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Application of microRNA in Human Osteoporosis and Fragility Fracture: A Systemic Review of Literatures

by 1,2,†, 1,2,3,4,5,6,†, 1,3,4,7, 1,2,3,4,5,6, 1,2,3,4,5,6, 1,2,4, 1,2,3,4,5,6, 1,2,4,6, 1,2,3,5, 8, 1,2,3,4,9, 1,2,3,4,9, 10,11, 12,* and 1,2,3,4,5,6,10,13,14,*
1
Orthopaedic Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan
2
Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80701, Taiwan
3
Regeneration Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan
4
Musculoskeletal Regeneration Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan
5
Department of Orthopedics, College of Medicine, Kaohsiung Medical University, Kaohsiung 80701, Taiwan
6
Department of Orthopedics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 80145, Taiwan
7
Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung 80701, Taiwan
8
Department of Veterinary Medicine, National Chiayi University, Chiayi 60004, Taiwan
9
Department of Orthopedics, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung 812, Taiwan
10
Department of Healthcare Administration and Medical Informatics, Kaohsiung Medical University, Kaohsiung 80701, Taiwan
11
Department of Medical Records, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80701, Taiwan
12
Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
13
Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80420, Taiwan
14
Graduate Institute of Animal Vaccine Technology, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 912301, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Alberto Falchetti
Int. J. Mol. Sci. 2021, 22(10), 5232; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105232
Received: 7 April 2021 / Revised: 10 May 2021 / Accepted: 11 May 2021 / Published: 15 May 2021
(This article belongs to the Special Issue Osteoporosis)
MicroRNAs (miRNAs) could serve as ideal entry points to the deregulated pathways in osteoporosis due to their relatively simple upstream and downstream relationships with other molecules in the signaling cascades. Our study aimed to give a comprehensive review of the already identified miRNAs in osteoporosis from human blood samples and provide useful information for their clinical application. A systematic literature search for relevant studies was conducted in the Pubmed database from inception to December 2020. We set two essential inclusion criteria: human blood sampling and design of controlled studies. We sorted the results of analysis on human blood samples according to the study settings and compiled the most promising miRNAs with analyzed diagnostic values. Furthermore, in vitro and in vivo evidence for the mechanisms of the identified miRNAs was also illustrated. Based on both diagnostic value and evidence of mechanism from in vitro and in vivo experiments, miR-23b-3p, miR-140-3p, miR-300, miR-155-5p, miR-208a-3p, and miR-637 were preferred candidates in diagnostic panels and as therapeutic agents. Further studies are needed to build sound foundations for the clinical usage of miRNAs in osteoporosis. View Full-Text
Keywords: blood sample; fragility fracture; microRNA; osteoporosis; osteoblast differentiation; osteoclast differentiation blood sample; fragility fracture; microRNA; osteoporosis; osteoblast differentiation; osteoclast differentiation
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MDPI and ACS Style

Wu, Y.-Z.; Huang, H.-T.; Cheng, T.-L.; Lu, Y.-M.; Lin, S.-Y.; Ho, C.-J.; Lee, T.-C.; Hsu, C.-H.; Huang, P.-J.; Huang, H.H.; Li, J.-Y.; Su, Y.-D.; Chen, S.-C.; Kang, L.; Chen, C.-H. Application of microRNA in Human Osteoporosis and Fragility Fracture: A Systemic Review of Literatures. Int. J. Mol. Sci. 2021, 22, 5232. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105232

AMA Style

Wu Y-Z, Huang H-T, Cheng T-L, Lu Y-M, Lin S-Y, Ho C-J, Lee T-C, Hsu C-H, Huang P-J, Huang HH, Li J-Y, Su Y-D, Chen S-C, Kang L, Chen C-H. Application of microRNA in Human Osteoporosis and Fragility Fracture: A Systemic Review of Literatures. International Journal of Molecular Sciences. 2021; 22(10):5232. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105232

Chicago/Turabian Style

Wu, Yen-Zung, Hsuan-Ti Huang, Tsung-Lin Cheng, Yen-Mou Lu, Sung-Yen Lin, Cheng-Jung Ho, Tien-Ching Lee, Chia-Hao Hsu, Peng-Ju Huang, Han H. Huang, Jhong-You Li, Yu-De Su, Shih-Chieh Chen, Lin Kang, and Chung-Hwan Chen. 2021. "Application of microRNA in Human Osteoporosis and Fragility Fracture: A Systemic Review of Literatures" International Journal of Molecular Sciences 22, no. 10: 5232. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105232

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