
Telocytes and Other Interstitial Cells 2.0: From Structure to Function
edited by
submission deadline 15 May 2022 | 3 articles | Viewed by 3051
Keywords: interstitial cells; interstitial cells of Cajal; telocytes; intercellular communication; extracellular vesicles
(This special issue belongs to the Section Molecular Biology)
Non-Small-Cell Lung Cancer (NSCLC): The Changes of Molecular Immunotherapy and Targeted Therapy
edited by and Umberto Tirelli
submission deadline 15 May 2022 | 1 articles | Viewed by 610
Keywords: NSCLC; lung disease; target therapy; immunotherapy; cerebral metastasis
(This special issue belongs to the Section Molecular Oncology)
The Virome in Human Health and Diseases
edited by Patricia Agudelo-Romero, Anthony Kicic and Jose Caparros-Martin
submission deadline 15 May 2022 | Viewed by 242
Keywords: virome/viromics/virosphere; phageome; phage therapy; virus-bacteria interactions Interplay between viruses; bacteria and host Immune response to viruses; modulation of physiology by microbiota/viruses; metagenomics/metatranscriptomics
(This special issue belongs to the Section Molecular Microbiology)
Molecular Genetics and Breeding Mechanisms in Crops
edited by Shaozhen He
submission deadline 16 May 2022 | 4 articles | Viewed by 2513
Keywords: molecular breeding; molecular genetics; germplasm; genomics; transcriptomics; proteomics; biological stress; abiotic stress; molecular mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
Risk Factors and Molecular Mechanisms of Gestational Diabetes III
edited by
submission deadline 20 May 2022 | 2 articles | Viewed by 1478
Keywords: Gestational diabetes; Maternal obesity; Insulin resistance; Metabolism; Epigenetics; Lifestyle; interventions and therapeutics; Placenta; Newborn complications; Fetal programming
(This special issue belongs to the Section Molecular Genetics and Genomics)
From Omics to Therapeutic Targets in Cancer
edited by
submission deadline 20 May 2022 | 3 articles | Viewed by 2520
Keywords: multi-omics; bioinformatics; cancer; data integration; novel methods development; therapeutic targets or biomarkers; epigenetics; genetics; single cell omics
(This special issue belongs to the Section Molecular Genetics and Genomics)
RNA Structure and Function
edited by Michael T. Wolfinger
submission deadline 24 May 2022 | 3 articles | Viewed by 2627
Keywords: RNA structure RNA function RNA biology RNA structure prediction non-coding RNA co-trancriptional folding
(This special issue belongs to the Section Molecular Biophysics)
Prospective and Cutting-Edge Research for Diabetic Complications
edited by Daiji Kawanami
submission deadline 25 May 2022 | 2 articles | Viewed by 1926
Keywords: diabetic complications; diabetic retinopathy; diabetic kidney disease; diabetic macroangiopathy; bone metabolism in diabetes; hormones in diabetes; dementia; sarcopenia; frail; biomarkers; molecular biology
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Cytokine Release Syndrome: From Cell Metabolism to Organ Dysfunction
edited by
submission deadline 26 May 2022 | 1 articles | Viewed by 1597
Keywords: cytokine storm; cytokine release syndrome; CRS; immune-related adverse event; immunotherapy; COVID-19; SARS-CoV-2
(This special issue belongs to the Section Molecular Immunology)
Updates of Calcineurin/NFAT Signaling in Human Health and Diseases
edited by
submission deadline 26 May 2022 | 3 articles | Viewed by 3599
Keywords: allergy; bone metabolism; calcineurin; cancer; cell cycle; immunosuppressant; osmolarity; reproduction; NFAT
(This special issue belongs to the Section Molecular Immunology)
Skeletal Muscle Molecular Signalling in Various Models of Disuse and Unloading
edited by and Carlo Reggiani
submission deadline 27 May 2022 | 5 articles | Viewed by 3810
Keywords: skeletal muscle; disuse; unloading; inactivity; muscle atrophy; muscle atonia; slow-to-fast myosin transition; mitochondrial impairment; intracellular and intercellular signal transduction pathways; proteostasis; cytoskeleton; gene expression
(This special issue belongs to the Section Molecular Biophysics)
Emerging Therapies for Malignant Mesothelioma
edited by and Magkouta Sophia
submission deadline 27 May 2022 | 2 articles | Viewed by 1289
Keywords: pleural mesothelioma; immunotherapy; combination therapy; clinical trial; preclinical studies; pleural fluid; tumor microenvironment; adjuvant therapy; radiation therapy; cancer vaccines; nanotechnology; biomarkers
(This special issue belongs to the Section Molecular Oncology)
Plant Genetic Diversity and Genomics
edited by and
submission deadline 27 May 2022 | 3 articles | Viewed by 2210
Keywords: plant genetic diversity; speciation; phylogeography; evolutionary genetics; phylogenomics
(This special issue belongs to the Section Molecular Plant Sciences)
Amniotic Fluid and Placental Membranes as Sources of Stem Cells 2.0
edited by Tullia Maraldi and
submission deadline 27 May 2022 | 2 articles | Viewed by 1350
Keywords: amniotic fluid stem cells; amniotic epithelial stem cells; placental stem cells; regenerative therapy; immunomodulation; secretome; exosomes; degenerative diseases; inflammatory diseases
(This special issue belongs to the Section Molecular Immunology)
Molecular Research in Arabidopsis thaliana submission deadline 27 May 2022 | 6 articles | Viewed by 3763
Keywords: Arabidopsis growth and development; environmental adaptation; signaling processes; natural variation; hormone biology
(This special issue belongs to the Section Molecular Plant Sciences)
Nitric Oxide Signalling and Metabolism in Plants submission deadline 28 May 2022 | 3 articles | Viewed by 1706
Keywords: plant growth and development; postharvest; abiotic stress; fruit ripening; cut-flower; signal interactions; signal pathways; protein modification; gene regulation
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Kinase Drug Discovery 2.0 submission deadline 30 May 2022 | 1 articles | Viewed by 1275
Keywords: structure-guided drug discovery; kinase inhibitor; protein kinase; lipid kinase; nucleotide kinase; sugar kinase; fragment-based drug discovery; allosteric inhibitor; ATP-competitive inhibitor; anticancer; antibacterial; antiviral; anti-inflammatory
(This special issue belongs to the Section Macromolecules)
Nonalcoholic Fatty Liver Disease/Metabolic Associated Fatty Liver Disease: New Insights 2.0
edited by Alessandro Mantovani and
submission deadline 30 May 2022 | 3 articles | Viewed by 3379
Keywords: nonalcoholic fatty liver disease (NAFLD); metabolic associated fatty liver disease (MAFLD); nonalcoholic steatohepatitis (NASH); fatty liver; cardiovascular disease
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Understanding Traumatic Brain Injury: Mechanisms and Therapeutic Targets 3.0
edited by
submission deadline 30 May 2022 | 2 articles | Viewed by 3196
Keywords: Traumatic brain injury; TBI; Neurotrauma; Translational research; Axonal injury; Neuroimaing; Apoptosis; Head; Biomarker
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Targeted Cancer Therapy and Mechanisms of Resistance 2.0
edited by
submission deadline 30 May 2022 | 2 articles | Viewed by 2900
Keywords: cancer; kinase inhibitors; animal model; cell culture; drug resistance; signal transduction; survival; cell reprogramming; pathways; clinical trials; target therapy; cancer heterogeneity; stem cells; immunity; cell cycle; cell death inhibiting; survival; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Target and Action Mechanism of Anti-cancer Agents 2.0
edited by
submission deadline 30 May 2022 | 1 articles | Viewed by 909
Keywords: Cancer; Conventional therapy; Targeted therapy; Immunotherapy; Chemoprevention; Molecular target; Molecular mechanism; Drug resistance; Combinatorial therapy
(This special issue belongs to the Section Molecular Immunology)
Heavy Metals Accumulation, Toxicity and Detoxification in Plants 2.0
edited by and Alessio Aprile
submission deadline 30 May 2022 | 5 articles | Viewed by 3817
Keywords: Heavy metals; Plant physiological responses to heavy metals; Phytoremediation; Heavy metal accumulation in plants; Toxicity; Tolerance; Detoxification
(This special issue belongs to the Section Molecular Plant Sciences)
Adipokines in Health and Diseases 2.0
edited by
submission deadline 30 May 2022 | 2 articles | Viewed by 2342
Keywords: adiponectin; adipose tissue; adipokines; nutrition; molecular pathways; biomarkers; health; disease
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Neuroprotection: Rescue from Neuronal Death in the Brain 2.0
edited by
submission deadline 30 May 2022 | 10 articles | Viewed by 8363
Keywords: neuroprotection; brain injury; neuronal death; neurodegeneration; neurological disorders; functional plasticity; Neuroendocrinology; neuroendocrine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Intercellular and Intracellular Communication in Human Health and Disease 2.0
edited by
submission deadline 30 May 2022 | 3 articles | Viewed by 5029
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Chlamydia trachomatis Pathogenicity and Disease
edited by
submission deadline 30 May 2022 | 2 articles | Viewed by 1035
Keywords: Chlamydia trachomatis; virulence factors; host susceptibility or resistance; innate and adaptive; immune responses; genetic studies; cervico-vaginal microbiota; clinical outcomes with molecular study
(This special issue belongs to the Section Molecular Genetics and Genomics)
Nanoparticles for Tumor Imaging and Therapy
edited by
submission deadline 30 May 2022 | 3 articles | Viewed by 3217
Keywords: nanoparticle; nanomedicine; polymer; drug delivery; imaging; chemotherapy; tumor-targeting; self-assembly; tumor therapy; photodynamic therapy
(This special issue belongs to the Section Molecular Oncology)
The Role of Tissue-Nonspecific Alkaline Phosphatase in Inflammation and Metabolic Syndrome 2.0
edited by
submission deadline 30 May 2022 | 1 articles | Viewed by 1546
Keywords: tissue-nonspecific alkaline phosphatase (TNAP); inflammation; adenosine nucleotides; lipopolysaccharide; metabolic syndrome; vascular calcification; alkaline phosphatase; ALPL
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Impact of Engineered Nanomaterials on Cell Mechanics submission deadline 30 May 2022 | Viewed by 580
Keywords: engineered nanomaterials; cell mechanics; nano interaction; cell membranes; cytoskeletal alterations; toxicology
(This special issue belongs to the Section Molecular Biophysics)
Pathogenesis and Treatment of Cutaneous Lymphoma
edited by
submission deadline 30 May 2022 | 7 articles | Viewed by 5067
Keywords: cutaneous lymphoma; mycosis fungoides; Sé zary syndrome; chemokine; prognosis marker; tumor microenvironment; tumor immunity; Th2; autocrine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Morpho-Mechanical Approach to Characterize the Neurodegenerative Progression submission deadline 30 May 2022 | Viewed by 497
Keywords: neurodegenerative disorders (NDs); cell mechanics; amyloid aggregates; atomic force microscopy; cell membrane; confocal investigation; spectroscopic and electrochemistry
(This special issue belongs to the Section Molecular Biophysics)
Molecular Mechanisms of Osmotic Stress Tolerance in Plants
edited by
submission deadline 30 May 2022 | Viewed by 802
Keywords: dehydration; homeostasis; osmotic stress; signaling pathways; transcription factors
(This special issue belongs to the Section Molecular Plant Sciences)
Oxidative Stress and Skeletal Muscle Function
edited by
submission deadline 30 May 2022 | 1 articles | Viewed by 1449
Keywords: oxidative stress; exercise; physical activity; skeletal muscle; muscle damage; antioxidants; reactive oxygen species; redox balance; aging; nutrition
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Functional Nanomaterials and Polymer Nanocomposites: Current Uses and Potential Applications submission deadline 30 May 2022 | 11 articles | Viewed by 7143
Keywords: smart nanoparticles; synthesis and characterization; polymer nanocomposites; energy applications; biomedical applications; environmental applications
(This special issue belongs to the Section Materials Science)
Molecular Approaches for Understanding Dengue Disease submission deadline 30 May 2022 | 1 articles | Viewed by 1261
Keywords: dengue disease; severe dengue; viral pathogenesis; viral pathogenicity; mosquito vector– virus interaction; human host– virus interactions
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pleiotropic Effect of β-Adrenergic Receptors in Human Cancers and Other Human Diseases II
edited by Claudio Favre
submission deadline 31 May 2022 | Viewed by 152
Keywords: tumor microenvironment; β 3-adrenoreceptor; β 2-adrenoreceptor; metastasis; antioxidant activity; cancer
(This special issue belongs to the Section Molecular Oncology)
Bioactive Phytochemicals and Functional Food Ingredients in Fruits and Vegetables 2022 submission deadline 31 May 2022 | Viewed by 401
Keywords: dietary guideline; dietary fiber; essential nutrients; phytochemicals; functional food; degenerative pathologies
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular and Immunological Approaches in Ophthalmology: Inflammatory Disorders submission deadline 31 May 2022 | Viewed by 174
Keywords: diagnosis; uveitis; keratitis; ocular inflammation; hypersensitivity; cell surface molecules; antibodies; cytokines; autoimmunity; therapeutic
(This special issue belongs to the Section Biochemistry)
Purinergic P2 Receptors: Structure and Function 2.0
edited by
submission deadline 31 May 2022 | 7 articles | Viewed by 6367
Keywords: Extracellular ATP; Purinergic signaling; P2X receptor; P2Y receptor; ATP release; Molecular structure; Molecular pathway
(This special issue belongs to the Section Molecular Biology)
Melanin in Melanosomes: Changing Properties in Malignant Melanotic Degeneration of Skin Tissue
edited by
submission deadline 31 May 2022 | 1 articles | Viewed by 1325
(This special issue belongs to the Section Molecular Biology)
Bridging the Gap between the Clinical and Regulatory Use of Plasma Rich in Growth Factors. Where Are We? submission deadline 31 May 2022 | 2 articles | Viewed by 1790
Keywords: Advanced cell therapy; Platelet-rich plasma; Wound healing; Stem cells; Patient care; Medicine; Platelets; Plasma; Patient screening; Blood processing
(This special issue belongs to the Section Molecular Pharmacology)
Plasma Bioscience and Medicine Molecular Research
edited by and Eun Ha Choi
submission deadline 31 May 2022 | 5 articles | Viewed by 3284
Keywords: plasma medicine; nonthermal plasma; biomaterials; cell biology; cancer treatments; immuno-modulations; stem cells; nanomaterials; plasma agriculture; food processing; virus inactivation; antimicrobial activities
(This special issue belongs to the Section Molecular Biophysics)
Selenium and Selenoderivatives as Emerging Bioactive Agents for Human Diseases
edited by Carmen Sanmartín, Maria Javier Ramirez, and
submission deadline 31 May 2022 | Viewed by 218
Keywords: selenoderivatives; cancer; Alzheimer; Parkinson; parasitic diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Neuromelanin, Peripheral Melanin and Parkinson's Disease
edited by and Xiqun Chen
submission deadline 31 May 2022 | 1 articles | Viewed by 853
Keywords: neuromelanin; Parkinson’ s disease; substantia nigra; locus coeruleus; L-Dopamine; L-Norepinephrine; L-DOPA; melanoma
(This special issue belongs to the Section Biochemistry)
Cancer Immunotherapy: Tumor Microenvironment, Biomarker Discovery and Immune Resistance submission deadline 31 May 2022 | Viewed by 136
Keywords: cancer immunotherapy; tumor microenvironment; biomarkers; immune resistance; T cells; immune checkpoint; tumor-infiltrating lymphocytes; tumor mutational burden; dendritic cells; PD-L1
(This special issue belongs to the Section Molecular Oncology)
MicroRNA Signaling in Human Diseases 2.0
edited by
submission deadline 31 May 2022 | Viewed by 216
Keywords: microRNAs; inhibition of gene expression; miRNA targets; seed sequence; cell signaling; immune response; innate immune response; TLR signaling pathways; regulation of gene expression; miRNA mimics; miRNA antagonist
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Non-covalent Interaction
edited by and
submission deadline 31 May 2022 | 3 articles | Viewed by 1738
Keywords: noncovalent interactions; high-order electron correlation; density functional theory; halogen bond; machine learning techniques; molecular self-assembly; metal-organic complex; electronic excited state; surface adsorption
(This special issue belongs to the Section Materials Science)
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